Midazolam and hydroxymidazolam plasma concentrations can be monitored with selected biochemical and physiological parameters of palliative care patients.
Adult
Aged
Aged, 80 and over
Bilirubin
/ blood
Biomarkers
/ blood
Body Mass Index
Creatinine
/ blood
Drug Dosage Calculations
Drug Monitoring
Female
Glomerular Filtration Rate
Humans
Hypnotics and Sedatives
/ blood
Male
Midazolam
/ analogs & derivatives
Middle Aged
Models, Biological
Palliative Care
Pilot Projects
Reproducibility of Results
GFR
LOO
MDRD
Midazolam
Palliative
Renal impairment
Validation
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
12
10
2020
revised:
15
01
2021
accepted:
18
01
2021
pubmed:
8
2
2021
medline:
20
7
2021
entrez:
7
2
2021
Statut:
ppublish
Résumé
Midazolam is one of top three drugs used in palliative care. Its use increases in the last days of hospice patients' lives while safe dosage can be challenging. Equations currently used to estimate glomerular filtration rate, e.g: the Cockroft-Gault (eGFR The pilot study included 11 Caucasians, aged 42-95, with advanced cancer disease, receiving midazolam in a hospice in-patient unit. We tested correlations among M We found ten statistically significant (p < 0.05) correlations related to midazolam pharmacokinetics and physiological factors. We formulated two equations with high degree of predictive ability, based on the eGFR The significance of correlations corresponding to the arithmetic expressions confirms that Bil, BMI, Ln(Cr) analyzed simultaneously report a series of processes on which midazolam metabolism depends. Two of ten correlations proposed came close to meet all LOO validation criteria. Current findings can help optimize midazolam treatment in palliative therapy.
Identifiants
pubmed: 33550045
pii: S0753-3322(21)00089-5
doi: 10.1016/j.biopha.2021.111304
pii:
doi:
Substances chimiques
Biomarkers
0
Hypnotics and Sedatives
0
Creatinine
AYI8EX34EU
1-hydroxymethylmidazolam
E5142BN92Z
Midazolam
R60L0SM5BC
Bilirubin
RFM9X3LJ49
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
111304Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.