γδ T Lymphocytes in Asthma: a Complicated Picture.
Asthma
γδ T lymphocytes
γδ T subsets
Journal
Archivum immunologiae et therapiae experimentalis
ISSN: 1661-4917
Titre abrégé: Arch Immunol Ther Exp (Warsz)
Pays: Switzerland
ID NLM: 0114365
Informations de publication
Date de publication:
04 Mar 2021
04 Mar 2021
Historique:
received:
12
05
2020
accepted:
17
02
2021
entrez:
4
3
2021
pubmed:
5
3
2021
medline:
23
3
2021
Statut:
epublish
Résumé
A minor subset (approximately 5%) of peripheral T cells has their TCR build up from γ and δ chains instead of α and β-those are the γδ T lymphocytes. They can be functionally divided into subsets, e.g., Th1-, Th2-, Th9-, Th17-, Tfh-, and Treg-like γδ T cells. They share some specifics of both innate and adaptive immunity, and are capable of rapid response to a range of stimuli, including some viral and bacterial infections. Atopic diseases, including asthma, are one of major health-related problems of modern western societies. Asthma is one of the most common airway diseases, affecting people of all ages and having potential life-threatening consequences. In this paper, we review the current knowledge about the involvement of γδ T cells in the pathogenesis of asthma and its exacerbations. We summarize both the studies performed on human subjects as well as on the murine model of asthma. γδ T cells seem to be involved in the pathogenesis of asthma, different subsets probably perform opposite functions, e.g., symptom-exacerbating Vγ1 and symptom-suppressing Vγ4 in mice model of asthma.
Identifiants
pubmed: 33661375
doi: 10.1007/s00005-021-00608-7
pii: 10.1007/s00005-021-00608-7
pmc: PMC7932949
doi:
Substances chimiques
Interleukin-17
0
Receptors, Antigen, T-Cell, gamma-delta
0
Immunoglobulin E
37341-29-0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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