Local radiotherapy for pleural dissemination of thymic tumors after initial treatment.
intensity modulated radiation therapy
local radiation therapy
pleural dissemination
thymic tumors
Journal
Journal of radiation research
ISSN: 1349-9157
Titre abrégé: J Radiat Res
Pays: England
ID NLM: 0376611
Informations de publication
Date de publication:
10 Jul 2021
10 Jul 2021
Historique:
received:
11
01
2021
revised:
13
03
2021
accepted:
28
04
2021
pubmed:
27
5
2021
medline:
24
12
2021
entrez:
26
5
2021
Statut:
ppublish
Résumé
Pleural dissemination is a common pattern of failure after initial treatment of thymoma and thymic carcinoma, but there is no standardized treatment. As these tumors are relatively radiosensitive, we investigated the effectiveness of radiotherapy. Twenty patients underwent 33 series of local radiotherapy for 96 pleural dissemination lesions after initial treatment. Conventional radiotherapy (CRT), tomotherapy, and combination of the two were employed in 19, 13, and 1 series, respectively. The median follow-up period after the first irradiation for pleural dissemination was 46 months (range, 14-161). For all 20 patients, overall survival (OS) rates from initial radiotherapy for pleural dissemination were 100% at three years and 86% at five years. Progression-free survival (PFS) rates after 33 series of radiotherapy were 30% at three years and 16% at five years. Local control (LC) rates for 96 lesions were 98% at three years and 96% at five years. In-field recurrence was observed in only two among the 96 lesions. One patient (5%) developed grade 3 radiation pneumonitis and another (5%) developed grade 3 pericardial effusion. No other serious adverse events were observed. When disseminated nodules can be covered within localized fields, local radiotherapy may be a treatment option. Using tomotherapy, multiple lesions can be treated safely.
Identifiants
pubmed: 34036359
pii: 6283624
doi: 10.1093/jrr/rrab046
pmc: PMC8273798
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
676-681Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.
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