Differential capability of Bacillus thuringiensis Cry1Ac protoxin and toxin to induce in vivo activation of dendritic cells and B lymphocytes.
Animals
Antigen Presentation
B-Lymphocytes
/ immunology
Bacillus thuringiensis
/ immunology
Bacillus thuringiensis Toxins
/ administration & dosage
Dendritic Cells
/ immunology
Endotoxins
/ administration & dosage
Female
Hemolysin Proteins
/ administration & dosage
Lymphocyte Activation
Mice
Recombinant Proteins
/ administration & dosage
Cry1Ac protoxin
Cry1Ac toxin
Dendritic cell activation
Intradermal administration
Polyclonal B cell Activation
Journal
Developmental and comparative immunology
ISSN: 1879-0089
Titre abrégé: Dev Comp Immunol
Pays: United States
ID NLM: 7708205
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
25
10
2020
revised:
08
03
2021
accepted:
09
03
2021
pubmed:
27
3
2021
medline:
25
2
2022
entrez:
26
3
2021
Statut:
ppublish
Résumé
The insecticidal Bacillus thuringiensis protein Cry1Ac is produced as a protoxin and becomes activated to a toxin when ingested by larvae. Both proteins are immunogenic and able to activate macrophages. The proposed mechanism of immunostimulation by Cry1Ac protoxin has been related to its capacity to activate antigen-presenting cells (APC), but its ability to activate dendritic cells (DC) has not been explored. Here we evaluated, in the popliteal lymph nodes (PLN), spleen and peritoneum, the activation of DC CD11c
Identifiants
pubmed: 33766585
pii: S0145-305X(21)00079-3
doi: 10.1016/j.dci.2021.104071
pii:
doi:
Substances chimiques
Bacillus thuringiensis Toxins
0
Endotoxins
0
Hemolysin Proteins
0
Recombinant Proteins
0
insecticidal crystal protein, Bacillus Thuringiensis
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104071Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.