Isoflavanquinones from Abrus precatorius roots with their antiproliferative and anti-inflammatory effects.

Abrus Fabaceae
Abruquinone Abrus precatorius Anti-inflammatory Anti-proliferative Fabaceae Isoflavanquinone Isoflavanquinones

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Jul 2021
Historique:
received: 06 11 2020
revised: 11 03 2021
accepted: 12 03 2021
pubmed: 8 5 2021
medline: 26 5 2021
entrez: 7 5 2021
Statut: ppublish

Résumé

Phytochemical studies on the root of Abrus precatorius Linn. (Fabaceae), leads towards the identification of four undescribed (abruquinones M, N, O, and P), and seven known abruquinones, (abruquinones A, E, B, F, I, D, and G). Spectroscopic analyses (1D, and 2D NMR, HRESI-MS) were used in elucidating structures of the all compounds. Evaluation of anticancer activities of the isolated isoflavanquinones revealed that abruquinones M, and N showed cytotoxicity against oral CAL-27 (IC

Identifiants

DOI: 10.1016/j.phytochem.2021.112743 PMID: 33962136
pubmed: 33962136
pii: S0031-9422(21)00090-X
doi: 10.1016/j.phytochem.2021.112743
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112743

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Emeka E Okoro (EE)

Biochemistry Department, Babcock University Ilishan-Remo, Ikeja, PMB 21244, Nigeria; Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan; Biology Department, Adventist University of West Africa, Monrovia, Liberia. Electronic address: okoroemeka2003@gmail.com.

Rukesh Maharjan (R)

HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.

Almas Jabeen (A)

Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Malik Shoaib Ahmad (MS)

Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.

Mudassir Azhar (M)

Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Nuzhat Shehla (N)

HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.

Wajid Zaman (W)

Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Sidrah Shams (S)

Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Omolaja R Osoniyi (OR)

Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile Ife, Nigeria.

Funmilayo D Onajobi (FD)

Biochemistry Department, Babcock University Ilishan-Remo, Ikeja, PMB 21244, Nigeria.

M Iqbal Choudhary (MI)

Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Abrus › Isoflavanquinones from Abrus precatorius roots...
Recherchemedicale.com › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Isoflavanquinones from Abrus precatorius roots...