COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study.
clinical research/practice
infection and infectious agents - viral
infectious disease
lung (allograft) function/dysfunction
lung disease: infectious
lung transplantation/pulmonology
organ transplantation in general
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
23
04
2021
received:
28
03
2021
accepted:
06
05
2021
pubmed:
20
5
2021
medline:
11
8
2021
entrez:
19
5
2021
Statut:
ppublish
Résumé
Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p = .02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p = .032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0-2.6, p = .04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0-11.3, p = .05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.
Identifiants
pubmed: 34008917
doi: 10.1111/ajt.16692
pmc: PMC9215359
mid: NIHMS1759171
pii: S1600-6135(22)08676-2
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2774-2784Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL143050
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI118690
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : T32AI118690
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.
Références
Transplantation. 2021 Jan 1;105(1):138-150
pubmed: 32941394
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
JAMA Netw Open. 2021 Mar 1;4(3):e210417
pubmed: 33666657
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
Am J Transplant. 2021 May;21(5):1825-1837
pubmed: 33098200
Am J Transplant. 2020 Nov;20(11):3234-3238
pubmed: 32659857
Kidney Int. 2020 Dec;98(6):1549-1558
pubmed: 32853631
Am J Transplant. 2020 Jul;20(7):1800-1808
pubmed: 32330343
Transplantation. 2021 Jan 1;105(1):177-186
pubmed: 33141808
J Thorac Dis. 2019 Sep;11(Suppl 14):S1721-S1731
pubmed: 31632749
J Biomed Inform. 2009 Apr;42(2):377-81
pubmed: 18929686
Lancet Gastroenterol Hepatol. 2020 Nov;5(11):1008-1016
pubmed: 32866433
Clin Infect Dis. 2021 Dec 6;73(11):e4090-e4099
pubmed: 32766815
Clin Transplant. 2021 Apr;35(4):e14216
pubmed: 33406279
Am J Transplant. 2020 Nov;20(11):3072-3080
pubmed: 32881315
BMJ. 2020 May 22;369:m1966
pubmed: 32444366
J Biomed Inform. 2019 Jul;95:103208
pubmed: 31078660
J Clin Anesth. 2011 Sep;23(6):508-16
pubmed: 21911200
Am J Transplant. 2021 Jul;21(7):2522-2531
pubmed: 33443778
Transpl Infect Dis. 2021 Feb;23(1):e13421
pubmed: 32779808
J Med Virol. 2021 Apr;93(4):1843-1846
pubmed: 33314219