Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications.
biopharmacy
burns
dihydroquercetin
polymorphism
regenerative medicine
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
20
07
2020
pubmed:
14
3
2021
medline:
5
11
2021
entrez:
13
3
2021
Statut:
ppublish
Résumé
Wound-healing activity of the crystalline form of dihydroquercetin and its microtubular pseudopolymorphic modification obtained by crystal engineering was compared using the rat model of IIIA degree burn. The rate of wound healing in the group treated with microtubular pseudopolymorphic modification of dihydroquercetin was 4.8±0.1%, which was higher by 11.6% than in the group treated with crystalline form (4.3±0.1%). Bioavailability analysis on MDCK cell culture showed that the apparent permeability coefficient of microtubular pseudopolymorphic modification was higher than that of crystalline form by 31.1% (19.4±0.2×10
Identifiants
pubmed: 33713223
doi: 10.1007/s10517-021-05083-w
pii: 10.1007/s10517-021-05083-w
pmc: PMC7955205
doi:
Substances chimiques
Quercetin
9IKM0I5T1E
taxifolin
9SOB9E3987
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
444-447Références
Biomed Khim. 2019 Feb;65(2):152-158
pubmed: 30950819
Med Sci Monit Basic Res. 2014 Apr 03;20:36-46
pubmed: 24694757
Int J Toxicol. 2015 Mar-Apr;34(2):162-81
pubmed: 25850419
Int J Pharm. 2009 Jul 30;377(1-2):148-52
pubmed: 19426789
Molecules. 2016 Sep 13;21(9):
pubmed: 27649117
Int J Mol Sci. 2020 May 21;21(10):
pubmed: 32455534
J Biomed Mater Res B Appl Biomater. 2020 Feb;108(2):555-567
pubmed: 31081996
Heliyon. 2019 Jul 13;5(7):e02047
pubmed: 31338467
Bull Exp Biol Med. 2017 May;163(1):57-60
pubmed: 28577102
Vestn Khir Im I I Grek. 2007;166(1):102-5
pubmed: 17672120