Synthesis, characterization and pharmacological evaluation of quinoline derivatives and their complexes with copper(ΙΙ) in in vitro cell models of Alzheimer's disease.
Acetylcholinesterase
/ chemistry
Alzheimer Disease
/ drug therapy
Animals
CHO Cells
Catalytic Domain
Cell Line, Tumor
Coordination Complexes
/ chemical synthesis
Copper
/ chemistry
Cricetulus
Humans
Hydrogen Peroxide
/ toxicity
Ligands
Molecular Docking Simulation
Neuroprotective Agents
/ chemical synthesis
Protein Binding
Quinolines
/ chemical synthesis
Alzheimer's disease
Metal complex
Neuroprotection
Oxidative stress
Quinoline
SH-SY5Y
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
04
11
2020
revised:
30
01
2021
accepted:
05
02
2021
pubmed:
21
2
2021
medline:
11
1
2022
entrez:
20
2
2021
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system. The main pathophysiological mechanisms involve cholinergic neurotransmission, beta-amyloid (Αβ) and Tau proteins, several metal ions and oxidative stress, among others. Current drugs offer only relief of symptoms and not a cure of AD. Accumulating evidence suggests that multifunctional compounds, targeting multiple pathophysiological mechanisms, may have a great potential for the treatment of AD. In this study, we report on the synthesis and physicochemical characterization of four quinoline-based metal chelators and their respective copper(II) complexes. Most compounds were non-toxic at concentrations ≤5 μM. In neuroprotection studies employing undifferentiated and differentiated SH-SY5Y cells, the metal chelator N
Identifiants
pubmed: 33610031
pii: S0162-0134(21)00040-4
doi: 10.1016/j.jinorgbio.2021.111393
pii:
doi:
Substances chimiques
Coordination Complexes
0
Ligands
0
Neuroprotective Agents
0
Quinolines
0
Copper
789U1901C5
Hydrogen Peroxide
BBX060AN9V
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111393Informations de copyright
Copyright © 2021. Published by Elsevier Inc.