A Quinol Anion as Catalytic Intermediate Coupling Proton Translocation With Electron Transfer in
Escherichia coli
NADH dehydrogenase
bioenergetics
proton-coupled electron transfer
quinone chemistry
respiratory complex I
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
03
2021
accepted:
09
04
2021
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
epublish
Résumé
Energy-converting NADH:ubiquinone oxidoreductase, respiratory complex I, plays a major role in cellular energy metabolism. It couples NADH oxidation and quinone reduction with the translocation of protons across the membrane, thus contributing to the protonmotive force. Complex I has an overall L-shaped structure with a peripheral arm catalyzing electron transfer and a membrane arm engaged in proton translocation. Although both reactions are arranged spatially separated, they are tightly coupled by a mechanism that is not fully understood. Using redox-difference UV-vis spectroscopy, an unknown redox component was identified in
Identifiants
pubmed: 34026733
doi: 10.3389/fchem.2021.672969
pmc: PMC8138167
doi:
Types de publication
Journal Article
Langues
eng
Pagination
672969Informations de copyright
Copyright © 2021 Nuber, Mérono, Oppermann, Schimpf, Wohlwend and Friedrich.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Biochemistry. 1998 Feb 17;37(7):1861-7
pubmed: 9485311
Science. 2020 Oct 30;370(6516):
pubmed: 32972993
Biochemistry. 1999 Nov 2;38(44):14683-9
pubmed: 10545194
Biochemistry. 2013 Dec 17;52(50):8993-9000
pubmed: 24279322
Biochim Biophys Acta. 1998 Jun 10;1365(1-2):215-9
pubmed: 9693737
Biochim Biophys Acta. 1986 Jul 23;850(3):413-22
pubmed: 3015206
Front Chem. 2019 Apr 09;7:221
pubmed: 31024903
Nature. 1961 Jul 8;191:144-8
pubmed: 13771349
Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2844-8
pubmed: 25600069
J Am Chem Soc. 2020 Aug 12;142(32):13718-13728
pubmed: 32643371
Nat Struct Mol Biol. 2020 Oct;27(10):892-900
pubmed: 32747785
J R Soc Interface. 2018 Apr;15(141):
pubmed: 29643224
Eur J Biochem. 1989 Mar 1;180(1):173-80
pubmed: 2523306
Biochim Biophys Acta. 2000 Aug 15;1459(2-3):305-9
pubmed: 11004444
Annu Rev Biophys. 2019 May 6;48:165-184
pubmed: 30786232
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8413-E8420
pubmed: 30120126
Biol Chem. 2018 Oct 25;399(11):1249-1264
pubmed: 30243012
Nat Commun. 2018 Oct 29;9(1):4500
pubmed: 30374105
Biochim Biophys Acta. 2014 Feb;1837(2):246-50
pubmed: 24216024
Biofactors. 1998;8(3-4):177-86
pubmed: 9914816
Bioorg Chem. 2014 Dec;57:213-221
pubmed: 25085775
Biochim Biophys Acta. 1980 Jun 10;591(1):153-61
pubmed: 7388012
J Am Chem Soc. 2017 Nov 15;139(45):16282-16288
pubmed: 29017321
Nat Commun. 2020 Aug 18;11(1):4135
pubmed: 32811817
Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11571-6
pubmed: 26330610
Nature. 2013 Feb 28;494(7438):443-8
pubmed: 23417064
Annu Rev Biochem. 2013;82:551-75
pubmed: 23527692
Biochim Biophys Acta. 2011 Oct;1807(10):1364-9
pubmed: 21565159
Biochim Biophys Acta. 2016 Aug;1857(8):1068-1072
pubmed: 26944855
Chem Rev. 2015 Mar 11;115(5):2196-221
pubmed: 25694135
Nat Commun. 2020 Oct 16;11(1):5261
pubmed: 33067417
Mol Microbiol. 2019 Jan;111(1):31-45
pubmed: 30251413
Sci Adv. 2019 Dec 11;5(12):eaax9484
pubmed: 31844670
Nat Rev Mol Cell Biol. 2015 Jun;16(6):375-88
pubmed: 25991374
Sci Rep. 2017 Aug 10;7(1):7747
pubmed: 28798393
Biochim Biophys Acta. 2010 Dec;1797(12):1883-90
pubmed: 20493164
Biochemistry. 2001 May 22;40(20):6124-31
pubmed: 11352750
Anal Biochem. 1987 Nov 1;166(2):368-79
pubmed: 2449095
Biochim Biophys Acta. 2012 Sep;1817(9):1550-6
pubmed: 22580197