Association of Plasma Hemoglobin A1c with Improvement of Cognitive Functions by Probiotic Bifidobacterium breve Supplementation in Healthy Adults with Mild Cognitive Impairment.
Bifidobacterium
HbA1c
clinical trial
dementia
memory
mild cognitive impairment
probiotics
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2021
2021
Historique:
pubmed:
6
4
2021
medline:
7
9
2021
entrez:
5
4
2021
Statut:
ppublish
Résumé
We demonstrated the benefit of the probiotic strain, Bifidobacterium breve MCC1274 (synonym B. breve A1), at improving cognition in our previous double-blind, placebo-controlled clinical study. Analysis of the association of blood parameters changes with the improvement of cognitive function revealed an inverse correlation of HbA1c with total RBANS score amelioration after the study only in the probiotic group (ρ= -0.4218, p = 0.0067). A stratified analysis based on baseline HbA1c with a median value showed a more remarkable benefit by the probiotic supplementation in the higher median subgroup. These data support the mechanism of anti-inflammation in improving cognition by the probiotic strain.
Identifiants
pubmed: 33814441
pii: JAD201488
doi: 10.3233/JAD-201488
pmc: PMC8203240
doi:
Substances chimiques
Glycated Hemoglobin A
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
493-497Références
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