Unmasking the immune microecology of ductal carcinoma in situ with deep learning.
Journal
NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891
Informations de publication
Date de publication:
01 Mar 2021
01 Mar 2021
Historique:
received:
11
02
2020
accepted:
21
10
2020
entrez:
2
3
2021
pubmed:
3
3
2021
medline:
3
3
2021
Statut:
epublish
Résumé
Despite increasing evidence supporting the clinical relevance of tumour infiltrating lymphocytes (TILs) in invasive breast cancer, TIL spatial variability within ductal carcinoma in situ (DCIS) samples and its association with progression are not well understood. To characterise tissue spatial architecture and the microenvironment of DCIS, we designed and validated a new deep learning pipeline, UNMaSk. Following automated detection of individual DCIS ducts using a new method IM-Net, we applied spatial tessellation to create virtual boundaries for each duct. To study local TIL infiltration for each duct, DRDIN was developed for mapping the distribution of TILs. In a dataset comprising grade 2-3 pure DCIS and DCIS adjacent to invasive cancer (adjacent DCIS), we found that pure DCIS cases had more TILs compared to adjacent DCIS. However, the colocalisation of TILs with DCIS ducts was significantly lower in pure DCIS compared to adjacent DCIS, which may suggest a more inflamed tissue ecology local to DCIS ducts in adjacent DCIS cases. Our study demonstrates that technological developments in deep convolutional neural networks and digital pathology can enable an automated morphological and microenvironmental analysis of DCIS, providing a new way to study differential immune ecology for individual ducts and identify new markers of progression.
Identifiants
pubmed: 33649333
doi: 10.1038/s41523-020-00205-5
pii: 10.1038/s41523-020-00205-5
pmc: PMC7921670
doi:
Types de publication
Journal Article
Langues
eng
Pagination
19Subventions
Organisme : NCI NIH HHS
ID : U54 CA217376
Pays : United States
Organisme : NCI NIH HHS
ID : U2C CA233254
Pays : United States
Organisme : Cancer Research UK (CRUK)
ID : C45982/A21808
Organisme : NCI NIH HHS
ID : P01 CA091955
Pays : United States
Organisme : Breast Cancer Now
ID : 2015NovPR638
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA170595
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA214183
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA140657
Pays : United States
Organisme : Breast Cancer Now (BCN)
ID : 2015NovPR638
Organisme : NCI NIH HHS
ID : R01 CA185138
Pays : United States
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