Antigenic and molecular characterization of low pathogenic avian influenza A(H9N2) viruses in sub-Saharan Africa from 2017 through 2019.
Africa South of the Sahara
Animals
Antibodies, Viral
/ immunology
Antigenic Variation
Chickens
/ virology
Cross Reactions
Evolution, Molecular
Humans
Influenza A Virus, H9N2 Subtype
/ genetics
Influenza in Birds
/ virology
Influenza, Human
/ virology
Phylogeny
Poultry Diseases
/ virology
Virulence
Virus Replication
Africa
Influenza virus
antigenic cartography
one health
phylogeny
Journal
Emerging microbes & infections
ISSN: 2222-1751
Titre abrégé: Emerg Microbes Infect
Pays: United States
ID NLM: 101594885
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
pubmed:
24
3
2021
medline:
17
8
2021
entrez:
23
3
2021
Statut:
ppublish
Résumé
Sub-Saharan Africa was historically considered an animal influenza cold spot, with only sporadic highly pathogenic H5 outbreaks detected over the last 20 years. However, in 2017, low pathogenic avian influenza A(H9N2) viruses were detected in poultry in Sub-Saharan Africa. Molecular, phylogenetic, and antigenic characterization of isolates from Benin, Togo, and Uganda showed that they belonged to the G1 lineage. Isolates from Benin and Togo clustered with viruses previously described in Western Africa, whereas viruses from Uganda were genetically distant and clustered with viruses from the Middle East. Viruses from Benin exhibited decreased cross-reactivity with those from Togo and Uganda, suggesting antigenic drift associated with reduced replication in Calu-3 cells. The viruses exhibited mammalian adaptation markers similar to those of the human strain A/Senegal/0243/2019 (H9N2). Therefore, viral genetic and antigenic surveillance in Africa is of paramount importance to detect further evolution or emergence of new zoonotic strains.
Identifiants
pubmed: 33754959
doi: 10.1080/22221751.2021.1908097
pmc: PMC8057090
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
753-761Références
Lancet. 1999 Sep 11;354(9182):916-7
pubmed: 10489954
Lancet. 2014 Mar 8;383(9920):869
pubmed: 24581684
Epidemiol Infect. 2017 Dec;145(16):3320-3333
pubmed: 29168447
J Virol. 2019 Jan 4;93(2):
pubmed: 30355680
Transbound Emerg Dis. 2018 Feb;65(1):e70-e82
pubmed: 28710829
Viruses. 2019 Jul 05;11(7):
pubmed: 31284485
Nat Commun. 2019 Nov 22;10(1):5310
pubmed: 31757953
Influenza Other Respir Viruses. 2019 Nov;13(6):622-626
pubmed: 31478603
Syst Biol. 2018 Sep 1;67(5):901-904
pubmed: 29718447
Emerg Microbes Infect. 2018 Nov 7;7(1):176
pubmed: 30401826
Epidemiol Infect. 2015 Jul;143(10):2205-12
pubmed: 25530320
J Virol. 2020 Aug 17;94(17):
pubmed: 32611751
Protein Cell. 2014 Apr;5(4):253-7
pubmed: 24622845
PLoS Pathog. 2014 Nov 20;10(11):e1004508
pubmed: 25411973
Science. 2004 Jul 16;305(5682):371-6
pubmed: 15218094
J Clin Microbiol. 2002 Sep;40(9):3256-60
pubmed: 12202562
PLoS One. 2008 Aug 13;3(8):e2923
pubmed: 18698430
J Virol Methods. 2010 Sep;168(1-2):72-7
pubmed: 20435070
AMB Express. 2020 May 27;10(1):98
pubmed: 32462233
Emerg Infect Dis. 2017 Dec;23(12):2118-2119
pubmed: 28980894
BMC Evol Biol. 2007 Nov 08;7:214
pubmed: 17996036
Emerg Infect Dis. 2012 Sep;18(9):1446-52
pubmed: 22932129
Vet Sci. 2018 Feb 24;5(1):
pubmed: 29495276
Emerg Microbes Infect. 2020 Dec;9(1):886-888
pubmed: 32312185
J Virol. 2007 May;81(10):5181-91
pubmed: 17344280
Nat Commun. 2014;5:3142
pubmed: 24457975
Infect Genet Evol. 2020 Mar;78:104074
pubmed: 31634645
Methods Mol Biol. 2008;436:53-66
pubmed: 18370041
Emerg Microbes Infect. 2019;8(1):650-661
pubmed: 31014196
Avian Pathol. 2019 Oct;48(5):470-476
pubmed: 31142135