Vernonia amygdalina stimulates muscle glucose uptake and modulates redox activities and functional chemistry in oxidative hepatic injury.
Vernonia amygdalina
functional chemistry
glucose uptake
oxidative stress
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
30
03
2021
received:
18
12
2020
accepted:
07
05
2021
pubmed:
1
6
2021
medline:
21
4
2022
entrez:
31
5
2021
Statut:
ppublish
Résumé
The ethyl acetate, ethanol, and aqueous extracts sequentially obtained from the leaves of Vernonia amygdalina were investigated for their antidiabetic and antioxidant protective effect in oxidative hepatic injury. The extracts showed significant (p < .05) free radical scavenging and reducing power activities. They significantly (p < .05) elevated reduced glutathione level, superoxide dismutase, and catalase activities, with concomitant depletion of malondialdehyde level. The ethanol and aqueous extracts caused a removal of oxidative-included chemical functional group at 1,500-1,200 (amide II)/cm region, with the inclusion of a functional group at 3,000-2,800 (carboxylic acid)/cm region. The extracts significantly (p < .05) inhibited the activities of α-glucosidase and α-amylase and stimulated glucose uptake in rat muscles. Gas chromatography-mass spectrometric (GC-MS) analysis revealed phytol as the predominant compound, with ethanol having the highest concentration. Based on the IC
Substances chimiques
Antioxidants
0
Hypoglycemic Agents
0
Plant Extracts
0
Ethanol
3K9958V90M
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13794Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
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