Distinction of Physiologic and Epileptic Ripples: An Electrical Stimulation Study.
electroencephalography
epilepsy
high-frequency oscillations
intracranial
neocortical
physiologic
stimulation
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
24 Apr 2021
24 Apr 2021
Historique:
received:
15
03
2021
revised:
15
04
2021
accepted:
19
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Ripple oscillations (80-250 Hz) are a promising biomarker of epileptic activity, but are also involved in memory consolidation, which impairs their value as a diagnostic tool. Distinguishing physiologic from epileptic ripples has been particularly challenging because usually, invasive recordings are only performed in patients with refractory epilepsy. Here, we identified 'healthy' brain areas based on electrical stimulation and hypothesized that these regions specifically generate 'pure' ripples not coupled to spikes. Intracranial electroencephalography (EEG) recorded with subdural grid electrodes was retrospectively analyzed in 19 patients with drug-resistant focal epilepsy. Interictal spikes and ripples were automatically detected in slow-wave sleep using the publicly available Delphos software. We found that rates of spikes, ripples and ripples coupled to spikes ('spike-ripples') were higher inside the seizure-onset zone (
Identifiants
pubmed: 33923317
pii: brainsci11050538
doi: 10.3390/brainsci11050538
pmc: PMC8146715
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Faculty of Medicine, University of Freiburg
ID : Berta-Ottenstein-Program for Clinician Scientists
Organisme : Deutsche Forschungsgemeinschaft
ID : JA 1725/4-1
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