Prevalence and incidence of epilepsy in Latin America and the Caribbean: A systematic review and meta-analysis of population-based studies.
Latin America
epilepsy
incidence
meta-analysis
prevalence
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
28
01
2021
received:
19
10
2020
accepted:
30
01
2021
pubmed:
3
3
2021
medline:
22
9
2021
entrez:
2
3
2021
Statut:
ppublish
Résumé
This study was undertaken to perform an updated systematic review and meta-analysis to estimate the pooled prevalence and incidence of epilepsy in Latin America and the Caribbean (LAC), describing trends over time, and exploring potential clinical and epidemiological factors explaining the heterogeneity in the region. Observational studies assessing the incidence or prevalence of epilepsy in LAC countries up to March 2020 were systematically reviewed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Meta-analyses and cumulative analyses were performed using random-effects models. We assessed between-study heterogeneity with sensitivity, subgroup, and meta-regression analyses. Moreover, the quality of the included studies and the certainty of evidence were evaluated using the GRADE (grading of recommendation, assessment, development, and evaluation) approach. Overall, 40 studies (from 42 records) were included, 37 for prevalence analyses and six for incidence (312 387 inhabitants; 410 178 person-years). The lifetime prevalence was 14.09 per 1000 inhabitants (95% confidence interval [CI] = 11.72-16.67), for active epilepsy prevalence was 9.06 per 1000 individuals (95% CI = 6.94-11.44), and the incidence rate was 1.11 per 1000 person-years (95% CI = .65-1.70). These high estimates have been constant in the region since 1990. However, substantial statistical heterogeneity between studies and publication bias were found. The overall certainty of evidence was low. Methodological aspects (sample size) and countries' epidemiological characteristics such as access to sanitation services and child and adult mortality rates explained the high heterogeneity. Finally, the prevalence of epilepsy associated with neurocysticercosis (NCC) in the general population was high, and the proportion of NCC diagnosis among people living with epilepsy was 17.37%. The epilepsy prevalence and incidence in LAC are higher than worldwide estimates, being constant since 1990 and strongly influenced by NCC. We identified high between-study heterogeneity and significant methodological limitations (e.g., heterogeneous definitions, lack of longitudinal studies). The region needs upgraded research using standardized definitions and diagnostic methods, and urgent action against preventable causes.
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
984-996Informations de copyright
© 2021 International League Against Epilepsy.
Références
Fiest KM, Birbeck GL, Jacoby A, Jette N. Stigma in epilepsy. Curr Neurol Neurosci Rep. 2014;14:444.
Begley CE, Beghi E. The economic cost of epilepsy: a review of the literature. Epilepsia. 2002;43:3-9.
Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon C-S, Dykeman J, et al. Prevalence and incidence of epilepsy: a systematic review and meta-analysis of international studies. Neurology. 2017;88:296-303.
Bruno E, Bartoloni A, Zammarchi L, Strohmeyer M, Bartalesi F, Bustos JA, et al. Epilepsy and neurocysticercosis in Latin America: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2013;7:e2480.
Burneo JG, Tellez-Zenteno J, Wiebe S. Understanding the burden of epilepsy in Latin America: a systematic review of its prevalence and incidence. Epilepsy Res. 2005;66:63-74.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;21(6):e1000100.
Garcia-Martin G, Serrano-Castro PJ. Epidemiology of epilepsy in Spain and Latin America. Rev Neurol. 2018;1(67):249-62.
Fantom N, Serajuddin U. The World Bank's Classification of Countries by Income. Policy Research Working Paper;No. 7528. World Bank, Washington, DC. © World Bank. 2016. https://openknowledge.worldbank.org/handle/10986/23628. Accessed July 28, 2020.
List of member states by WHO region and mortality stratum. In: World health report 2003. Copenhagen, Denmark: World Health Organization; 2003. p. 182.
McGillivray M, White H. Measuring development? The UNDP's human development index. J Int Dev. 1993;5:183-92.
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55:475-82.
Freeman MF, Tukey JW. Transformations related to the angular and the square root. Ann Math Stat. 1950;607-11.
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-88.
Barendregt JJ, Doi SA, Lee YY, Norman RE, Vos T. Meta-analysis of prevalence. J Epidemiol Commun Health. 2013;67:974.
Guerin JM, Copersino ML, Schretlen DJ. Clinical utility of the 15-item Geriatric Depression Scale (GDS-15) for use with young and middle-aged adults. J Affect Disord. 2018;1(241):59-62.
Harbord RM, Higgins JPT. Meta-regression in Stata. Stata J. 2008;8:493-519.
Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted? Stat Med. 2002;15(21):1559-73.
Saracino RM, Weinberger MI, Roth AJ, Hurria A, Nelson CJ. Assessing depression in a geriatric cancer population. Psychooncology. 2017;26:1484-90.
Loney PL, Chambers LW, Bennett KJ, Roberts JG, Stratford PW. Critical appraisal of the health research literature: prevalence or incidence of a health problem. Chronic Dis Can. 1998;19:170-6.
Balshem H, Helfand M, Schünemann HJ, Oxman AD, Kunz R, Brozek J, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64:401-6.
Schunemann H. GRADE handbook for grading quality of evidence and strength of recommendation. Version 3.2. 2008. https://gdt.gradepro.org/app/handbook/handbook.html. Accessed October 18, 2020.
Abib CR, Mendoza-Sassi RA, Bech-Nappi J, Stein AT. Prevalence of seizures and associated factors in children under five living in a deprived municipality of southern Brazil. Arq Neuropsiquiatr. 2007;65:581-6.
Arruda WO, Camargo NJ, Coelho RC. Neurocysticercosis: an epidemiological survey in two small rural communities. Arq Neuropsiquiatria. 1990;48:419-24.
Basch EM, Cruz ME, Tapia D, Cruz A. Prevalence of epilepsy in a migrant population near Quito, Ecuador. Neuroepidemiology. 1997;16:94-8.
Borges MA, Min LL, Guerreiro CAM, Yacubian EMT, Cordeiro JA, Tognola WA, et al. Urban prevalence of epilepsy: populational study in São José do Rio Preto, a medium-sized city in Brazil. Arq Neuropsiquiatria. 2004;62:199-205.
Bruno E, Quattrocchi G, Crespo Gómes EB, Sofia V, Padilla S, Camargo M, et al. Prevalence and incidence of epilepsy associated with convulsive seizures in rural Bolivia. A Global Campaign Against Epilepsy Project. PLoS One. 2015;10:e0139108.
Caraveo Anduaga J, Medina Mora ME, Rascón ML, Villatoro J, Martínez Vélez A, Gómez M. La prevalencia de los trastornos psiquiátricos en la población urbana adulta en México. Salud Ment (Mexico City). 1996;19:14-21.
Cruz Alcalá LE, Vázquez Castellanos JL. Prevalencia de algunas enfermedades neurológicas en la Ciudad de Tepatitlán. Revista Mexicana de Neurociencia. 2002;3(2):71-6.
Cruz ME, Schantz PM, Cruz I, Espinosa P, Preux PM, Cruz A, et al. Epilepsy and neurocysticercosis in an Andean community. Int J Epidemiol. 1999;28:799-803.
Cruz ME, Schoenberg BS, Ruales J, Barberis P, Proano J, Bossano F, et al. Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. Neuroepidemiology. 1985;4:108-16.
Del Brutto OH, Arroyo G, Del Brutto VJ, Zambrano M, Garcia HH. On the relationship between calcified neurocysticercosis and epilepsy in an endemic village: a large-scale, computed tomography-based population study in rural Ecuador. Epilepsia. 2017;58:1955-61.
Del Brutto OH, Santibáñez R, Idrovo L, Rodrìguez S, Díaz-Calderón E, Navas C, et al. Epilepsy and neurocysticercosis in Atahualpa: a door-to-door survey in rural coastal Ecuador. Epilepsia. 2005;46:583-7.
Diaz-Cabezas R, Ruano-Restrepo MI, Chacon-Cardona JA, Vera-Gonzalez A. Neuroepidemiology profile of the central zone of the department of Caldas (Colombia), years 2004-2005. Rev Neurol. 2006;43:646-52.
Garcia Pedroza F, Rubio Donnadieu F, Garcia RG. Prevalence of epilepsy in children: Tlalpan, Mexico City, Mexico. Neuroepidemiology. 1983;2:16-23.
Garcia-Noval J, Moreno E, de Mata F, Soto de Alfaro H, Fletes C, Craig PS, et al. An epidemiological study of epilepsy and epileptic seizures in two rural Guatemalan communities. Ann Trop Med Parasitol. 2001;95:167-75.
Garófalo Gómez N, Gómez García AM, Fernández Concepción O, Camfield P, Camfield C. Prevalencia y gravedad de la epilepsia pediátrica en Cuba. Salud(i)ciencia (Impresa). 2012;19:456.
Gomes MDM, Zeitoune RG, Kropf LAL, Beeck EdSV. A house-to-house survey of epileptic seizures in an urban community of Rio de Janeiro, Brazil. Arq Neuropsiquiatria. 2002;60:708-11.
Gonzales I, Miranda JJ, Rodriguez S, Vargas V, Cjuno A, Smeeth L, et al. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. Trop Med Int Health. 2015;20:546-52.
Gutiérrez JH. Prevalencia de epilepsia infantil en una población rural de México. Salud Publica Mex. 2014;22:269-73.
Ketzoian C. Estudio piloto de la prevalencia de las principales enfermedades neurológicas en el Uruguay. Rev Neurol Argent. 1994;19:21-31.
Lavados J, Germain L, Morales A, Campero M, Lavados P. A descriptive study of epilepsy in the district of El Salvador, Chile, 1984-1988. Acta Neurol Scand. 1992;85:249-56.
Marino Júnior R, Cukiert A, Pinho E. Epidemiological aspects of epilepsy in Sao Paulo: a prevalence study. Arq Neuropsiquiatr. 1986;44:243-54.
Medina MT, Aguilar-Estrada RL, Alvarez A, Duron RM, Martinez L, Dubon S, et al. Reduction in rate of epilepsy from neurocysticercosis by community interventions: the Salamá, Honduras study. Epilepsia. 2011;52:1177-85.
Medina MT, Durón R, Ramírez F, Aguilar R, Dubón S, Zelaya A, et al. Prevalencia de enfermedades neurológicas en Tegucigalpa: el estudio Kennedy. Rev Med Hondur. 2003;71:8-17.
Melcon MO, Kochen S, Vergara RH. Prevalence and clinical features of epilepsy in Argentina. A community-based study. Neuroepidemiology. 2007;28:8-15.
Mendizabal JE, Salguero LF. Prevalence of epilepsy in a rural community of Guatemala. Epilepsia. 1996;37:373-6.
Montano SM, Villaran MV, Ylquimiche L, Figueroa JJ, Rodriguez S, Bautista CT, et al. Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru. Neurology. 2005;26(65):229-33.
Moyano LM, Saito M, Montano SM, Gonzalvez G, Olaya S, Ayvar V, et al. Neurocysticercosis as a cause of epilepsy and seizures in two community-based studies in a cysticercosis-endemic region in Peru. PLoS Negl Trop Dis. 2014;8:e2692.
Nicoletti A, Reggio A, Bartoloni A, Failla G, Sofia V, Bartalesi F, et al. Prevalence of epilepsy in rural Bolivia: a door-to-door survey. Neurology. 1999;10(53):2064-9.
Nicoletti A, Bartoloni A, Sofia V, Bartalesi F, Chavez JR, Osinaga R, et al. Epilepsy and neurocysticercosis in rural bolivia: a population-based survey. Epilepsia. 2005;46:1127-32.
Noronha AL, Borges MA, Marques LH, Zanetta DM, Fernandes PT, de Boer H, et al. Prevalence and pattern of epilepsy treatment in different socioeconomic classes in Brazil. Epilepsia. 2007;48:880-5.
Nunes ML, Geib LT. Incidence of epilepsy and seizure disorders in childhood and association with social determinants: a birth cohort stud. J Pediatr. 2011;87:50-6.
Orlinder N, Varela FE, Durón R, Medina MT. Aspectos socio-culturales y antroplógicos que inciden en la determinación de la prevalencia de las epilepsias en la en la etnia misquita del departamento de Gracias a Dios, Honduras. Rev Med Hondur. 2002;70:9-14.
Paul TJ, Desai P, Thorburn MJ. The prevalence of childhood disability and related medical diagnosis in Clarendon, Jamaica. West Indian Med J. 1992;41:8-11.
Placencia M. Prevalencia de epilepsia en la Sierra Norte Ecuatoriana, un trabajo clínico-epidemiológico, 1984-1989. Metro Cienc. 1991;1:4-13.
Placencia M. Incidencia de crisis epilépticas en la Sierra Norte Ecuatoriana: un perfil epidemiológico, 1984-1989. Rev Ecuat Neurol. 1992;1:72-6.
Pradilla AG, Vesga ABE, León-Sarmiento FE, Roselli DA, Bautista LE, Morillo L, et al. Estudio Neuroepidemiológico Nacional (EPINEURO) Colombiano. Rev Panam Salud Publica. 2003;14:104-11.
Quet F, Preux PM, Huerta M, Ramirez R, Abad T, Fragoso G, et al. Determining the burden of neurological disorders in populations living in tropical areas: who would be questioned? Lessons from a Mexican rural community. Neuroepidemiology. 2011;36:194-203.
Sampaio LP, Caboclo LO, Kuramoto K, Reche A, Yacubian EM, Manreza ML. Prevalence of epilepsy in children from a Brazilian area of high deprivation. Pediatr Neurol. 2010;42:111-7.
Somoza MJ, Forlenza RH, Brussino M, Licciardi L. Epidemiological survey of epilepsy in the primary school population in Buenos Aires. Neuroepidemiology. 2005;25:62-8.
Velez A, Eslava-Cobos J. Epilepsy in Colombia: epidemiologic profile and classification of epileptic seizures and syndromes. Epilepsia. 2006;47:193-201.
Villaran MV, Montano SM, Gonzalvez G, Moyano LM, Chero JC, Rodriguez S, et al. Epilepsy and neurocysticercosis: an incidence study in a Peruvian rural population. Neuroepidemiology. 2009;33:25-31.
Zuloaga PL, Soto VC, Jaramillo VD, Mora LO, Betancur TC, Londono LR. Prevalencia de epilepsia en Medellin. Colombia, 1983. Bol Oficina Sanit Panam. 1988;104:331-44.
Placencia M, Sander JW, Shorvon SD, Ellison RH, Cascante SM. Validation of a screening questionnaire for the detection of epileptic seizures in epidemiological studies. Brain. 1992;115(Pt 3):783-94.
WHO protocol: Epidemiologic studies of neurologic disorders. 1982. https://apps.who.int/iris/bitstream/handle/10665/72410/a82497.pdf. Accessed October 18, 2020.
Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia. 2010;51:883-90.
Singh G, Angwafor SA, Njamnshi AK, Fraimow H, Sander JW. Zoonotic and vector-borne parasites and epilepsy in low-income and middle-income countries. Nat Rev Neurol. 2020;16:333-45.
Borges G, Monteiro M, Cherpitel CJ, Orozco R, Ye Y, Poznyak V, et al. Alcohol and road traffic injuries in Latin America and the Caribbean: a case-crossover study. Alcohol Clin Exp Res. 2017;41:1731-7.
Bronberg R, Gili J, Gimenez L, Dipierri J, Lopez CJ. Biosocial correlates and spatial distribution of consanguinity in South America. Am J Hum Biol. 2016;28:405-11.
GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1459-544.
Tejada CAO, Triaca LM, Liermann NH, Ewerling F, Costa JC. Economic crises, child mortality and the protective role of public health expenditure. Cien Saude Colet. 2019;24:4395-404.
Cohen RL, Murray J, Jack S, Arscott-Mills S, Verardi V. Impact of multisectoral health determinants on child mortality 1980-2010: an analysis by country baseline mortality. PLoS One. 2017;12:e0188762.
Garcia HH, Gonzalez AE, Tsang VC, O'Neal SE, Llanos-Zavalaga F, Gonzalvez G, et al. Elimination of Taenia solium transmission in Northern Peru. N Engl J Med. 2016;16(374):2335-44.
Medina MT, Durón RM, Martínez L, Osorio JR, Estrada AL, Zúniga C, et al. Prevalence, incidence, and etiology of epilepsies in rural Honduras: the Salamá Study. Epilepsia. 2005;46:124-31.
de Coster T, Van Damme I, Baauw J, Gabriël S. Recent advancements in the control of Taenia solium: a systematic review. Food Waterborne Parasitol. 2018;13:e00030.
CystiTeam Group for Epidemiology and Modelling of Taenia solium Taeniasis/Cysticercosis. The World Health Organization 2030 goals for Taenia solium: insights and perspectives from transmission dynamics modelling: CystiTeam Group for Epidemiology and Modelling of Taenia solium Taeniasis/Cysticercosis. Gates Open Res. 2019;3:1546.