Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India.
Adolescent
Adult
Antimalarials
/ pharmacology
Artemisinins
/ metabolism
Drug Resistance
/ genetics
Drug Therapy, Combination
/ methods
Female
Humans
India
/ epidemiology
Kelch Repeat
/ genetics
Malaria
/ drug therapy
Malaria, Falciparum
/ drug therapy
Male
Middle Aged
Mutation
/ drug effects
Phenotype
Plasmodium falciparum
/ drug effects
Polymorphism, Genetic
/ genetics
Protozoan Proteins
/ genetics
Pyrimethamine
/ therapeutic use
Sulfadoxine
/ therapeutic use
Tetrahydrofolate Dehydrogenase
/ genetics
Treatment Outcome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
received:
30
01
2021
accepted:
23
04
2021
entrez:
12
5
2021
pubmed:
13
5
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Artemisinin is the frontline fast-acting anti-malarial against P. falciparum. Emergence and spread of resistant parasite in eastern-India poses a threat to national malaria control programs. Therefore, the objective of our study is to evaluate the artesunate-sulfadoxine-pyrimethamine efficacy in Central India. 180 monoclonal P. falciparum-infected patients received standard ASSP therapy during August 2015-January 2017, soon after diagnosis and monitored over next 42-days. Artemisinin-resistance was assessed through in-vivo parasite clearance half-life (PC
Identifiants
pubmed: 33976269
doi: 10.1038/s41598-021-89295-0
pii: 10.1038/s41598-021-89295-0
pmc: PMC8113598
doi:
Substances chimiques
Antimalarials
0
Artemisinins
0
Protozoan Proteins
0
Sulfadoxine
88463U4SM5
artemisinin
9RMU91N5K2
Tetrahydrofolate Dehydrogenase
EC 1.5.1.3
Pyrimethamine
Z3614QOX8W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9946Références
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