Spatial extent of a single lipid's influence on bilayer mechanics.
Journal
Physical review. E
ISSN: 2470-0053
Titre abrégé: Phys Rev E
Pays: United States
ID NLM: 101676019
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
12
12
2020
accepted:
25
03
2021
entrez:
19
5
2021
pubmed:
20
5
2021
medline:
20
5
2021
Statut:
ppublish
Résumé
To what spatial extent does a single lipid affect the mechanical properties of the membrane that surrounds it? The lipid composition of a membrane determines its mechanical properties. The shapes available to the membrane depend on its compositional material properties, and therefore, the lipid environment. Because each individual lipid species' chemistry is different, it is important to know its range of influence on membrane mechanical properties. This is defined herein as the lipid's mechanical extent. Here, a lipid's mechanical extent is determined by quantifying lipid redistribution and the average curvature that lipid species experience on fluctuating membrane surfaces. A surprising finding is that, unlike unsaturated lipids, saturated lipids have a complicated, nonlocal effect on the surrounding surface, with the interaction strength maximal at a finite length-scale. The methodology provides the means to substantially enrich curvature-energy models of membrane structures, quantifying what was previously only conjecture.
Identifiants
pubmed: 34005918
doi: 10.1103/PhysRevE.103.042413
pmc: PMC8941725
mid: NIHMS1786199
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
042413Subventions
Organisme : Intramural NIH HHS
ID : ZIA HD008955
Pays : United States
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