Rolled-Up Metal Oxide Microscaffolds to Study Early Bone Formation at Single Cell Resolution.

CaP formation and mineralization TiNb-oxide material biomaterial cell-material interaction single live cell analysis tubular microscaffold

Journal

Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338

Informations de publication

Date de publication:
03 2021
Historique:
revised: 11 01 2021
received: 06 09 2020
pubmed: 19 2 2021
medline: 15 7 2021
entrez: 18 2 2021
Statut: ppublish

Résumé

Titanium and its alloys are frequently used to replace structural components of the human body due to their high mechanical strength, low stiffness, and biocompatibility. In particular, the use of porous materials has improved implant stabilization and the promotion of bone. However, it remains unclear which material properties and geometrical cues are optimal for a proper osteoinduction and osseointegration. To that end, transparent tubular microscaffolds are fabricated, mimicking the typical pores of structural implants, with the aim of studying early bone formation and cell-material interactions at the single cell level. Here, a β-stabilized alloy Ti-45Nb (wt%) is used for the microscaffold's fabrication due to its elastic modulus close to that of natural bone. Human mesenchymal stem cell migration, adhesion, and osteogenic differentiation is thus investigated, paying particular attention to the CaP formation and cell-body crystallization, both analyzed via optical and electron microscopy. It is demonstrated that the developed platform is suited for the long-term study of living single cells in an appropriate microenvironment, obtaining in the process deeper insights on early bone formation and providing cues to improve the stability and biocompatibility of current structural implants.

Identifiants

pubmed: 33599055
doi: 10.1002/smll.202005527
doi:

Substances chimiques

Alloys 0
Biocompatible Materials 0
Oxides 0
Titanium D1JT611TNE

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2005527

Informations de copyright

© 2021 The Authors. Small published by Wiley-VCH GmbH.

Références

D. Arcos, A. R. Boccaccini, M. Bohner, A. Díez-Pérez, M. Epple, E. Gómez-Barrena, A. Herrera, J. A. Planell, L. Rodríguez-Mañas, M. Vallet-Regí, Acta Biomater. 2014, 10, 1793.
M. Niinomi, Y. Liu, M. Nakai, H. Liu, H. Li, Regen. Biomater. 2016, 3, 173.
T. Hanawa, Sci. Technol. Adv. Mater. 2012, 13, 064102.
M. Calin, A. Helth, J. J. Gutierrez Moreno, M. Bönisch, V. Brackmann, L. Giebeler, T. Gemming, C. E. Lekka, A. Gebert, R. Schnettler, J. Eckert, J. Mech. Behav. Biomed. Mater. 2014, 39, 162.
K. Alvarez, H. Nakajima, Materials 2009, 2, 790.
E. Babaie, S. B. Bhaduri, ACS Biomater. Sci. Eng. 2018, 4, 1.
N. Taniguchi, S. Fujibayashi, M. Takemoto, K. Sasaki, B. Otsuki, T. Nakamura, T. Matsushita, T. Kokubo, S. Matsuda, Mater. Sci. Eng. C 2016, 59, 690.
Z. Wang, C. Wang, C. Li, Y. Qin, L. Zhong, B. Chen, Z. Li, H. Liu, F. Chang, J. Wang, J. Alloys Compd. 2017, 717, 271.
X. Wang, S. Xu, S. Zhou, W. Xu, M. Leary, P. Choong, M. Qian, M. Brandt, Y. M. Xie, Biomaterials 2016, 83, 127.
Q. L. Loh, C. Choong, Tissue Eng. - Part B Rev. 2013, 19, 485.
G. Lutzweiler, A. N. Halili, N. E. Vrana, Pharmaceutics 2020, 12, 602.
A. I. Itälä, H. O. Ylänen, C. Ekholm, K. H. Karlsson, H. T. Aro, J. Biomed. Mater. Res. 2001, 58, 679.
M. Sadat-Shojai, M. T. Khorasani, E. Dinpanah-Khoshdargi, A. Jamshidi, Acta Biomater. 2013, 9, 7591.
M. Bohner, G. Baroud, A. Bernstein, N. Döbelin, L. Galea, B. Hesse, R. Heuberger, S. Meille, P. Michel, B. von Rechenberg, J. Sague, H. Seeherman, Mater. Today 2017, 20, 106.
S. M. Weiz, M. Medina-Sánchez, O. G. Schmidt, Adv. Biosyst. 2018, 2, 1700193.
C. W. Shields Iv, C. D. Reyes, G. P. López, Lab Chip 2015, 15, 1230.
J. Wan, Polymers 2012, 4, 1084.
N. T. Huang, H. L. Zhang, M. T. Chung, J. H. Seo, K. Kurabayashi, Lab Chip 2014, 14, 1230.
T. Sun, H. Morgan, Microfluid. Nanofluidics 2010, 8, 423.
F. Liu, P. Kc, G. Zhang, J. Zhe, PLoS One 2017, 12, e0172697.
E. J. Smith, S. Schulze, S. Kiravittaya, Y. Mei, S. Sanchez, O. G. Schmidt, Nano Lett. 2011, 11, 4037.
S. Schulze, G. Huang, M. Krause, D. Aubyn, V. A. B. Quiñones, C. K. Schmidt, Y. Mei, O. G. Schmidt, Adv. Eng. Mater. 2010, 12, B558.
B. Koch, A. K. Meyer, L. Helbig, S. M. Harazim, A. Storch, S. Sanchez, O. G. Schmidt, Nano Lett. 2015, 15, 5530.
W. Xi, C. K. Schmidt, S. Sanchez, D. H. Gracias, R. E. Carazo-Salas, S. P. Jackson, O. G. Schmidt, Nano Lett. 2014, 14, 4197.
B. Koch, S. Sanchez, C. K. Schmidt, A. Swiersy, S. P. Jackson, O. G. Schmidt, Adv. Healthcare Mater. 2014, 3, 1753.
S. J. P. Callens, R. J. C. Uyttendaele, L. E. Fratila-Apachitei, A. A. Zadpoor, Biomaterials 2020, 232, 119739.
K. A. Kilian, B. Bugarija, B. T. Lahn, M. Mrksich, Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 4872.
G. Chen, C. Dong, L. Yang, Y. Lv, ACS Appl. Mater. Interfaces 2015, 7, 15790.
A. J. Engler, S. Sen, H. L. Sweeney, D. E. Discher, Cell 2006, 126, 677.
S. Ehrig, B. Schamberger, C. M. Bidan, A. West, C. Jacobi, K. Lam, P. Kollmannsberger, A. Petersen, P. Tomancak, K. Kommareddy, F. D. Fischer, P. Fratzl, J. W. C. Dunlop, Sci. Adv. 2019, 5, eaav9394.
D. Baptista, L. Teixeira, C. van Blitterswijk, S. Giselbrecht, R. Truckenmüller, Trends Biotechnol. 2019, 37, 838.
O. G. Schmidt, K. Eberl, Nature 2001, 410, 168.
V. Y. Prinz, V. A. Seleznev, A. K. Gutakovsky, A. V. Chehovskiy, V. V. Preobrazhenskii, M. A. Putyato, T. A. Gavrilova, Phys. E 2000, 6, 828.
Y. F. Mei, G. S. Huang, A. A. Solovev, E. B. Urena, I. Moench, F. Ding, T. Reindl, R. K. Y. Fu, P. K. Chu, O. G. Schmidt, E. B. Ureña, I. Mönch, F. Ding, T. Reindl, R. K. Y. Fu, P. K. Chu, O. G. Schmidt, Adv. Mater. 2008, 20, 4085.
I. Jirka, M. Vandrovcová, O. Frank, Z. Tolde, J. Plšek, T. Luxbacher, L. Bačáková, V. Starý, Mater. Sci. Eng. C 2013, 33, 1636.
A. Helth, P. F. Gostin, S. Oswald, H. Wendrock, U. Wolff, U. Hempel, S. Arnhold, M. Calin, J. Eckert, A. Gebert, J. Biomed. Mater. Res. - Part B 2014, 102, 31.
S. Pilz, A. Gebert, A. Voss, S. Oswald, M. Göttlicher, U. Hempel, J. Eckert, M. Rohnke, J. Janek, M. Calin, J. Biomed. Mater. Res. - Part B 2018, 106, 1686.
A. Gebert, D. Eigel, P. F. Gostin, V. Hoffmann, M. Uhlemann, A. Helth, S. Pilz, R. Schmidt, M. Calin, M. Göttlicher, M. Rohnke, J. Janek, Surf. Coatings Technol. 2016, 302, 88.
W. Xi, C. K. Schmidt, S. Sanchez, D. H. Gracias, R. E. Carazo-Salas, R. Butler, N. Lawrence, S. P. Jackson, O. G. Schmidt, ACS Nano 2016, 10, 5835.
G. Huang, Y. Mei, D. J. Thurmer, E. Coric, O. G. Schmidt, Lab Chip 2009, 9, 263.
J. Ge, L. Guo, S. Wang, Y. Zhang, T. Cai, R. C. H. Zhao, Y. Wu, Stem Cell Rev. Rep. 2014, 10, 295.
C. P. Ng, A. R. Mohamed Sharif, D. E. Heath, J. W. Chow, C. B. Y. Zhang, M. B. Chan-Park, P. T. Hammond, J. K. Y. Chan, L. G. Griffith, Biomaterials 2014, 35, 4046.
W. Wagner, A. D. Ho, M. Zenke, Tissue Eng. - Part B Rev. 2010, 16, 445.
W. Wagner, P. Horn, M. Castoldi, A. Diehlmann, S. Bork, R. Saffrich, V. Benes, J. Blake, S. Pfister, V. Eckstein, A. D. Ho, PLoS One 2008, 3, e2213.
C. Elschner, C. Noack, C. Preißler, A. Krause, U. Scheler, U. Hempel, J. Mater. Sci. Technol. 2015, 31, 427.
M. N. Armenise, C. Canali, M. De Sario, A. Carnera, P. Mazzoldi, G. Celotti, J. Appl. Phys. 1983, 54, 6223.
S. Oswald, P.-F. Gostin, A. Helth, S. Abdi, L. Giebeler, H. Wendrock, M. Calin, J. Eckert, A. Gebert, Surf. Interface Anal. 2014, 46, 683.
M. T. Doolin, K. M. Stroka, Tissue Eng. - Part C 2019, 25, 662.
A. W. Holle, N. Govindan Kutty Devi, K. Clar, A. Fan, T. Saif, R. Kemkemer, J. P. Spatz, Nano Lett. 2019, 19, 2280.
M. Werner, A. Petersen, N. A. Kurniawan, C. V. C. Bouten, Adv. Biosyst. 2019, 3, 1900080.
M. Werner, S. B. G. Blanquer, S. P. Haimi, G. Korus, J. W. C. Dunlop, G. N. Duda, D. W. Grijpma, A. Petersen, Adv. Sci. 2017, 4, 1600347.
L. Pieuchot, J. Marteau, A. Guignandon, T. Dos Santos, I. Brigaud, P.-F. Chauvy, T. Cloatre, A. Ponche, T. Petithory, P. Rougerie, M. Vassaux, J.-L. Milan, N. Tusamda Wakhloo, A. Spangenberg, M. Bigerelle, K. Anselme, Nat. Commun. 2018, 9, 3995.
M. Zhu, E. Kohan, J. Bradley, M. Hedrick, P. Benhaim, P. Zuk, J. Tissue Eng. Regener. Med. 2009, 3, 290.
H. Hanna, L. M. Mir, F. M. Andre, Stem Cell Res. Ther. 2018, 9, 203.
D.-X. Wei, J.-W. Dao, G.-Q. Chen, Adv. Mater. 2018, 30, 1802273.
R. K. Jaiswal, N. Jaiswal, S. P. Bruder, G. Mbalaviele, D. R. Marshak, M. F. Pittenger, J. Cell. Physiol. 2000, 227, 1680.
C. M. Bidan, K. P. Kommareddy, M. Rumpler, P. Kollmannsberger, P. Fratzl, J. W. C. Dunlop, Adv. Healthcare Mater. 2013, 2, 186.
J. Foolen, T. Yamashita, P. Kollmannsberger, J. Phys. D. Appl. Phys. 2016, 49, 053001.
C. M. Bidan, K. P. Kommareddy, M. Rumpler, P. Kollmannsberger, Y. J. M. Bréchet, P. Fratzl, J. W. C. Dunlop, PLoS One 2012, 7, e36336.
N. D. Bade, R. D. Kamien, R. K. Assoian, K. J. Stebe, Sci. Adv. 2017, 3, e1700150.
T. Hasegawa, T. Yamamoto, E. Tsuchiya, H. Hongo, K. Tsuboi, A. Kudo, M. Abe, T. Yoshida, T. Nagai, N. Khadiza, A. Yokoyama, K. Oda, H. Ozawa, P. H. L. de Freitas, M. Li, N. Amizuka, Jpn. Dent. Sci. Rev. 2017, 53, 34.
V. Uskoković, RSC Adv. 2015, 5, 36614.
S. Von Euw, Y. Wang, G. Laurent, C. Drouet, F. Babonneau, N. Nassif, T. Azaïs, Sci. Rep. 2019, 9, 8456.
V. Uskoković, D. P. Uskoković, J. Biomed. Mater. Res. - Part B 2011, 96 B, 152.
H. Nygren, N. Bigdeli, L. Ilver, P. Malmberg, Biointerphases 2017, 12, 02C407.
J. Jeong, J. H. Kim, J. H. Shim, N. S. Hwang, C. Y. Heo, Biomater. Res. 2019, 23, 4.
J. Thomas, T. Gemming, in EMC 2008 14th European Microscopy Congress, Springer, Berlin Heidelberg 2009, p. 231.
L. Cui, D. A. Houston, C. Farquharson, V. E. Macrae, Bone 2016, 87, 147.
T. Kirsch, W. Wang, D. Pfander, J. Bone Miner. Res. 2003, 18, 1872.
H. B. Schiller, M. R. Hermann, J. Polleux, T. Vignaud, S. Zanivan, C. C. Friedel, Z. Sun, A. Raducanu, K. E. Gottschalk, M. Théry, M. Mann, R. Fässler, Nat. Cell Biol. 2013, 15, 625.
M. Nollet, S. Santucci-Darmanin, V. Breuil, R. Al-Sahlanee, C. Cros, M. Topi, D. Momier, M. Samson, S. Pagnotta, L. Cailleteau, S. Battaglia, D. Farlay, R. Dacquin, N. Barois, P. Jurdic, G. Boivin, D. Heymann, F. Lafont, S. S. Lu, D. W. Dempster, G. F. Carle, V. Pierrefite-Carle, Autophagy 2014, 10, 1965.
Y. P. Lo, Y. S. Liu, M. G. Rimando, J. H. C. Ho, K. H. Lin, O. K. Lee, Sci. Rep. 2016, 6, 21253.
M. Medina-Sánchez, B. Ibarlucea, N. Pérez, D. D. Karnaushenko, S. M. Weiz, L. Baraban, G. Cuniberti, O. G. Schmidt, Nano Lett. 2016, 16, 4288.

Auteurs

Raffael Herzer (R)

Institute for Integrative Nanosciences, Leibniz IFW Dresden e.V., Helmholtzstraße 20, Dresden, 01069, Germany.

Annett Gebert (A)

Institute for Complex Materials, Leibniz IFW Dresden e.V., Helmholtzstraße 20, Dresden, 01069, Germany.

Ute Hempel (U)

Institut für Physiologische Chemie, MTZ, Medizinische Fakultät der TU Dresden, Fiedlerstraße 42, Dresden, 01307, Germany.

Franziska Hebenstreit (F)

Institute for Integrative Nanosciences, Leibniz IFW Dresden e.V., Helmholtzstraße 20, Dresden, 01069, Germany.

Steffen Oswald (S)

Institute for Complex Materials, Leibniz IFW Dresden e.V., Helmholtzstraße 20, Dresden, 01069, Germany.

Christine Damm (C)

Institute for Metallic Materials, Leibniz IFW Dresden e.V., Helmholtzstraße 20, Dresden, 01069, Germany.

Oliver G Schmidt (OG)

Institute for Integrative Nanosciences, Leibniz IFW Dresden e.V., Helmholtzstraße 20, Dresden, 01069, Germany.
School of Science, TU Dresden, Dresden, 01062, Germany.
Research Center for Materials, Architectures and Integration of Nanomembranes (MAIN), TU Chemnitz, Rosenbergstraße 6, Chemnitz, 09126, Germany.

Mariana Medina-Sánchez (M)

Institute for Integrative Nanosciences, Leibniz IFW Dresden e.V., Helmholtzstraße 20, Dresden, 01069, Germany.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH