Distinct and Common Large-Scale Networks of the Hippocampal Long Axis in Older Age: Links to Episodic Memory and Dopamine D2 Receptor Availability.
Aged
Aging
/ metabolism
Dopamine Antagonists
Female
Functional Neuroimaging
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Memory, Episodic
Middle Aged
Neural Pathways
/ metabolism
Positron Emission Tomography Computed Tomography
Raclopride
Receptors, Dopamine D2
/ metabolism
PET
aging
dopamine
hippocampal axis
resting-state connectivity
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
10 06 2021
10 06 2021
Historique:
received:
13
07
2020
revised:
22
01
2021
accepted:
22
01
2021
pubmed:
7
3
2021
medline:
1
3
2022
entrez:
6
3
2021
Statut:
ppublish
Résumé
The hippocampal longitudinal axis has been linked to dissociated functional networks relevant to episodic memory. However, the organization of axis-dependent networks and their relation to episodic memory in aging remains less explored. Moreover, age-related deterioration of the dopamine (DA) system, affecting memory and functional network properties, might constitute a source of reduced specificity of hippocampal networks in aging. Here, we characterized axis-dependent large-scale hippocampal resting-state networks, their relevance to episodic memory, and links to DA in older individuals (n = 170, 64-68 years). Partial least squares identified 2 dissociated networks differentially connected to the anterior and posterior hippocampus. These overlapped with anterior-temporal/posterior-medial networks in young adults, indicating preserved organization of axis-dependent connectivity in old age. However, axis-specific networks were overall unrelated to memory and hippocampal DA D2 receptor availability (D2DR) measured with [11C]-raclopride positron emission tomography. Further analyses identified a memory-related network modulated by hippocampal D2DR, equally connected to anterior-posterior regions. This network included medial frontal, posterior parietal, and striatal areas. The results add to the current understanding of large-scale hippocampal connectivity in aging, demonstrating axis-dependent connectivity with dissociated anterior and posterior networks, as well as a primary role in episodic memory of connectivity shared by regions along the hippocampalaxis.
Identifiants
pubmed: 33676372
pii: 6155985
doi: 10.1093/cercor/bhab023
pmc: PMC8196260
doi:
Substances chimiques
DRD2 protein, human
0
Dopamine Antagonists
0
Receptors, Dopamine D2
0
Raclopride
430K3SOZ7G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3435-3450Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
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