Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate.

Amino Acids / chemistry Cell Line, Tumor Codon Usage Gene Knockdown Techniques Humans Hydrophobic and Hydrophilic Interactions Multienzyme Complexes / genetics Peptide Chain Elongation, Translational Protein Aggregates / genetics Proteolysis Proteomics RNA Processing, Post-Transcriptional RNA, Messenger / metabolism RNA, Transfer / genetics Uridine / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
15 04 2021
Historique:
received: 18 05 2020
accepted: 05 03 2021
entrez: 16 4 2021
pubmed: 17 4 2021
medline: 4 5 2021
Statut: epublish

Résumé

Regulation of mRNA translation elongation impacts nascent protein synthesis and integrity and plays a critical role in disease establishment. Here, we investigate features linking regulation of codon-dependent translation elongation to protein expression and homeostasis. Using knockdown models of enzymes that catalyze the mcm

Identifiants

DOI: 10.1038/s41467-021-22254-5 PMID: 33859181 PMC: PMC8050329
pubmed: 33859181
doi: 10.1038/s41467-021-22254-5
pii: 10.1038/s41467-021-22254-5
pmc: PMC8050329
doi:

Substances chimiques

Amino Acids 0
Multienzyme Complexes 0
Protein Aggregates 0
RNA, Messenger 0
RNA, Transfer 9014-25-9
Uridine WHI7HQ7H85

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2170

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Auteurs

Francesca Rapino (F)

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium. Francesca.Rapino@uliege.be.
GIGA-Institute, University of Liège, Liège, Belgium. Francesca.Rapino@uliege.be.
University of Liège, Liège, Belgium. Francesca.Rapino@uliege.be.
Department of Radiation Oncology (Maastro), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands. Francesca.Rapino@uliege.be.

Zhaoli Zhou (Z)

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.
GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.

Ana Maria Roncero Sanchez (AM)

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.
GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.

Marc Joiret (M)

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.
GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
Biomechanics Research Unit, University of Liège, Liège, Belgium.

Christian Seca (C)

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.
GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.

Najla El Hachem (N)

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.
GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
ORCID: 0000-0002-4180-3016

Gianluca Valenti (G)

University of Liège, Liège, Belgium.
Unité de Recherche Transitions, University of Liège, Liège, Belgium.

Sara Latini (S)

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.
GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
ORCID: 0000-0002-2353-3155

Kateryna Shostak (K)

GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
Laboratory of Medical Chemistry, University of Liège, Liège, Belgium.

Liesbet Geris (L)

GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
Biomechanics Research Unit, University of Liège, Liège, Belgium.
ORCID: 0000-0002-8180-1445

Ping Li (P)

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.

Gang Huang (G)

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.

Gabriel Mazzucchelli (G)

GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
Mass Spectrometry Laboratory, System Biology and Chemical Biology, University of Liège, Liège, Belgium.

Dominique Baiwir (D)

GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
Mass Spectrometry Laboratory, System Biology and Chemical Biology, University of Liège, Liège, Belgium.
ORCID: 0000-0002-1622-0118

Christophe J Desmet (CJ)

GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
Laboratory of Cellular and Molecular Immunology, University of Liège, Liège, Belgium.
Faculty of Veterinary Medicine, University of Liege, Liege, Belgium.

Alain Chariot (A)

GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
Laboratory of Medical Chemistry, University of Liège, Liège, Belgium.
WELBIO, University of Liege, Liege, Belgium.

Michel Georges (M)

GIGA-Institute, University of Liège, Liège, Belgium.
University of Liège, Liège, Belgium.
Faculty of Veterinary Medicine, University of Liege, Liege, Belgium.
Unit of Animal Genomics, University of Liège, Liège, Belgium.

Pierre Close (P)

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium. Pierre.Close@uliege.be.
GIGA-Institute, University of Liège, Liège, Belgium. Pierre.Close@uliege.be.
University of Liège, Liège, Belgium. Pierre.Close@uliege.be.
WELBIO, University of Liege, Liege, Belgium. Pierre.Close@uliege.be.
ORCID: 0000-0002-8844-9616

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Acides aminés › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Code génétique › Usage des codons › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Métabolisme › Biosynthèse des peptides › Élongation de la traduction › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Structures macromoléculaires › Agrégats de protéines › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Métabolisme › Protéolyse › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN de transfert › Wobble tRNA modification and hydrophilic amino...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › Wobble tRNA modification and hydrophilic amino...