Mesenchymal Stromal Cell-Derived Extracellular Vesicles Regulate the Mitochondrial Metabolism
extracellular vesicle
mesenchymal stem cell
miRNA
mitochondrial dysfunction
mitochondrial metabolism
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
10
2020
accepted:
14
01
2021
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
15
9
2021
Statut:
epublish
Résumé
Mesenchymal stromal cells (MSCs) are the most commonly tested adult progenitor cells in regenerative medicine. They stimulate tissue repair primarily through the secretion of immune-regulatory and pro-regenerative factors. There is increasing evidence that most of these factors are carried on extracellular vesicles (EVs) that are released by MSCs, either spontaneously or after activation. Exosomes and microvesicles are the most investigated types of EVs that act through uptake by target cells and cargo release inside the cytoplasm or through interactions with receptors expressed on target cells to stimulate downstream intracellular pathways. They convey different types of molecules, including proteins, lipids and acid nucleics among which, miRNAs are the most widely studied. The cargo of EVs can be impacted by the culture or environmental conditions that MSCs encounter and by changes in the energy metabolism that regulate the functional properties of MSCs. On the other hand, MSC-derived EVs are also reported to impact the metabolism of target cells. In the present review, we discuss the role of MSC-EVs in the regulation of the energy metabolism and oxidative stress of target cells and tissues with a focus on the role of miRNAs.
Identifiants
pubmed: 33796099
doi: 10.3389/fimmu.2021.623973
pmc: PMC8007981
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
623973Informations de copyright
Copyright © 2021 Loussouarn, Pers, Bony, Jorgensen and Noël.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Trends Mol Med. 2019 Feb;25(2):149-163
pubmed: 30711482
Stem Cells Transl Med. 2017 Jan;6(1):209-222
pubmed: 28170197
J Cell Biochem. 2014 Jan;115(1):93-101
pubmed: 23904244
Nat Med. 2015 Nov;21(11):1290-7
pubmed: 26501192
Stem Cells. 2006 May;24(5):1294-301
pubmed: 16410387
Biochem Soc Trans. 2016 Oct 15;44(5):1499-1505
pubmed: 27911732
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E799-806
pubmed: 20086200
Aging (Albany NY). 2016 Mar;8(3):484-505
pubmed: 26959556
Oxid Med Cell Longev. 2018 Jun 24;2018:2910643
pubmed: 30034574
Neuro Oncol. 2010 Nov;12(11):1102-12
pubmed: 20667897
Genetics. 2017 Nov;207(3):843-871
pubmed: 29097398
Cell Mol Life Sci. 2012 Dec;69(23):4017-27
pubmed: 22773120
FEBS Lett. 2015 Dec 21;589(24 Pt B):4071-8
pubmed: 26632510
Int J Biochem Cell Biol. 2015 Jun;63:55-9
pubmed: 25666556
Nat Commun. 2017 Oct 17;8(1):983
pubmed: 29042548
Biochim Biophys Acta. 2013 Feb;1833(2):410-6
pubmed: 22445420
J Transl Med. 2019 May 2;17(1):142
pubmed: 31046805
Biochimie. 2013 Dec;95(12):2229-34
pubmed: 23685070
Cell Transplant. 2007;16(5):555-62
pubmed: 17708345
Cancer Res. 2008 Jul 1;68(13):5198-205
pubmed: 18593920
Cells. 2020 Oct 11;9(10):
pubmed: 33050562
Oxid Med Cell Longev. 2016;2016:2989076
pubmed: 27413419
FEBS J. 2018 Mar;285(6):1033-1050
pubmed: 29399967
Exp Hematol. 1976 Sep;4(5):267-74
pubmed: 976387
PLoS Genet. 2015 Dec 28;11(12):e1005726
pubmed: 26710269
Curr Med Chem. 2015;22(20):2468-79
pubmed: 25973983
PLoS One. 2016 Sep 09;11(9):e0162417
pubmed: 27611075
J Cell Mol Med. 2017 Nov;21(11):2963-2973
pubmed: 28544786
Front Immunol. 2019 May 08;10:977
pubmed: 31139179
Front Cell Neurosci. 2019 Feb 14;13:51
pubmed: 30837842
Int J Mol Sci. 2019 Oct 26;20(21):
pubmed: 31717786
Cells. 2019 Nov 21;8(12):
pubmed: 31766319
Biochem Soc Trans. 2002 Nov;30(Pt 6):1059-64
pubmed: 12440972
Drug Metab Rev. 2007;39(2-3):443-55
pubmed: 17786631
Cytotherapy. 2019 Oct;21(10):1019-1024
pubmed: 31526643
J Cell Physiol. 2013 Sep;228(9):1802-18
pubmed: 23629871
Oxid Med Cell Longev. 2018 Aug 7;2018:4971261
pubmed: 30159114
FEBS Lett. 2015 Jun 4;589(13):1391-8
pubmed: 25937124
Stem Cells. 2011 May;29(5):812-24
pubmed: 21433223
J Hepatol. 2018 Jun;68(6):1272-1285
pubmed: 29425678
Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1659-1670
pubmed: 29141446
Cell Commun Signal. 2020 Sep 11;18(1):149
pubmed: 32917227
Cell Death Dis. 2019 Feb 12;10(2):137
pubmed: 30755591
Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):711-23
pubmed: 23168274
Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L723-L737
pubmed: 30652491
Stem Cell Res Ther. 2019 Sep 3;10(1):281
pubmed: 31481100
Front Endocrinol (Lausanne). 2018 Aug 03;9:402
pubmed: 30123182
J Cell Biochem. 2012 Apr;113(4):1104-10
pubmed: 22135235
Mol Cell. 2011 Jun 10;42(5):561-8
pubmed: 21658599
Exp Mol Pathol. 2007 Aug;83(1):84-92
pubmed: 17239370
Stem Cells Int. 2016;2016:2093940
pubmed: 27799943
J Neurooncol. 2013 May;113(1):1-11
pubmed: 23456661
Circ Res. 2015 Jul 17;117(3):266-78
pubmed: 26002865
Annu Rev Genomics Hum Genet. 2017 Aug 31;18:257-275
pubmed: 28415858
J Sport Health Sci. 2020 Sep;9(5):405-414
pubmed: 32780693
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):239-50
pubmed: 22436747
RNA. 2004 Feb;10(2):185-91
pubmed: 14730017
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):664-70
pubmed: 20036212
Curr Opin Lipidol. 2011 Apr;22(2):86-92
pubmed: 21178770
Cell Transplant. 2014;23(9):1045-59
pubmed: 23676629
Cell Rep. 2016 Jan 12;14(2):234-42
pubmed: 26748705
ACS Nano. 2020 Apr 28;14(4):4014-4026
pubmed: 32212674
Cell Physiol Biochem. 2015;37(1):375-86
pubmed: 26316084
Int J Mol Sci. 2016 May 18;17(5):
pubmed: 27213336
Stem Cell Res Ther. 2016 Aug 31;7(1):125
pubmed: 27581859
Trends Biochem Sci. 2020 Jul;45(7):564-577
pubmed: 32291139
Int J Mol Sci. 2019 Dec 04;20(24):
pubmed: 31817101
Biochim Biophys Acta. 2010 Nov;1803(11):1231-43
pubmed: 20619301
EMBO J. 2004 Oct 13;23(20):4051-60
pubmed: 15372072
Toxicol Appl Pharmacol. 2019 Dec 15;385:114788
pubmed: 31678243
Circ Res. 2012 Jun 8;110(12):1596-603
pubmed: 22518031
Curr Biol. 2006 Jul 25;16(14):R551-60
pubmed: 16860735
Cell Mol Life Sci. 2017 Feb;74(4):631-646
pubmed: 27563705
Physiol Rev. 2002 Jan;82(1):47-95
pubmed: 11773609
PLoS One. 2018 Feb 14;13(2):e0191616
pubmed: 29444190
Genes (Basel). 2014 Sep 26;5(4):865-86
pubmed: 25264560
J Clin Invest. 2015 Jan;125(1):141-56
pubmed: 25415439
Tissue Eng Part B Rev. 2012 Apr;18(2):101-15
pubmed: 21995703
Trends Endocrinol Metab. 2016 Feb;27(2):105-117
pubmed: 26754340
Front Physiol. 2018 Nov 13;9:1572
pubmed: 30555336
Pathophysiology. 2017 Sep;24(3):107-122
pubmed: 28400074
Stem Cells Transl Med. 2018 Oct;7(10):748-758
pubmed: 30063300
Trends Mol Med. 2017 Mar;23(3):201-215
pubmed: 28188102
Cell Metab. 2006 Feb;3(2):87-98
pubmed: 16459310
Cancer Res. 2019 Jul 1;79(13):3294-3305
pubmed: 31101765
Can J Physiol Pharmacol. 2017 Oct;95(10):1156-1162
pubmed: 28467860
Free Radic Biol Med. 2013 Sep;64:12-9
pubmed: 23792138
Annu Rev Pathol. 2010;5:297-348
pubmed: 20078222
Cell Mol Neurobiol. 2016 Apr;36(3):301-12
pubmed: 27053351
Stem Cell Res Ther. 2018 Nov 21;9(1):320
pubmed: 30463593
Annu Rev Cell Dev Biol. 2014;30:255-89
pubmed: 25288114
Stem Cells Transl Med. 2020 Sep;9(9):985-1006
pubmed: 32497410
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Front Cell Dev Biol. 2020 Dec 07;8:603292
pubmed: 33365311
J Cell Sci. 2006 Jun 1;119(Pt 11):2204-13
pubmed: 16684817
Nat Rev Cardiol. 2018 Oct;15(10):585-600
pubmed: 29872165
Cell. 2006 Sep 8;126(5):941-54
pubmed: 16959573
Biochem Biophys Res Commun. 2018 Jan 1;495(1):46-52
pubmed: 29097210
Korean J Intern Med. 2015 Sep;30(5):580-9
pubmed: 26354051
Front Physiol. 2017 Dec 12;8:1028
pubmed: 29311962
Tumour Biol. 2017 Feb;39(2):1010428317691429
pubmed: 28218035
Nature. 2009 Apr 9;458(7239):762-5
pubmed: 19219026
J Zhejiang Univ Sci B. 2019 Mar.;20(3):219-237
pubmed: 30829010
Mol Cell Proteomics. 2011 Jul;10(7):M110.005322
pubmed: 21512034
FASEB J. 2019 Feb;33(2):1695-1710
pubmed: 30226809
Biochim Biophys Acta. 2010 Feb;1797(2):113-28
pubmed: 19761752
Mol Cell Biol. 2008 Aug;28(16):5106-19
pubmed: 18559422
Mol Cell Pharmacol. 2011;3(3):125-134
pubmed: 22792411
Stem Cell Res Ther. 2019 Sep 23;10(1):288
pubmed: 31547882
J Clin Med. 2020 Aug 11;9(8):
pubmed: 32796538
Front Physiol. 2018 Sep 21;9:1291
pubmed: 30298016
Stem Cells. 2016 Feb;34(2):483-92
pubmed: 26661518