Treatment tolerability and outcomes in elderly patients with head and neck cancer.
elderly
geriatric
head and neck cancer
squamous cell carcinoma
treatment tolerability
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
02
05
2020
revised:
03
11
2020
accepted:
09
11
2020
pubmed:
23
2
2021
medline:
1
7
2021
entrez:
22
2
2021
Statut:
ppublish
Résumé
The number of elderly patients with head and neck squamous cell carcinoma (HNSCC) continues to grow. Management of this cohort remains poorly defined. We investigated treatment tolerability and clinical outcomes in this underrepresented population. We identified patients aged ≥70 with nonrecurrent, nonmetastatic HNSCC treated curatively from 2007-2018 and analyzed clinical covariates. Two hundred and twenty patients with a median age of 75 (interquartile range:72-80) were identified. Age and comorbidities were not correlated with toxicity (P ≥ .05). Patients who experienced a treatment interruption had significantly greater weight loss (P = .042) and worse overall survival (OS) (P < .001), but not worse disease-specific survival (P = .45), or locoregional control (P = .21). Treatment interruptions were associated with weight loss and worse OS, but not disease related outcomes, suggesting an interruption in the elderly may be a surrogate for another issue. In sum, our data should guide clinical trial design to benefit this growing, neglected cohort.
Identifiants
pubmed: 33615611
doi: 10.1002/hed.26548
pmc: PMC9521799
mid: NIHMS1833023
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
858-873Subventions
Organisme : NIA NIH HHS
ID : P30 AG028741
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001434
Pays : United States
Organisme : Claude D. Older Americans Independent Pepper Center at the Icahn School of Medicine
ID : 5P30AG028741-07
Informations de copyright
© 2020 Wiley Periodicals LLC.
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