Non-alcoholic fatty liver disease and lipotoxicity.
lipotoxicity
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
Journal
Clinical and experimental hepatology
ISSN: 2392-1099
Titre abrégé: Clin Exp Hepatol
Pays: Poland
ID NLM: 101703431
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
07
12
2020
accepted:
08
01
2021
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
ppublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) has become the most common liver pathology worldwide due to the rising prevalence of obesity. This term includes changes from simple steatosis to steatohepatitis and fibrosis. It was previously thought to be a hepatic manifestation of metabolic syndrome, but recent literature describes this relation as much more complex and bi-directional. Development of NAFLD is associated with other metabolic syndrome components but it can also exacerbate insulin resistance and increase cardiovascular risk. Recently a lot of attention is brought to the role of lipids and lipotoxicity in pathogenesis and progression of non-alcoholic fatty disease. It seems that some lipid classes can be protective against liver injury while others are harmful in excessive amounts. This study presents an overview of the main lipids involved in the pathogenesis of non-alcoholic fatty liver disease and summarizes their association with lipotoxicity, insulin resistance, oxidative stress and other processes responsible for its progression.
Identifiants
pubmed: 34027109
doi: 10.5114/ceh.2021.104441
pii: 43509
pmc: PMC8122097
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1-6Informations de copyright
Copyright © 2021 Clinical and Experimental Hepatology.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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