An overview of some potential immunotherapeutic options against COVID-19.
ACE2-Fc
Antibodies
COVID-19
Immunotherapy
SARS-CoV2
Vaccines
Journal
International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
05
12
2020
revised:
15
02
2021
accepted:
15
02
2021
pubmed:
26
3
2021
medline:
27
5
2021
entrez:
25
3
2021
Statut:
ppublish
Résumé
After the advent of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in the late 2019, the resulting severe and pernicious syndrome (COVID-19) immediately was deployed all around the world. To date, despite relentless efforts to control the disease by drug repurposing, there is no approved specific therapy for COVID-19. Given the role of innate and acquired immune components in the control and elimination of viral infections and inflammatory mutilations during SARS-CoV2 pathogenesis, immunotherapeutic strategies appear to be beneficent. Passive immunotherapies such as convalescent plasma, which has received much attention especially in severe cases, as well as suppressing inflammatory cytokines, interferon administration, inhibition of kinases and complement cascade, virus neutralization with key engineered products, cell-based therapies, immunomodulators and anti-inflammatory drugs are among the key immunotherapeutic approaches to deal with COVID-19, which is discussed in this review. Also, details of leading COVID-19 vaccine candidates as the most potent immunotherapy have been provided. However, despite salient improvements, there is still a lack of completely assured vaccines for universal application. Therefore, adopting proper immunotherapies according to the cytokine pattern and involved immune responses, alongside engineered biologics specially ACE2-Fc to curb SARS-CoV2 infection until achieving a tailored vaccine is probably the best strategy to better manage this pandemic. Therefore, gaining knowledge about the mechanism of action, potential targets, as well as the effectiveness of immune-based approaches to confront COVID-19 in the form of a well-ordered review study is highly momentous.
Identifiants
pubmed: 33765610
pii: S1567-5769(21)00152-1
doi: 10.1016/j.intimp.2021.107516
pmc: PMC7908848
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
Complement Inactivating Agents
0
Cytokines
0
Immunologic Factors
0
Protein Kinase Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107516Subventions
Organisme : Department of Health
ID : PB-PG-0906-10134
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Références
Emerg Microbes Infect. 2020 Dec;9(1):382-385
pubmed: 32065055
Structure. 2016 Mar 1;24(3):401-11
pubmed: 26853940
Am J Respir Crit Care Med. 2011 Jul 15;184(2):259-68
pubmed: 21474645
Nat Commun. 2014 May 06;5:3594
pubmed: 24800825
J Allergy Clin Immunol. 2020 Jul;146(1):215-217
pubmed: 32417135
Emerg Infect Dis. 2005 Jul;11(7):1016-20
pubmed: 16022774
Clin Transl Sci. 2020 Sep;13(5):835-837
pubmed: 32420691
J Clin Invest. 2020 Jun 1;130(6):2757-2765
pubmed: 32254064
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3621-6
pubmed: 26976597
Antivir Chem Chemother. 2009;19(4):151-6
pubmed: 19374142
Nat Rev Rheumatol. 2014 Dec;10(12):720-7
pubmed: 25136784
J Clin Invest. 2017 Apr 3;127(4):1338-1352
pubmed: 28240606
Lancet. 2020 May 30;395(10238):1695-1704
pubmed: 32401715
Mediators Inflamm. 2015;2015:568543
pubmed: 25838639
Methods Mol Biol. 2019;1911:395-419
pubmed: 30593641
J Med Virol. 2005 Feb;75(2):185-94
pubmed: 15602737
J Clin Invest. 2018 Oct 1;128(10):4654-4668
pubmed: 30198904
Mol Cell Pediatr. 2016 Dec;3(1):29
pubmed: 27480877
Cell Host Microbe. 2016 Feb 10;19(2):181-93
pubmed: 26867177
Cleve Clin J Med. 2020 Jun 30;87(7):389-393
pubmed: 32393592
Int J Mol Sci. 2017 Nov 14;18(11):
pubmed: 29135922
PLoS One. 2015 Apr 29;10(4):e0124593
pubmed: 25923215
J Clin Invest. 2009 Apr;119(4):997-1007
pubmed: 19287090
J Virol. 2009 Nov;83(21):11385-90
pubmed: 19710146
Virol Sin. 2020 Jun;35(3):266-271
pubmed: 32125642
Nature. 2020 Jul;583(7815):290-295
pubmed: 32422645
Nat Med. 2020 Apr;26(4):453-455
pubmed: 32284614
Crit Care Med. 2012 Jan;40(1):90-7
pubmed: 21926600
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
J Allergy Clin Immunol. 2001 Dec;108(6):970-5
pubmed: 11742275
J Clin Virol. 2020 Jun;127:104388
pubmed: 32361326
Gastroenterology. 2013 Feb;144(2):392-401
pubmed: 23103614
Nat Med. 2020 Oct;26(10):1609-1615
pubmed: 32747830
Clin Immunol. 2005 Jan;114(1):30-41
pubmed: 15596407
JCI Insight. 2020 Aug 6;5(15):
pubmed: 32554923
Blood. 2016 Mar 31;127(13):1666-75
pubmed: 26825707
Cell Res. 2010 May;20(5):510-8
pubmed: 20368733
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Cell Immunol. 2009;258(1):18-28
pubmed: 19345936
Cancer Immunol Res. 2019 Mar;7(3):363-375
pubmed: 30651290
Lancet Rheumatol. 2020 Jul;2(7):e428-e436
pubmed: 32835246
Asian Pac J Allergy Immunol. 2020 Mar;38(1):10-18
pubmed: 32134278
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
Arch Rheumatol. 2018 Mar 23;33(4):389-394
pubmed: 30874247
Nat Rev Immunol. 2013 Mar;13(3):176-89
pubmed: 23411799
Clin Microbiol Infect. 2004 Dec;10(12):1062-6
pubmed: 15606632
Sci Rep. 2015 Aug 14;5:13135
pubmed: 26272519
J Microbiol Biotechnol. 2019 Apr 28;29(4):651-657
pubmed: 30856707
J Infect Dis. 2004 Jul 15;190(2):379-86
pubmed: 15216476
Exp Lung Res. 2006 Mar-Apr;32(3-4):81-97
pubmed: 16754474
Arthritis Rheum. 2003 Dec;48(12):3497-502
pubmed: 14674000
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
Sci Rep. 2017 Aug 21;7(1):8390
pubmed: 28827559
Antivir Ther. 2006;11(8):1021-30
pubmed: 17302372
Eur J Clin Microbiol Infect Dis. 2005 Sep;24(9):583-91
pubmed: 16172857
Cytokine. 2020 Sep;133:155143
pubmed: 32460144
Nat Rev Microbiol. 2009 Mar;7(3):226-36
pubmed: 19198616
Nature. 2003 Nov 27;426(6965):450-4
pubmed: 14647384
F1000Res. 2020 Jan 31;9:72
pubmed: 32117569
Antiviral Res. 2015 Mar;115:21-38
pubmed: 25554382
JCI Insight. 2019 Feb 21;4(4):
pubmed: 30830861
Lancet. 2020 Feb 15;395(10223):e30-e31
pubmed: 32032529
J Biol Chem. 2004 Jan 30;279(5):3197-201
pubmed: 14670965
Science. 2020 Jul 3;369(6499):77-81
pubmed: 32376603
Transfusion. 2012 May;52 Suppl 1:9S-19S
pubmed: 22578375
Eur J Immunol. 2015 Jan;45(1):250-9
pubmed: 25316442
Viruses. 2020 Feb 25;12(3):
pubmed: 32106567
J Immunother Cancer. 2018 Jun 15;6(1):56
pubmed: 29907163
Nat Med. 2020 Jun;26(6):845-848
pubmed: 32350462
Vox Sang. 2020 Aug;115(6):488-494
pubmed: 32240545
J Med Virol. 2020 Sep;92(9):1495-1500
pubmed: 32410266
Am J Respir Crit Care Med. 2002 Jul 15;166(2):138-43
pubmed: 12119223
Sci Rep. 2014 Jul 11;4:5672
pubmed: 25012067
Ther Clin Risk Manag. 2019 Feb 28;15:323-335
pubmed: 30880998
Nat Rev Immunol. 2020 Jun;20(6):343-344
pubmed: 32327719
J Gen Virol. 2000 Apr;81(Pt 4):853-79
pubmed: 10725411
Trends Immunol. 2009 Dec;30(12):557-61
pubmed: 19786366
Cardiovasc Res. 2019 Jul 1;115(8):1266-1285
pubmed: 30918936
Commun Biol. 2020 Mar 4;3(1):96
pubmed: 32132640
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9804-9
pubmed: 15210961
Cell Mol Immunol. 2010 Mar;7(2):100-3
pubmed: 20154703
Science. 2020 Aug 7;369(6504):712-717
pubmed: 32527928
ACS Chem Neurosci. 2020 Apr 1;11(7):995-998
pubmed: 32167747
Blood. 2008 Feb 1;111(3):1327-33
pubmed: 17951526
Respir Res. 2014 Apr 04;15:39
pubmed: 24708472
Virology. 2014 Apr;454-455:157-68
pubmed: 24725942
Immun Ageing. 2014 Mar 19;11(1):4
pubmed: 24642138
Immunotherapy. 2016 Jul;8(8):959-70
pubmed: 27381687
J Virol. 2005 Jul;79(14):9062-8
pubmed: 15994800
EMBO J. 2005 Apr 20;24(8):1634-43
pubmed: 15791205
Crit Care. 2017 Sep 7;21(1):234
pubmed: 28877748
Nat Rev Immunol. 2020 Jul;20(7):401-403
pubmed: 32533109
PLoS One. 2017 Feb 23;12(2):e0172592
pubmed: 28231275
Vaccines (Basel). 2020 Dec 06;8(4):
pubmed: 33291245
N Engl J Med. 2020 Feb 6;382(6):545-553
pubmed: 32023374
Nat Rev Neurol. 2015 Feb;11(2):80-9
pubmed: 25561275
Int J Biol Sci. 2020 Mar 15;16(10):1718-1723
pubmed: 32226289
Nat Immunol. 2018 Aug;19(8):800-808
pubmed: 30026479
J Virol. 2012 Feb;86(4):2251-8
pubmed: 22171263
J Exp Med. 2005 Mar 21;201(6):971-9
pubmed: 15767371
Virus Res. 2012 Apr;165(1):112-7
pubmed: 22349148
Clin Infect Dis. 2021 Jun 1;72(11):e742-e749
pubmed: 32964913
PLoS One. 2012;7(11):e50366
pubmed: 23185609
J Infect. 2020 Aug;81(2):318-356
pubmed: 32283154
Microbes Infect. 2020 Mar;22(2):74-79
pubmed: 32017984
J Biol Chem. 2008 Feb 8;283(6):3272-3280
pubmed: 18055455
J Immunol. 1998 Oct 1;161(7):3781-90
pubmed: 9759905
N Engl J Med. 2007 Sep 13;357(11):1162-3
pubmed: 17855683
J Virol. 2015 Jun;89(12):6264-74
pubmed: 25833053
Pathol Int. 2003 Mar;53(3):133-45
pubmed: 12608894
J Pharm Pharmacol. 2016 Mar;68(3):406-20
pubmed: 26898166
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9530-5
pubmed: 16772384
Crit Care Med. 2000 Jan;28(1):1-7
pubmed: 10667491
Aging Dis. 2020 Mar 9;11(2):216-228
pubmed: 32257537
J Clin Exp Hepatol. 2020 Nov-Dec;10(6):610-621
pubmed: 32837093
Tissue Eng Part B Rev. 2017 Dec;23(6):515-528
pubmed: 28490258
Cell Discov. 2020 Mar 16;6:14
pubmed: 32194980
J Clin Invest. 2020 Nov 2;130(11):6151-6157
pubmed: 32759504
Microorganisms. 2021 Jan 07;9(1):
pubmed: 33430200
Nat Rev Immunol. 2020 Oct;20(10):615-632
pubmed: 32887954
Stem Cells Transl Med. 2015 Oct;4(10):1199-213
pubmed: 26285659
Int Immunopharmacol. 2020 Jun;83:106455
pubmed: 32272396
Int J Cell Cloning. 1990 Jan;8 Suppl 1:35-44; discussion 44-5
pubmed: 2157777
Antiviral Res. 2018 Jul;155:67-75
pubmed: 29753658
Nature. 2018 Mar 28;555(7698):604-610
pubmed: 29595767
Nature. 2005 Jul 7;436(7047):112-6
pubmed: 16001071
J Exp Med. 2010 Jan 18;207(1):173-87
pubmed: 20038598
Nat Nanotechnol. 2020 Aug;15(8):630-645
pubmed: 32661375
Transfusion. 2014 Dec;54(12):3247-51
pubmed: 25403825
Front Med (Lausanne). 2021 Jan 13;7:563893
pubmed: 33521006
Adv Virus Res. 2011;81:85-164
pubmed: 22094080
Surgery. 2020 Mar;167(3):628-630
pubmed: 31623855
Sci Adv. 2019 Apr 10;5(4):eaav4580
pubmed: 30989115
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1371-9
pubmed: 23530214
Lancet Infect Dis. 2020 Apr;20(4):400-402
pubmed: 32113509
Expert Rev Vaccines. 2011 Apr;10(4):499-511
pubmed: 21506647
Lancet Rheumatol. 2020 Jul;2(7):e393-e400
pubmed: 32835245
Immunity. 2019 Apr 16;50(4):907-923
pubmed: 30995506
Zhonghua Shao Shang Za Zhi. 2020 Aug 20;36(8):691-697
pubmed: 32174095
Cell Rep Med. 2020 May 19;1(2):100016
pubmed: 32562483
Sci Rep. 2016 Jan 27;6:19840
pubmed: 26813885
Ecancermedicalscience. 2020 Mar 27;14:1022
pubmed: 32256705
Cell Mol Immunol. 2020 May;17(5):533-535
pubmed: 32203188
Nat Med. 2020 Jul;26(7):1070-1076
pubmed: 32514174
EMBO Mol Med. 2016 Sep 01;8(9):1099-112
pubmed: 27520969
Br J Haematol. 2012 Oct;159(2):135-42
pubmed: 22924410
Nat Rev Microbiol. 2016 Aug;14(8):523-34
pubmed: 27344959
Nat Microbiol. 2020 Apr;5(4):536-544
pubmed: 32123347
Nature. 2020 Dec;588(7836):146-150
pubmed: 32726800
Nat Rev Microbiol. 2019 Mar;17(3):181-192
pubmed: 30531947
Blood. 2019 Feb 14;133(7):697-709
pubmed: 30463995
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
J Immunol. 2014 Jun 15;192(12):5625-34
pubmed: 24808368
Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9490-9496
pubmed: 32253318
Autoimmun Rev. 2020 Jul;19(7):102554
pubmed: 32380316
Front Immunol. 2020 Jun 23;11:1512
pubmed: 32655581
Nat Biotechnol. 2011 May;29(5):428-35
pubmed: 21478876
Curr Opin Virol. 2016 Feb;16:31-40
pubmed: 26812607
Am J Pathol. 2007 Apr;170(4):1136-47
pubmed: 17392154
PLoS Comput Biol. 2018 Mar 21;14(3):e1006069
pubmed: 29561846
Science. 2009 Mar 27;323(5922):1722-5
pubmed: 19264983
Sci China Life Sci. 2020 Mar;63(3):457-460
pubmed: 32009228
Immunol Rev. 2009 Jul;230(1):128-43
pubmed: 19594633
J Clin Immunol. 2007 May;27(3):257-65
pubmed: 17393290
Antiviral Res. 2018 Sep;157:9-17
pubmed: 29983395
Cell Stem Cell. 2017 Aug 3;21(2):166-177
pubmed: 28777943
PLoS One. 2013 May 22;8(5):e63818
pubmed: 23717490
Diabetes Metab Syndr. 2020 Sep - Oct;14(5):971-978
pubmed: 32610262
Stem Cell Rev Rep. 2020 Jun;16(3):434-440
pubmed: 32307653
Cleve Clin J Med. 2020 Jun 8;:
pubmed: 32513808
Ann N Y Acad Sci. 2012 Apr;1253:37-48
pubmed: 22288608
Front Med. 2020 Apr;14(2):185-192
pubmed: 32170560
Transfus Med Hemother. 2018 Oct;45(5):290-298
pubmed: 30498407
Int J Infect Dis. 2020 Jul;96:607-609
pubmed: 32437934
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L178-85
pubmed: 18441099
Protein Cell. 2018 Jan;9(1):63-73
pubmed: 28986820
Stem Cell Res Ther. 2018 Nov 28;9(1):330
pubmed: 30486857
Nat Med. 2005 Aug;11(8):875-9
pubmed: 16007097
Lancet Infect Dis. 2020 Sep;20(9):1012-1013
pubmed: 32251638
Lancet Respir Med. 2020 Apr;8(4):e21
pubmed: 32171062
Crit Care Med. 2014 Feb;42(2):313-21
pubmed: 24105455
Biochem Biophys Res Commun. 2005 Jul 29;333(2):328-35
pubmed: 15961063
Stem Cell Res Ther. 2016 Mar 09;7:37
pubmed: 26960535
J Autoimmun. 2011 Nov;37(3):190-7
pubmed: 21689906
Blood Transfus. 2016 Mar;14(2):152-7
pubmed: 26674811
N Engl J Med. 2020 Apr 23;382(17):e38
pubmed: 32268022
Cancer Lett. 2020 Mar 1;472:175-180
pubmed: 31790761
Clin Immunol. 2020 Nov;220:108598
pubmed: 32961333
Rheumatology (Oxford). 2019 Feb 1;58(Suppl 1):i43-i54
pubmed: 30806709
Curr Med Res Opin. 2004 Jan;20(1):39-40
pubmed: 14741070
Eur Respir J. 2000 May;15(5):895-901
pubmed: 10853855
Int Immunopharmacol. 2020 Nov;88:106924
pubmed: 32877828
Cell. 2015 Sep 24;163(1):230-45
pubmed: 26365490
Blood Adv. 2017 Aug 17;1(19):1533-1536
pubmed: 29296794
Front Immunol. 2020 Jul 03;11:1625
pubmed: 32719685
Lancet Respir Med. 2020 May;8(5):475-481
pubmed: 32105632
Cureus. 2020 Mar 26;12(3):e7423
pubmed: 32337143
Asian Pac J Allergy Immunol. 2020 Mar;38(1):1-9
pubmed: 32105090
Thorax. 2006 Jul;61(7):621-6
pubmed: 16807391
J Card Fail. 2013 Sep;19(9):605-10
pubmed: 24054336
Viral Immunol. 2012 Aug;25(4):277-88
pubmed: 22876772
Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2536-41
pubmed: 14983044
Euro Surveill. 2020 Jul;25(28):
pubmed: 32700671
Am J Respir Crit Care Med. 2018 Mar 15;197(6):757-767
pubmed: 29161116
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
J Infect Dis. 2015 Apr 15;211(8):1208-10
pubmed: 25635120
Pain Physician. 2020 Mar;23(2):E71-E83
pubmed: 32214286
Am J Transplant. 2015 Apr;15(4):1101-4
pubmed: 25716741
Clin Immunol. 2020 May;214:108393
pubmed: 32222466
Sci Rep. 2015 Jul 09;5:11483
pubmed: 26155832
Curr Oncol. 2019 Apr;26(2):e233-e240
pubmed: 31043832
J Virol. 2020 Feb 14;94(5):
pubmed: 31826992
J Infect Dis. 2012 Jul 15;206(2):167-77
pubmed: 22561366
Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1293-9
pubmed: 17720872
Clin Pharmacokinet. 2013 Sep;52(9):783-92
pubmed: 23681967