Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study.
Adult
Animals
Blood Glucose
/ drug effects
Chrysanthemum
/ chemistry
Cynara scolymus
/ chemistry
Glycemic Control
/ methods
Homeostasis
/ drug effects
Humans
Hyperglycemia
/ blood
Male
Mice
Mice, Inbred C57BL
Middle Aged
Olea
/ chemistry
Overweight
/ blood
Pilot Projects
Piper nigrum
/ chemistry
Plant Extracts
/ chemistry
Postprandial Period
/ drug effects
Translational Research, Biomedical
Vaccinium myrtillus
/ chemistry
diabetes
glucose
prevention
translational
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
pubmed:
4
5
2021
medline:
31
7
2021
entrez:
3
5
2021
Statut:
ppublish
Résumé
Global prevalence of type 2 diabetes (T2D) is rising and may affect 700 million people by 2045. Totum-63 is a polyphenol-rich natural composition developed to reduce the risk of T2D. We first investigated the effects of Totum-63 supplementation in high-fat diet (HFD)-fed mice for up to 16 wk and thereafter assessed its safety and efficacy (2.5 g or 5 g per day) in 14 overweight men [mean age 51.5 yr, body mass index (BMI) 27.6 kg·m
Identifiants
pubmed: 33938234
doi: 10.1152/ajpendo.00629.2020
pmc: PMC8285600
doi:
Substances chimiques
Blood Glucose
0
Plant Extracts
0
olive leaf extract
MJ95C3OH47
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
E1119-E1137Subventions
Organisme : NIDDK NIH HHS
ID : U24 DK076169
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK115255
Pays : United States
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