Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths.
Acetylcholine
/ biosynthesis
Animals
Biomarkers
Cytokines
/ metabolism
Gene Expression
Helminthiasis
/ immunology
Helminths
/ immunology
Host-Parasite Interactions
/ immunology
Immunity, Innate
Immunity, Mucosal
Immunohistochemistry
Immunophenotyping
Lymphocyte Subsets
/ immunology
Nuclear Receptor Subfamily 1, Group F, Member 1
/ metabolism
Organ Specificity
/ immunology
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
05 03 2021
05 03 2021
Historique:
received:
27
05
2020
accepted:
11
12
2020
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
19
2
2022
Statut:
ppublish
Résumé
Innate lymphoid cells (ILCs) are critical mediators of immunological and physiological responses at mucosal barrier sites. Whereas neurotransmitters can stimulate ILCs, the synthesis of small-molecule neurotransmitters by these cells has only recently been appreciated. Group 2 ILCs (ILC2s) are shown here to synthesize and release acetylcholine (ACh) during parasitic nematode infection. The cholinergic phenotype of pulmonary ILC2s was associated with their activation state, could be induced by in vivo exposure to extracts of
Identifiants
pubmed: 33674321
pii: 6/57/eabd0359
doi: 10.1126/sciimmunol.abd0359
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Nuclear Receptor Subfamily 1, Group F, Member 1
0
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R015856/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203135/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J500379/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.