Arthropod Ectoparasites Have Potential to Bind SARS-CoV-2 via ACE.
Angiotensin-Converting Enzyme 2
/ chemistry
Animals
Arthropod Proteins
/ chemistry
Arthropods
/ chemistry
Binding Sites
COVID-19
/ transmission
Ectoparasitic Infestations
/ parasitology
Humans
Models, Molecular
Mutation
Peptidyl-Dipeptidase A
/ chemistry
Phylogeny
Protein Binding
SARS-CoV-2
/ chemistry
Sequence Homology
Spike Glycoprotein, Coronavirus
/ chemistry
ACE2
COVID-19
SARS-CoV-2
parasite
spike protein
structural bioinformatics
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
19 04 2021
19 04 2021
Historique:
received:
02
04
2021
revised:
16
04
2021
accepted:
16
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
7
5
2021
Statut:
epublish
Résumé
Coronavirus-like organisms have been previously identified in Arthropod ectoparasites (such as ticks and unfed cat flea). Yet, the question regarding the possible role of these arthropods as SARS-CoV-2 passive/biological transmission vectors is still poorly explored. In this study, we performed in silico structural and binding energy calculations to assess the risks associated with possible ectoparasite transmission. We found sufficient similarity between ectoparasite ACE and human ACE2 protein sequences to build good quality 3D-models of the SARS-CoV-2 Spike:ACE complex to assess the impacts of ectoparasite mutations on complex stability. For several species (e.g., water flea, deer tick, body louse), our analyses showed no significant destabilisation of the SARS-CoV-2 Spike:ACE complex, suggesting these species would bind the viral Spike protein. Our structural analyses also provide structural rationale for interactions between the viral Spike and the ectoparasite ACE proteins. Although we do not have experimental evidence of infection in these ectoparasites, the predicted stability of the complex suggests this is possible, raising concerns of a possible role in passive transmission of the virus to their human hosts.
Identifiants
pubmed: 33921873
pii: v13040708
doi: 10.3390/v13040708
pmc: PMC8073597
pii:
doi:
Substances chimiques
Arthropod Proteins
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Peptidyl-Dipeptidase A
EC 3.4.15.1
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
J Med Entomol. 2005 Jul;42(4):668-75
pubmed: 16119558
Curr Protoc Bioinformatics. 2016 Jun 20;54:5.6.1-5.6.37
pubmed: 27322406
Euro Surveill. 2017 Mar 30;22(13):
pubmed: 28382917
mBio. 2020 Oct 13;11(5):
pubmed: 33051368
Commun Biol. 2020 Oct 27;3(1):641
pubmed: 33110195
Biomolecules. 2020 Apr 05;10(4):
pubmed: 32260542
PLoS Pathog. 2016 Apr 21;12(4):e1005488
pubmed: 27099928
Signal Transduct Target Ther. 2020 Oct 19;5(1):157
pubmed: 32814760
Science. 2020 Sep 4;369(6508):1261-1265
pubmed: 32753553
Epidemiol Infect. 2013 Feb;141(2):425-30
pubmed: 22717050
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
J Virol. 2020 Oct 27;94(22):
pubmed: 32847856
Avian Dis. 2003 Jan-Mar;47(1):149-53
pubmed: 12713170
Parasitol Res. 2014 Oct;113(10):3517-33
pubmed: 25141814
Vet Parasitol. 2010 Dec 15;174(3-4):355-8
pubmed: 20943320
Parasitol Today. 1998 May;14(5):186-92
pubmed: 17040748
Infect Immun. 2003 Feb;71(2):1001-7
pubmed: 12540584
Vaccines (Basel). 2019 Jul 28;7(3):
pubmed: 31357707
Vet Parasitol. 2001 May 9;97(1):65-76
pubmed: 11337128
Nat Methods. 2012 Jul 30;9(8):772
pubmed: 22847109
AIMS Microbiol. 2020 Sep 24;6(3):350-360
pubmed: 33029570
J Med Virol. 2020 Jun;92(6):595-601
pubmed: 32100877
BMC Bioinformatics. 2019 Sep 14;20(1):473
pubmed: 31521110
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Sci Signal. 2021 Jan 12;14(665):
pubmed: 33436497
Microbiol Mol Biol Rev. 1999 Mar;63(1):128-48
pubmed: 10066833
Science. 1987 Aug 14;237(4816):775-7
pubmed: 3616608
J Virol. 2020 Aug 31;94(18):
pubmed: 32661139
Epidemiol Infect. 2001 Apr;126(2):317-21
pubmed: 11349983
Annu Rev Entomol. 2020 Jan 7;65:293-311
pubmed: 31610134
Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):
pubmed: 33658332
Vet Parasitol. 2007 Aug 19;148(1):62-74
pubmed: 17560724
Bioinformatics. 2018 Jul 15;34(14):2490-2492
pubmed: 29506019
Transbound Emerg Dis. 2020 Sep 7;:
pubmed: 32894654
Protein Sci. 2006 Nov;15(11):2507-24
pubmed: 17075131
Nucleic Acids Res. 2016 Jan 4;44(D1):D404-9
pubmed: 26578585
One Health Outlook. 2021 Apr 7;3:7
pubmed: 33834160
Nucleic Acids Res. 2017 Jul 3;45(W1):W374-W380
pubmed: 28472330
Virus Evol. 2015 May 26;1(1):vev003
pubmed: 27774277
Comput Struct Biotechnol J. 2020 Jan 23;18:253-257
pubmed: 33489003
Molecules. 2020 Nov 06;25(21):
pubmed: 33172077
Trop Med Infect Dis. 2018 Jan 03;3(1):
pubmed: 30274402
J Leukoc Biol. 2019 Sep;106(3):695-701
pubmed: 31063609
Nucleic Acids Res. 2020 Jan 8;48(D1):D335-D343
pubmed: 31691821
Trends Parasitol. 2010 Apr;26(4):197-204
pubmed: 20185369
Front Cell Infect Microbiol. 2017 Jul 26;7:339
pubmed: 28798904
Nature. 2020 May;581(7807):221-224
pubmed: 32225175
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
Transbound Emerg Dis. 2015 Apr;62(2):174-82
pubmed: 23702314
Bioinformatics. 2014 May 1;30(9):1314-5
pubmed: 24413526
Nucleic Acids Res. 2019 Jul 2;47(W1):W338-W344
pubmed: 31114883
Med Biol. 1975 Oct;53(5):621-4
pubmed: 1207194
Bioinformatics. 2013 Sep 15;29(18):2357-9
pubmed: 23842804
Trends Parasitol. 2007 Sep;23(9):427-33
pubmed: 17656154
Parasit Vectors. 2019 Apr 3;12(1):154
pubmed: 30944017
Proteins. 2002 Aug 1;48(2):227-41
pubmed: 12112692
Vet Parasitol. 2010 Feb 10;167(2-4):95-107
pubmed: 19811876
Parasit Vectors. 2016 Apr 26;9:237
pubmed: 27117813
J Clin Invest. 2010 Sep;120(9):3179-90
pubmed: 20739755
Mol Biol Evol. 2018 Mar 1;35(3):773-777
pubmed: 29301006
Emerg Microbes Infect. 2020 Dec;9(1):2013-2019
pubmed: 32867625
ACS Nano. 2020 Apr 28;14(4):5143-5147
pubmed: 32286790
Cell Host Microbe. 2020 May 13;27(5):704-709.e2
pubmed: 32259477
Sci Rep. 2020 Oct 5;10(1):16471
pubmed: 33020502
Trends Parasitol. 2019 Apr;35(4):316-328
pubmed: 30711437
Parasit Vectors. 2021 Jan 22;14(1):76
pubmed: 33482887
Science. 2020 May 29;368(6494):1016-1020
pubmed: 32269068
Lancet. 2020 Oct 31;396(10260):1396-1397
pubmed: 33129391
Nucleic Acids Res. 2019 Jul 2;47(W1):W636-W641
pubmed: 30976793
Science. 1974 Sep 6;185(4154):862-4
pubmed: 4843792
Parasit Vectors. 2018 Jan 18;11(1):43
pubmed: 29347954
PLoS Genet. 2012;8(7):e1002764
pubmed: 22807683
Nucleic Acids Res. 2020 Jan 8;48(D1):D689-D695
pubmed: 31598706
Front Cell Infect Microbiol. 2017 Mar 13;7:74
pubmed: 28348982
Int J Parasitol. 1994 Dec;24(8):1285-91
pubmed: 7729981
Lancet Infect Dis. 2020 Aug;20(8):892-893
pubmed: 32628907
Nucleic Acids Res. 2001 Jan 1;29(1):221-2
pubmed: 11125097
Parasit Vectors. 2015 Oct 15;8:538
pubmed: 26467109
Glob Chall. 2017 Jan 10;1(1):33-46
pubmed: 31565258
AIDS. 1993 Mar;7(3):341-7
pubmed: 8471196
Viruses. 2020 Apr 30;12(5):
pubmed: 32365751
J Chem Inf Model. 2011 Oct 24;51(10):2778-86
pubmed: 21919503
Acta Crystallogr D Struct Biol. 2017 Aug 1;73(Pt 8):628-640
pubmed: 28777078
Sci Rep. 2020 Jul 17;10(1):11915
pubmed: 32681089
Parasit Vectors. 2020 Aug 10;13(1):409
pubmed: 32778178
Nature. 2020 May;581(7807):215-220
pubmed: 32225176
J Mol Biol. 1990 Oct 5;215(3):403-10
pubmed: 2231712
Cell Res. 2020 Aug;30(8):670-677
pubmed: 32636454
Pathogens. 2020 Aug 17;9(8):
pubmed: 32824571