Examining Associations Between Dietary Inflammatory Index in Pregnancy, Pro-inflammatory Cytokine and Chemokine Levels at Birth, and Offspring Asthma and/or Wheeze by Age 4 Years.
Adult
Asthma
/ epidemiology
Chemokines
/ blood
Child, Preschool
Colorado
/ epidemiology
Cytokines
/ blood
Diet
/ adverse effects
Diet, Healthy
/ statistics & numerical data
Female
Fetal Blood
/ chemistry
Humans
Infant, Newborn
Longitudinal Studies
Male
Pregnancy
Prenatal Exposure Delayed Effects
/ epidemiology
Prenatal Nutritional Physiological Phenomena
Prospective Studies
Respiratory Sounds
/ etiology
Asthma
Cytokines
Dietary inflammatory index
Journal
Journal of the Academy of Nutrition and Dietetics
ISSN: 2212-2672
Titre abrégé: J Acad Nutr Diet
Pays: United States
ID NLM: 101573920
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
01
07
2020
revised:
14
02
2021
accepted:
16
02
2021
pubmed:
22
3
2021
medline:
25
11
2021
entrez:
21
3
2021
Statut:
ppublish
Résumé
Few studies have demonstrated associations between maternal dietary inflammatory index (DII) during pregnancy and offspring asthma and/or wheeze. The study aimed to assess associations between maternal DII during pregnancy and 1) offspring cord sera pro-inflammatory cytokines (interleukin [IL]-1β, IL-4, IL-6, IL-10, tumor necrosis factor-α) and chemokines (IL-8, monocyte chemoattractant protein-1) at birth and 2) offspring asthma and/or wheeze at age 4 years. The Healthy Start study is a prospective prebirth longitudinal study that recruited pregnant women in Denver, Colorado and tracked their offspring. This study used data from 1228 mother-child dyads enrolled in the Healthy Start study. Pregnant women were recruited in Denver, Colorado, between 2009 and 2014, and offspring tracked until age 4 years. Cord sera cytokines and chemokines were analyzed with multiplex panel immunoassays. Offspring diagnosis of asthma and/or wheeze by age 4 years was extracted from electronic medical records. Unadjusted and adjusted linear and logistic regression models were used to assess associations. Covariates included factors such as nulliparity, race/ethnicity, gestational smoking, and maternal history of asthma. Unadjusted analysis showed that increasing maternal DII scores were associated with increased odds of child asthma and/or wheeze by 4 years (odds ratio = 1.17; 95% CI: 1.07-1.27), but the association was attenuated and no longer statistically significant in the adjusted model (odds ratio = 1.15; 95% CI: 0.99-1.33). There were no significant associations between DII scores and cord sera cytokine or chemokine levels. The study showed that the inflammatory profile of the maternal diet was not associated with cytokines and chemokine levels at birth. The results suggested that a more inflammatory maternal diet was associated with increased odds of offspring asthma and/or wheeze by age 4 years, which could be considered of clinical relevance but the finding was not statistically significant at the .05 level.
Sections du résumé
BACKGROUND
Few studies have demonstrated associations between maternal dietary inflammatory index (DII) during pregnancy and offspring asthma and/or wheeze.
OBJECTIVE
The study aimed to assess associations between maternal DII during pregnancy and 1) offspring cord sera pro-inflammatory cytokines (interleukin [IL]-1β, IL-4, IL-6, IL-10, tumor necrosis factor-α) and chemokines (IL-8, monocyte chemoattractant protein-1) at birth and 2) offspring asthma and/or wheeze at age 4 years.
DESIGN
The Healthy Start study is a prospective prebirth longitudinal study that recruited pregnant women in Denver, Colorado and tracked their offspring.
PARTICIPANTS AND SETTING
This study used data from 1228 mother-child dyads enrolled in the Healthy Start study. Pregnant women were recruited in Denver, Colorado, between 2009 and 2014, and offspring tracked until age 4 years.
MAIN OUTCOME MEASURES
Cord sera cytokines and chemokines were analyzed with multiplex panel immunoassays. Offspring diagnosis of asthma and/or wheeze by age 4 years was extracted from electronic medical records.
STATISTICAL ANALYSES PERFORMED
Unadjusted and adjusted linear and logistic regression models were used to assess associations. Covariates included factors such as nulliparity, race/ethnicity, gestational smoking, and maternal history of asthma.
RESULTS
Unadjusted analysis showed that increasing maternal DII scores were associated with increased odds of child asthma and/or wheeze by 4 years (odds ratio = 1.17; 95% CI: 1.07-1.27), but the association was attenuated and no longer statistically significant in the adjusted model (odds ratio = 1.15; 95% CI: 0.99-1.33). There were no significant associations between DII scores and cord sera cytokine or chemokine levels.
CONCLUSIONS
The study showed that the inflammatory profile of the maternal diet was not associated with cytokines and chemokine levels at birth. The results suggested that a more inflammatory maternal diet was associated with increased odds of offspring asthma and/or wheeze by age 4 years, which could be considered of clinical relevance but the finding was not statistically significant at the .05 level.
Identifiants
pubmed: 33744233
pii: S2212-2672(21)00135-0
doi: 10.1016/j.jand.2021.02.015
pmc: PMC8446107
mid: NIHMS1675898
pii:
doi:
Substances chimiques
Chemokines
0
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2003-2012.e3Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK076648
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023248
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM111901
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES025817
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM121081
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023248
Pays : United States
Informations de copyright
Copyright © 2021 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.
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