The impact of susceptibility correction on diffusion metrics in adolescents.
Adolescents
Brain
Diffusion tensor imaging
Magnetic resonance imaging
Susceptibility correction
Tractography
Journal
Pediatric radiology
ISSN: 1432-1998
Titre abrégé: Pediatr Radiol
Pays: Germany
ID NLM: 0365332
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
03
06
2020
accepted:
03
02
2021
revised:
16
09
2020
pubmed:
25
4
2021
medline:
18
11
2021
entrez:
24
4
2021
Statut:
ppublish
Résumé
Diffusion tensor imaging is a widely used imaging method of brain white matter, but it is prone to imaging artifacts. The data corrections can affect the measured values. To explore the impact of susceptibility correction on diffusion metrics. A cohort of 27 healthy adolescents (18 boys, 9 girls, mean age 12.7 years) underwent 3-T MRI, and we collected two diffusion data sets (anterior-posterior). The data were processed both with and without susceptibility artifact correction. We derived fractional anisotropy, mean diffusivity and histogram data of fiber length distribution from both the corrected and uncorrected data, which were collected from the corpus callosum, corticospinal tract and cingulum bilaterally. Fractional anisotropy and mean diffusivity values significantly differed when comparing the pathways in all measured tracts. The fractional anisotropy values were lower and the mean diffusivity values higher in the susceptibility-corrected data than in the uncorrected data. We found a significant difference in total tract length in the corpus callosum and the corticospinal tract. This study indicates that susceptibility correction has a significant effect on measured fractional anisotropy, and on mean diffusivity values and tract lengths. To receive reliable and comparable results, the correction should be used systematically.
Sections du résumé
BACKGROUND
BACKGROUND
Diffusion tensor imaging is a widely used imaging method of brain white matter, but it is prone to imaging artifacts. The data corrections can affect the measured values.
OBJECTIVE
OBJECTIVE
To explore the impact of susceptibility correction on diffusion metrics.
MATERIALS AND METHODS
METHODS
A cohort of 27 healthy adolescents (18 boys, 9 girls, mean age 12.7 years) underwent 3-T MRI, and we collected two diffusion data sets (anterior-posterior). The data were processed both with and without susceptibility artifact correction. We derived fractional anisotropy, mean diffusivity and histogram data of fiber length distribution from both the corrected and uncorrected data, which were collected from the corpus callosum, corticospinal tract and cingulum bilaterally.
RESULTS
RESULTS
Fractional anisotropy and mean diffusivity values significantly differed when comparing the pathways in all measured tracts. The fractional anisotropy values were lower and the mean diffusivity values higher in the susceptibility-corrected data than in the uncorrected data. We found a significant difference in total tract length in the corpus callosum and the corticospinal tract.
CONCLUSION
CONCLUSIONS
This study indicates that susceptibility correction has a significant effect on measured fractional anisotropy, and on mean diffusivity values and tract lengths. To receive reliable and comparable results, the correction should be used systematically.
Identifiants
pubmed: 33893847
doi: 10.1007/s00247-021-05000-3
pii: 10.1007/s00247-021-05000-3
pmc: PMC8266789
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1471-1480Investigateurs
Annarilla Ahtola
(A)
Mikael Ekblad
(M)
Satu Ekblad
(S)
Eeva Ekholm
(E)
Linda Grönroos
(L)
Leena Haataja
(L)
Mira Huhtala
(M)
Jere Jaakkola
(J)
Eveliina Joensuu
(E)
Max Karukivi
(M)
Pentti Kero
(P)
Riikka Korja
(R)
Katri Lahti
(K)
Helena Lapinleimu
(H)
Liisa Lehtonen
(L)
Tuomo Lehtonen
(T)
Marika Leppänen
(M)
Annika Lind
(A)
Hanna Manninen
(H)
Mari Koivisto
(M)
Mira Mattson
(M)
Jonna Maunu
(J)
Petriina Munck
(P)
Laura Määttänen
(L)
Pekka Niemi
(P)
Anna Nyman
(A)
Pertti Palo
(P)
Riitta Parkkola
(R)
Liisi Ripatti
(L)
Päivi Rautava
(P)
Katriina Saarinen
(K)
Tiina Saarinen
(T)
Virva Saunavaara
(V)
Sirkku Setänen
(S)
Matti Sillanpää
(M)
Suvi Stolt
(S)
Päivi Tuomikoski-Koiranen
(P)
Timo Tuovinen
(T)
Karoliina Uusitalo
(K)
Anniina Väliaho
(A)
Milla Ylijoki
(M)
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