A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes.

2-Aminopurine / analogs & derivatives Adenylosuccinate Synthase / chemistry Bacteriophages / chemistry Biosynthetic Pathways Crystallography, X-Ray DNA, Viral / chemistry Genome, Viral Phylogeny Viral Nonstructural Proteins / chemistry

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
30 04 2021
Historique:
received: 04 09 2020
accepted: 25 03 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 14 5 2021
Statut: ppublish

Résumé

Cells have two purine pathways that synthesize adenine and guanine ribonucleotides from phosphoribose via inosylate. A chemical hybrid between adenine and guanine, 2-aminoadenine (Z), replaces adenine in the DNA of the cyanobacterial virus S-2L. We show that S-2L and

Identifiants

DOI: 10.1126/science.abe6494 PMID: 33926955
pubmed: 33926955
pii: 372/6541/516
doi: 10.1126/science.abe6494
doi:

Substances chimiques

DNA, Viral 0
Viral Nonstructural Proteins 0
2-Aminopurine 452-06-2
2,6-diaminopurine 49P95BAU4Z
Adenylosuccinate Synthase EC 6.3.4.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

516-520

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Dona Sleiman (D)

Biology of Gram-Positive Pathogens, Institut Pasteur, CNRS-UMR 2001, Paris, France.
ORCID: 0000-0002-4005-6514

Pierre Simon Garcia (PS)

Evolutionary Biology of the Microbial Cell, Institut Pasteur, CNRS-UMR 2001, Paris, France.
Stress Adaptation and Metabolism, Institut Pasteur, CNRS-UMR 2001, Paris, France.
ORCID: 0000-0001-7444-899X

Marion Lagune (M)

Biology of Gram-Positive Pathogens, Institut Pasteur, CNRS-UMR 2001, Paris, France.
ORCID: 0000-0001-9600-5719

Jerome Loc'h (J)

Structural Dynamics of Macromolecules, Institut Pasteur, CNRS-UMR 3528, Paris, France.
ORCID: 0000-0001-9495-3926

Ahmed Haouz (A)

Crystallography Platform, C2RT, Institut Pasteur, CNRS-UMR 3528, Paris, France.
ORCID: 0000-0003-1196-1635

Najwa Taib (N)

Evolutionary Biology of the Microbial Cell, Institut Pasteur, CNRS-UMR 2001, Paris, France.
Hub Bioinformatics and Biostatistics, Institut Pasteur, Paris, France.
ORCID: 0000-0002-1422-043X

Pascal Röthlisberger (P)

Bioorganic Chemistry of Nucleic Acids, Institut Pasteur, CNRS-UMR 3523, Paris, France.

Simonetta Gribaldo (S)

Evolutionary Biology of the Microbial Cell, Institut Pasteur, CNRS-UMR 2001, Paris, France.
ORCID: 0000-0002-7662-021X

Philippe Marlière (P)

Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Université Evry, Université Paris-Saclay, Evry, France.
ORCID: 0000-0002-7869-5071

Pierre Alexandre Kaminski (PA)

Biology of Gram-Positive Pathogens, Institut Pasteur, CNRS-UMR 2001, Paris, France. pierre-alexandre.kaminski@pasteur.fr.
ORCID: 0000-0001-9841-6837

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Classifications MeSH

Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Adénine › Amino-2 purine › A third purine biosynthetic pathway encoded by...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Ligases › Carbon-nitrogen ligases › Adenylosuccinate synthase › A third purine biosynthetic pathway encoded by...
Recherchemedicale.com › Virus › Bactériophages › A third purine biosynthetic pathway encoded by...
Recherchemedicale.com › Métabolisme › Voies et réseaux métaboliques › Voies de biosynthèse › A third purine biosynthetic pathway encoded by...
Recherchemedicale.com › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › A third purine biosynthetic pathway encoded by...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN viral › A third purine biosynthetic pathway encoded by...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome viral › A third purine biosynthetic pathway encoded by...
Recherchemedicale.com › Sciences de l'information › Phylogenèse › A third purine biosynthetic pathway encoded by...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales non structurales › A third purine biosynthetic pathway encoded by...