Mediastinal lymphadenopathy may predict 30-day mortality in patients with COVID-19.
COVID-19
Mediastinal lymphadenopathy
Mortality
Radiological findings
Journal
Clinical imaging
ISSN: 1873-4499
Titre abrégé: Clin Imaging
Pays: United States
ID NLM: 8911831
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
04
10
2020
revised:
27
12
2020
accepted:
27
01
2021
pubmed:
6
2
2021
medline:
2
6
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
There is scarce data on the impact of the presence of mediastinal lymphadenopathy on the prognosis of coronavirus-disease 2019 (COVID-19). We aimed to investigate whether its presence is associated with increased risk for 30-day mortality in a large group of patients with COVID-19. In this retrospective cross-sectional study, 650 adult laboratory-confirmed hospitalized COVID-19 patients were included. Patients with comorbidities that may cause enlarged mediastinal lymphadenopathy were excluded. Demographics, clinical characteristics, vital and laboratory findings, and outcome were obtained from electronic medical records. Computed tomography scans were evaluated by two blinded radiologists. Univariate and multivariate logistic regression analyses were performed to determine independent predictive factors of 30-day mortality. Patients with enlarged mediastinal lymphadenopathy (n = 60, 9.2%) were older and more likely to have at least one comorbidity than patients without enlarged mediastinal lymphadenopathy (p = 0.03, p = 0.003). There were more deaths in patients with enlarged mediastinal lymphadenopathy than in those without (11/60 vs 45/590, p = 0.01). Older age (OR:3.74, 95% CI: 2.06-6.79; p < 0.001), presence of consolidation pattern (OR:1.93, 95% CI: 1.09-3.40; p = 0.02) and enlarged mediastinal lymphadenopathy (OR:2.38, 95% CI:1.13-4.98; p = 0.02) were independently associated with 30-day mortality. In this large group of hospitalized patients with COVID-19, we found that in addition to older age and consolidation pattern on CT scan, enlarged mediastinal lymphadenopathy were independently associated with increased mortality. Mediastinal evaluation should be performed in all patients with COVID-19.
Identifiants
pubmed: 33545439
pii: S0899-7071(21)00043-7
doi: 10.1016/j.clinimag.2021.01.028
pmc: PMC8064813
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-124Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
Arch Bronconeumol (Engl Ed). 2020 Nov;56(11):756-758
pubmed: 33994638
Am J Respir Cell Mol Biol. 2017 Sep;57(3):272-279
pubmed: 28443685
Invest Radiol. 2020 Jun;55(6):327-331
pubmed: 32118615
Sci Rep. 2020 Jul 9;10(1):11336
pubmed: 32647307
Eur Radiol. 2020 Sep;30(9):4930-4942
pubmed: 32346790
Theranostics. 2020 Apr 27;10(12):5613-5622
pubmed: 32373235
Radiology. 2008 Mar;246(3):697-722
pubmed: 18195376
Invest Radiol. 2020 Jun;55(6):332-339
pubmed: 32134800
EClinicalMedicine. 2020 Jul 03;24:100426
pubmed: 32766541
Eur J Radiol. 2020 Oct;131:109256
pubmed: 32919265
Respir Res. 2020 Jun 11;21(1):146
pubmed: 32527255
Am J Respir Crit Care Med. 2019 Mar 15;199(6):747-759
pubmed: 30216085
Clin Chim Acta. 2020 Oct;509:91-94
pubmed: 32511972
PLoS One. 2018 Jul 25;13(7):e0201154
pubmed: 30044866
J Infect. 2020 Aug;81(2):e16-e25
pubmed: 32335169
Clin Microbiol Infect. 2020 Oct;26(10):1417.e5-1417.e8
pubmed: 32717417
J Med Virol. 2020 Jul;92(7):891-902
pubmed: 32314805
Int J Infect Dis. 2020 Sep;98:84-89
pubmed: 32553714
J Infect. 2020 Apr;80(4):388-393
pubmed: 32112884
Radiology. 2020 Aug;296(2):E46-E54
pubmed: 32155105
J Med Virol. 2020 Jul;92(7):856-862
pubmed: 32281668
Radiol Cardiothorac Imaging. 2020 Mar 25;2(2):e200152
pubmed: 33778571
Eur Radiol. 2020 Nov;30(11):6186-6193
pubmed: 32524220
Lancet Infect Dis. 2020 Nov;20(11):1230-1231
pubmed: 32569623
J Thorac Oncol. 2009 May;4(5):568-77
pubmed: 19357537
Lancet Infect Dis. 2020 Nov;20(11):1230
pubmed: 32330440
Radiology. 2020 Jun;295(3):200463
pubmed: 32077789
Eur Radiol. 2020 Dec;30(12):6808-6817
pubmed: 32623505
Thorax. 2011 Mar;66(3):226-31
pubmed: 20880868
Radiology. 2020 Aug;296(2):E86-E96
pubmed: 32301647
Int J Infect Dis. 2020 Jul;96:467-474
pubmed: 32425643
Eur J Radiol. 2020 Sep;130:109202
pubmed: 32745895
J Clin Invest. 2014 Mar;124(3):936-42
pubmed: 24590279