HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for "Off-the-Shelf" Immunotherapy.
B2M knockout
HLA class I
NK cells
adoptive cell transfer
allogeneic
genome editing
immunotherapy
off-the-shelf
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
07
2020
accepted:
04
12
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
16
6
2021
Statut:
epublish
Résumé
Cellular immunotherapy using chimeric antigen receptors (CARs) so far has almost exclusively used autologous peripheral blood-derived T cells as immune effector cells. However, harvesting sufficient numbers of T cells is often challenging in heavily pre-treated patients with malignancies and perturbed hematopoiesis and perturbed hematopoiesis. Also, such a CAR product will always be specific for the individual patient. In contrast, NK cell infusions can be performed in non-HLA-matched settings due to the absence of alloreactivity of these innate immune cells. Still, the infused NK cells are subject to recognition and rejection by the patient's immune system, thereby limiting their life-span
Identifiants
pubmed: 33584651
doi: 10.3389/fimmu.2020.586168
pmc: PMC7878547
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
586168Informations de copyright
Copyright © 2021 Hoerster, Uhrberg, Wiek, Horn, Hanenberg and Heinrichs.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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