Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: a replication study.
high-frequency stimulation
homotopic hyperalgesia
long-term potentiation
Journal
Royal Society open science
ISSN: 2054-5703
Titre abrégé: R Soc Open Sci
Pays: England
ID NLM: 101647528
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
16
05
2020
accepted:
18
12
2020
entrez:
22
2
2021
pubmed:
23
2
2021
medline:
23
2
2021
Statut:
epublish
Résumé
Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibres induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can be observed in humans. In 20 healthy volunteers, we applied HFS to the left or right volar forearm. Before and after applying HFS, we delivered single electrical test stimuli through the HFS electrode while a second electrode at the contra-lateral arm served as a control condition. Moreover, to test the efficacy of the HFS protocol, we quantified changes in mechanical pinprick sensitivity before and after HFS of the skin surrounding both electrodes. The perceived intensity was collected for both electrical and mechanical stimuli. After HFS, the perceived pain intensity elicited by the mechanical pinprick stimuli applied on the skin surrounding the HFS-treated site was significantly higher compared to control site (heterotopic effect). Furthermore, we found a higher perceived pain intensity for single electrical stimuli delivered to the HFS-treated site compared to the control site (homotopic effect). Whether the homotopic effect reflects a perceptual correlate of homosynaptic LTP remains to be elucidated.
Identifiants
pubmed: 33614062
doi: 10.1098/rsos.200830
pii: rsos200830
pmc: PMC7890496
doi:
Banques de données
Dryad
['10.5061/dryad.p8cz8w9nh']
Types de publication
Journal Article
Langues
eng
Pagination
200830Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
We declare we have no competing interests.
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