Physiological responses to acute psychosocial stress in women with menopausal insomnia.
Cortisol
Hyperarousal
Insomnia
Menopause
Progesterone
Trier social stress task
Journal
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
ISSN: 1872-7697
Titre abrégé: Int J Psychophysiol
Pays: Netherlands
ID NLM: 8406214
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
10
09
2020
revised:
06
01
2021
accepted:
23
02
2021
pubmed:
2
3
2021
medline:
26
10
2021
entrez:
1
3
2021
Statut:
ppublish
Résumé
Insomnia disorder is a common sleep disorder and frequently emerges in the context of menopause, being associated with menopause-specific factors such as hot flashes and other psychosocial variables. Increased vulnerability to stress may also contribute to the development of insomnia in midlife women. Here, we aimed to investigate whether there are differences in physiological reactivity to acute psychosocial stress in women with menopausal insomnia compared with controls. We investigated cortisol and heart rate [HR] responses to an acute experimental psychosocial stress (Trier Social Stress Test, TSST) approximately 1 h after waking in the morning in midlife women with (n = 22) and without (n = 16) DSM-IV insomnia disorder (Age: 50.05 ± 3.10 years), developed in the context of menopause. Despite similar perceived stress levels, women with insomnia showed blunted HR increases (~29% HR acceleration) to the TSST compared to controls (~44% HR acceleration) (p = 0.026). No group differences in HR were detected at baseline or during post-task recovery. Cortisol stress responses were inconclusive, with most of the women (60%) failing to exhibit significant cortisol increases in response to the TSST. A greater magnitude of the cortisol awakening response (CAR) predicted the likelihood of being a non-responder (p = 0.036), showing the confounding effect of CAR on cortisol stress responses. Women with menopausal insomnia show blunted cardiac responses to stress, suggesting alterations in the autonomic reactivity to acute stress. Whether these alterations are pre-existing or are a consequence of insomnia, needs to be determined.
Identifiants
pubmed: 33647384
pii: S0167-8760(21)00077-5
doi: 10.1016/j.ijpsycho.2021.02.019
pmc: PMC8101364
mid: NIHMS1683186
pii:
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
87-94Subventions
Organisme : NICHD NIH HHS
ID : P50 HD028934
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL103688
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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