Airborne occupational exposures and the risk of developing respiratory symptoms and airway obstruction in the Lifelines Cohort Study.
COPD epidemiology
occupational lung disease
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
02 Mar 2021
02 Mar 2021
Historique:
received:
08
12
2020
revised:
27
01
2021
accepted:
05
02
2021
entrez:
3
3
2021
pubmed:
4
3
2021
medline:
4
3
2021
Statut:
aheadofprint
Résumé
To date, only a few studies have investigated the associations between occupational exposures and respiratory outcomes longitudinally in the general population. We investigated the associations between occupational exposures and the development of respiratory symptoms and airway obstruction in the Lifelines Cohort Study. We included 35 739 occupationally active subjects with data on chronic cough, chronic phlegm, chronic bronchitis or airway obstruction at baseline and approximately 4.5 years follow-up. Exposures to biological dust, mineral dust, gases/fumes, pesticides, solvents and metals in the current job at baseline were estimated with the ALOHA+job-exposure matrix (JEM). Airway obstruction was defined as FEV At follow-up, 1888 (6.0%), 1495 (4.7%), 710 (2.5%) and 508 (4.5%) subjects had developed chronic cough, chronic phlegm, chronic bronchitis and airway obstruction, respectively. High exposure to biological dust was associated with a higher odds to develop chronic cough and chronic bronchitis. High exposure to pesticides was associated with a higher odds for the development of all respiratory symptoms and airway obstruction. In the multiple exposures analyses, only the association between pesticides exposure and respiratory symptoms remained. Subjects exposed to high pesticides had a higher odds to develop respiratory symptoms on average 4.5 years later. Control measures should be taken to reduce pesticides exposure among the working population to prevent respiratory symptoms and airway obstruction.
Identifiants
pubmed: 33653936
pii: thoraxjnl-2020-216721
doi: 10.1136/thoraxjnl-2020-216721
pmc: PMC8311115
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Lancet Respir Med. 2020 Jun;8(6):585-596
pubmed: 32526187
Toxicol Mech Methods. 2015;25(4):258-78
pubmed: 25757504
Occup Environ Med. 2019 Feb;76(2):105-113
pubmed: 30598459
Chest. 2012 Jun;141(6):1522-1527
pubmed: 22116794
Eur Respir J. 2017 Nov 22;50(5):
pubmed: 29167298
PLoS One. 2015 Sep 02;10(9):e0137203
pubmed: 26333164
Occup Environ Med. 1998 Oct;55(10):651-6
pubmed: 9930084
Am J Respir Crit Care Med. 1998 Feb;157(2):512-7
pubmed: 9476866
J Leukoc Biol. 2001 Sep;70(3):367-73
pubmed: 11527985
Thorax. 2018 Nov;73(11):1008-1015
pubmed: 29574416
Am J Respir Crit Care Med. 2012 Jun 15;185(12):1292-300
pubmed: 22492989
Occup Environ Med. 2019 Apr;76(4):222-229
pubmed: 30700596
Am J Epidemiol. 2002 Oct 15;156(8):738-46
pubmed: 12370162
Eur Respir Rev. 2014 Jun;23(132):180-92
pubmed: 24881073
Thorax. 2009 Oct;64(10):894-900
pubmed: 19581277
Am J Respir Crit Care Med. 2002 Oct 1;166(7):933-8
pubmed: 12359649
Am J Respir Crit Care Med. 2008 Feb 1;177(3):253-60
pubmed: 18006882
Respir Res. 2005 Aug 25;6:98
pubmed: 16120227
Ann Occup Hyg. 1993 Jun;37(3):253-70
pubmed: 8346874
Int J Mol Med. 2016 Oct;38(4):1012-20
pubmed: 27600395
Am J Epidemiol. 2014 Jun 1;179(11):1323-30
pubmed: 24780843
Thorax. 2017 Jun;72(6):498-499
pubmed: 27879416
Eur Respir J. 2005 Aug;26(2):319-38
pubmed: 16055882
Scand J Work Environ Health. 1992 Apr;18(2):105-12
pubmed: 1604270
Occup Environ Med. 2014 Feb;71(2):88-96
pubmed: 24142985
Pneumologie. 2002 May;56(5):297-303
pubmed: 12089647
Chest. 2006 Aug;130(2):318-25
pubmed: 16899828
J Occup Health. 2009;51(6):488-97
pubmed: 19851039
Am J Respir Crit Care Med. 2004 Oct 1;170(7):773-9
pubmed: 15229097
Occup Environ Med. 2021 Feb;78(2):82-85
pubmed: 32769140
Am J Respir Crit Care Med. 2005 Nov 1;172(9):1139-45
pubmed: 16040784
Int J Epidemiol. 2015 Aug;44(4):1172-80
pubmed: 25502107