Influence of the human immunodeficiency virus on cervical precancerous lesions.
CD4 count
cervical precancerous lesions
high-grade lesions
human immunodeficiency virus
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
26
01
2021
received:
22
09
2020
accepted:
03
02
2021
pubmed:
6
2
2021
medline:
20
8
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
To study the influence of HIV status on the occurrence of cervical precancerous lesions (CPL). This analytical cross-sectional study was carried out between December 1, 2019 and May 31, 2020. All women with documented HIV status screened for CPL with biopsies performed were recruited. The main variables recorded included maternal age, educational level, number of sexual partners, age at first sexual intercourse, smoking, alcohol consumption, HIV status, CD4 count, and cervical biopsy result. Fisher exact test and Student's t test were used for comparison. A p value <0.05 was considered statistically significant. Concerning women attending our screening units, CPL was more frequent among those living with HIV/AIDS (20/92; 21.7%) than among those not living with HIV/AIDS (29/290; 10.0%) (p = 0.004). As regards women living with HIV/AIDS, those with a CD4 count below 350/mL were more at risk of having a CPL (odds ratio [OR] 21.39, 95% confidence interval [CI] 5.60-81.56, p ˂ 0.001). High-grade lesions (cervical intraepithelial neoplasia Stage 2 or 3) were more often found in women living with HIV/AIDS (OR 3.83, 95% CI 1.09-13.45, p = 0.033). More attention should be paid to women living with HIV/AIDS, especially those with CD4 count less than 350/mL, who should be screened more often with biopsy frequently conducted if indicated.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
540-543Informations de copyright
© 2021 International Federation of Gynecology and Obstetrics.
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