Clinical Progress in Proton Radiotherapy: Biological Unknowns.
proton radiation
radiobiology
radiotherapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Feb 2021
03 Feb 2021
Historique:
received:
17
12
2020
revised:
27
01
2021
accepted:
01
02
2021
entrez:
6
2
2021
pubmed:
7
2
2021
medline:
7
2
2021
Statut:
epublish
Résumé
Clinical use of proton radiation has massively increased over the past years. The main reason for this is the beneficial depth-dose distribution of protons that allows to reduce toxicity to normal tissues surrounding the tumor. Despite the experience in the clinical use of protons, the radiobiology after proton irradiation compared to photon irradiation remains to be completely elucidated. Proton radiation may lead to differential damages and activation of biological processes. Here, we will review the current knowledge of proton radiobiology in terms of induction of reactive oxygen species, hypoxia, DNA damage response, as well as cell death after proton irradiation and radioresistance.
Identifiants
pubmed: 33546432
pii: cancers13040604
doi: 10.3390/cancers13040604
pmc: PMC7913745
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : KU Leuven
ID : C24/17/703
Organisme : Kom op tegen Kanker
ID : NA
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