Systematic review and meta-analysis of residential radon and lung cancer in never-smokers.
Journal
European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391
Informations de publication
Date de publication:
31 Mar 2021
31 Mar 2021
Historique:
received:
16
07
2020
accepted:
28
10
2020
entrez:
4
2
2021
pubmed:
5
2
2021
medline:
25
11
2021
Statut:
epublish
Résumé
Globally, radon is the leading risk factor for lung cancer in never-smokers (LCINS). In this study, we systematically reviewed and meta-analysed the evidence of the risk of LCINS associated with residential radon exposure. Medline and Embase databases were searched using predefined inclusion and exclusion criteria to identify relevant studies published from 1 January 1990 to 5 March 2020 focused on never-smokers. We identified four pooled collaborative studies (incorporating data from 24 case-control studies), one case-control study and one cohort study for systematic review. Meta-analysis was performed on the results of the four pooled studies due to different measures of effect and outcome reported in the cohort study and insufficient information reported for the case-control study. In a Risk estimates of lung cancer from residential radon exposure were pooled in the meta-analysis for 2341 never-smoker cases, 8967 never-smoker controls, 9937 ever-smoker cases and 12 463 ever-smoker controls. Adjusted excess relative risks (aERRs) per 100 Bq·m This study provided quantified risk estimates for lung cancer from residential radon exposure among both never-smokers and ever-smokers. Among never-smokers in radon-prone areas, men were at higher risk of lung cancer than women.
Sections du résumé
BACKGROUND
BACKGROUND
Globally, radon is the leading risk factor for lung cancer in never-smokers (LCINS). In this study, we systematically reviewed and meta-analysed the evidence of the risk of LCINS associated with residential radon exposure.
METHODS
METHODS
Medline and Embase databases were searched using predefined inclusion and exclusion criteria to identify relevant studies published from 1 January 1990 to 5 March 2020 focused on never-smokers. We identified four pooled collaborative studies (incorporating data from 24 case-control studies), one case-control study and one cohort study for systematic review. Meta-analysis was performed on the results of the four pooled studies due to different measures of effect and outcome reported in the cohort study and insufficient information reported for the case-control study. In a
RESULTS
RESULTS
Risk estimates of lung cancer from residential radon exposure were pooled in the meta-analysis for 2341 never-smoker cases, 8967 never-smoker controls, 9937 ever-smoker cases and 12 463 ever-smoker controls. Adjusted excess relative risks (aERRs) per 100 Bq·m
CONCLUSION
CONCLUSIONS
This study provided quantified risk estimates for lung cancer from residential radon exposure among both never-smokers and ever-smokers. Among never-smokers in radon-prone areas, men were at higher risk of lung cancer than women.
Identifiants
pubmed: 33536262
pii: 30/159/200230
doi: 10.1183/16000617.0230-2020
pmc: PMC9488946
pii:
doi:
Substances chimiques
Radon
Q74S4N8N1G
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright ©ERS 2021.
Déclaration de conflit d'intérêts
Conflict of interest: E.S. Cheng has no conflicts of interest to declare. Conflict of interest: S. Egger has nothing to disclose. Conflict of interest: S. Hughes has nothing to disclose. Conflict of interest: M. Weber reports other support from Cancer Australia and Australian Department of Health, outside the submitted work. Conflict of interest: J. Steinberg has nothing to disclose. Conflict of interest: B. Rahman has nothing to disclose. Conflict of interest: H. Worth has nothing to disclose. Conflict of interest: A. Ruano-Ravina has nothing to disclose. Conflict of interest: P. Rawstorne has nothing to disclose. Conflict of interest: X.Q. Yu has nothing to disclose.
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