Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
16 Feb 2021
Historique:
pubmed: 24 2 2021
medline: 24 2 2021
entrez: 23 2 2021
Statut: epublish

Résumé

There is an urgent need to understand the nature of immune responses generated against SARS-CoV-2, to better inform risk-mitigation strategies for people living with HIV (PLWH). Although not all PLWH are considered immunosuppressed, residual cellular immune deficiency and ongoing inflammation could influence COVID-19 disease severity, the evolution and durability of protective memory responses. Here, we performed an integrated analysis, characterizing the nature, breadth and magnitude of SARS-CoV-2-specific immune responses in PLWH, controlled on ART, and HIV negative subjects. Both groups were in the convalescent phase of predominately mild COVID-19 disease. The majority of PLWH mounted SARS-CoV-2 Spike- and Nucleoprotein-specific antibodies with neutralizing activity and SARS-CoV-2-specific T cell responses, as measured by ELISpot, at levels comparable to HIV negative subjects. T cell responses against Spike, Membrane and Nucleocapsid were the most prominent, with SARS-CoV-2-specific CD4 T cells outnumbering CD8 T cells. Notably, the overall magnitude of SARS-CoV-2-specific T cell responses related to the size of the naive CD4 T cell pool and the CD4:CD8 ratio in PLWH, in whom disparate antibody and T cell responses were observed. Both humoral and cellular responses to SARS-CoV-2 were detected at 5-7 months post-infection, providing evidence of medium-term durability of responses irrespective of HIV serostatus. Incomplete immune reconstitution on ART and a low CD4:CD8 ratio could, however, hamper the development of immunity to SARS-CoV-2 and serve as a useful tool for risk stratification of PLWH. These findings have implications for the individual management and potential effectiveness of vaccination against SARS-CoV-2 in PLWH.

Identifiants

pubmed: 33619489
doi: 10.1101/2021.02.15.431215
pmc: PMC7899453
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : Medical Research Council
ID : MR/L018942/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008614/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R008698/1
Pays : United Kingdom

Commentaires et corrections

Type : UpdateIn

Déclaration de conflit d'intérêts

Competing interests: The authors have declared that no conflict of interest exists.

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Auteurs

Aljawharah Alrubayyi (A)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.

Ester Gea-Mallorquí (E)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.

Emma Touizer (E)

Division of Infection and Immunity, University College London, London, United Kingdom.

Dan Hameiri-Bowen (D)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.

Jakub Kopycinski (J)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.

Bethany Charlton (B)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.

Natasha Fisher-Pearson (N)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.

Luke Muir (L)

Division of Infection and Immunity, University College London, London, United Kingdom.

Annachiara Rosa (A)

Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.

Chloe Roustan (C)

Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.

Christopher Earl (C)

Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.

Peter Cherepanov (P)

Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.

Pierre Pellegrino (P)

Mortimer Market Centre, Department of HIV, CNWL NHS Trust, London, United Kingdom.

Laura Waters (L)

Mortimer Market Centre, Department of HIV, CNWL NHS Trust, London, United Kingdom.

Fiona Burns (F)

Institute for Global Health UCL, London, United Kingdom.
Royal Free London NHS Foundation Trust, London, United Kingdom.

Sabine Kinloch (S)

Royal Free London NHS Foundation Trust, London, United Kingdom.

Tao Dong (T)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.

Lucy Dorrell (L)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.

Sarah Rowland-Jones (S)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.

Laura E McCoy (LE)

Division of Infection and Immunity, University College London, London, United Kingdom.

Dimitra Peppa (D)

Nuffield Dept of Clinical Medicine, University of Oxford, United Kingdom.
Mortimer Market Centre, Department of HIV, CNWL NHS Trust, London, United Kingdom.

Classifications MeSH