In Vitro and In Vivo Anti-
Candida albicans
Galleria mellonella model
antifungal peptides
circular dichroism spectroscopy
confocal microscopy
electron microscopy
self-assembly peptides
structure-function relationship
Journal
Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827
Informations de publication
Date de publication:
10 Feb 2021
10 Feb 2021
Historique:
received:
14
01
2021
revised:
05
02
2021
accepted:
06
02
2021
entrez:
13
2
2021
pubmed:
14
2
2021
medline:
14
2
2021
Statut:
epublish
Résumé
The previously described decapeptide AKVTMTCSAS (killer peptide, KP), derived from the variable region of a recombinant yeast killer toxin-like anti-idiotypic antibody, proved to exert a variety of antimicrobial, antiviral, and immunomodulatory activities. It also showed a peculiar self-assembly ability, likely responsible for the therapeutic effect in animal models of systemic and mucosal candidiasis. The present study analyzed the biological and structural properties of peptides derived from KP by substitution or deletion of the first residue, leaving unchanged the remaining amino acids. The investigated peptides proved to exert differential in vitro and/or in vivo anti-
Identifiants
pubmed: 33578728
pii: jof7020129
doi: 10.3390/jof7020129
pmc: PMC7916522
pii:
doi:
Types de publication
Journal Article
Langues
eng
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