Beta-Blocker Use Is Associated With Prevention of Left Ventricular Remodeling in Recovered Dilated Cardiomyopathy.
Adrenergic beta-Antagonists
/ adverse effects
Aged
Cardiomyopathy, Dilated
/ diagnostic imaging
Databases, Factual
Female
Heart Failure
/ diagnostic imaging
Humans
Japan
Male
Middle Aged
Stroke Volume
/ drug effects
Time Factors
Treatment Outcome
Ventricular Function, Left
/ drug effects
Ventricular Remodeling
/ drug effects
beta‐blocker
dilated cardiomyopathy
heart failure with recovered ejection fraction
remodeling
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
pubmed:
1
6
2021
medline:
3
11
2021
entrez:
31
5
2021
Statut:
ppublish
Résumé
Background Withdrawal of optimal medical therapy has been reported to relapse cardiac dysfunction in patients with dilated cardiomyopathy (DCM) whose cardiac function had improved. However, it is unknown whether beta-blockers can prevent deterioration of cardiac function in those patients. We examined the effect of beta-blockers on left ventricular ejection fraction (LVEF) in recovered DCM. Methods and Results We analyzed the clinical personal record of DCM, a national database of the Japanese Ministry of Health, Labor and Welfare, between 2003 and 2014. Recovered DCM was defined as a previously documented LVEF <40% and a current LVEF ≥40%. Patients with recovered DCM were divided into 2 groups according to the use of beta-blockers. A one-to-one propensity case-matched analysis was used. The primary outcome was defined as a decrease in LVEF >10% at 2 years of follow-up. Of 5370 eligible patients, 4104 received beta-blockers. Propensity score matching yielded 1087 pairs. Mean age was 61.9 years, and 1619 (74.5%) were men. Mean LVEF was 49.3±8.2%, and median B-type natriuretic peptide was 46.6 (interquartile range, 18.0-118.1) pg/mL. The primary outcome was observed less frequently in the beta-blocker group than in the no-beta-blocker group (19.6% versus 24.0%; odds ratio [OR], 0.77; 95% CI, 0.63-0.95;
Identifiants
pubmed: 34053244
doi: 10.1161/JAHA.120.019240
pmc: PMC8477863
doi:
Substances chimiques
Adrenergic beta-Antagonists
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e019240Subventions
Organisme : Arthritis Research UK
ID : FC001051
Pays : United Kingdom
Références
Lancet. 2019 Jan 5;393(10166):61-73
pubmed: 30429050
J Am Heart Assoc. 2021 Jun 15;10(12):e019240
pubmed: 34053244
Am Heart J. 2012 Jan;163(1):49-56.e2
pubmed: 22172436
J Am Heart Assoc. 2015 Jan 13;4(1):e001504
pubmed: 25587018
J Am Heart Assoc. 2019 Mar 19;8(6):e011077
pubmed: 30845873
JAMA Cardiol. 2016 Aug 1;1(5):510-8
pubmed: 27434402
J Am Coll Cardiol. 2010 Jul 27;56(5):392-406
pubmed: 20650361
Circulation. 2013 Oct 15;128(16):e240-327
pubmed: 23741058
Stat Methods Med Res. 2019 Jan;28(1):3-19
pubmed: 28573919
Eur J Heart Fail. 2018 Dec;20(12):1735-1743
pubmed: 30255969
Circulation. 1995 Sep 15;92(6):1499-506
pubmed: 7664433
J Am Coll Cardiol. 2002 Mar 20;39(6):946-53
pubmed: 11897434
J Am Coll Cardiol. 2013 Jan 8;61(1):54-63
pubmed: 23287372
Circ J. 2019 Sep 25;83(10):2084-2184
pubmed: 31511439
Br Heart J. 1980 Aug;44(2):134-42
pubmed: 6107091
Can J Cardiol. 2009 May;25(5):e147-50
pubmed: 19417864
Eur Heart J. 2019 Jul 1;40(26):2110-2117
pubmed: 31280320
Circ Cardiovasc Imaging. 2013 Sep;6(5):790-9
pubmed: 23934992
Circ Heart Fail. 2014 May;7(3):434-9
pubmed: 24563449
J Am Coll Cardiol. 2002 Jul 17;40(2):304-10
pubmed: 12106936
Heart. 2011 May;97(9):727-32
pubmed: 21097819
J Card Fail. 2011 Jul;17(7):527-32
pubmed: 21703523
J Am Coll Cardiol. 2012 Dec 18;60(24):2465-72
pubmed: 23158527
J Am Coll Cardiol. 1997 Apr;29(5):1060-6
pubmed: 9120160
Eur J Heart Fail. 2002 Dec;4(6):765-70
pubmed: 12453548
Circulation. 2006 Jan 17;113(2):266-72
pubmed: 16401777
Circulation. 2014 Jun 10;129(23):2380-7
pubmed: 24799515
Circ Heart Fail. 2016 Jul;9(7):
pubmed: 27413037
J Am Coll Cardiol. 1994 Mar 1;23(3):553-9
pubmed: 8113533
Circulation. 2002 Jan 29;105(4):438-45
pubmed: 11815425
Sci Rep. 2018 Jan 31;8(1):1998
pubmed: 29386531
J Am Coll Cardiol. 2011 Mar 29;57(13):1468-76
pubmed: 21435516