Intratumoral Heterogeneity in Uveal Melanoma.
Biopsy
Prognosis
Tumor heterogeneity
Uveal melanoma
Journal
Ocular oncology and pathology
ISSN: 2296-4681
Titre abrégé: Ocul Oncol Pathol
Pays: Switzerland
ID NLM: 101656139
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
19
01
2020
accepted:
07
05
2020
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
3
4
2021
Statut:
ppublish
Résumé
Tumor biopsies in uveal melanoma (UM) serve mainly the purpose of prognostication and assessment of individual metastatic risk, but can be used for diagnosis in selected cases. The importance of precise information is paramount for selecting adequate surveillance protocols, patient counseling, and optimization of treatment strategies. However, intratumoral heterogeneity and sample representativity are major concerns and can interfere with the correct prediction of the patient's prognosis. We report a series of cases of UM with distinct morphologically identifiable areas, highlighting the differences in clinical behavior, as well as histopathological and genetic features.
Identifiants
pubmed: 33796512
doi: 10.1159/000508517
pii: oop-0007-0017
pmc: PMC7989676
doi:
Types de publication
Case Reports
Langues
eng
Pagination
17-25Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.
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