Normal Routine Spirometry Can Mask COPD/Emphysema in Symptomatic Smokers.

COPD FEF75% emphysema small airways obstruction spirometry

Journal

Chronic obstructive pulmonary diseases (Miami, Fla.)
ISSN: 2372-952X
Titre abrégé: Chronic Obstr Pulm Dis
Pays: United States
ID NLM: 101635411

Informations de publication

Date de publication:
Jan 2021
Historique:
entrez: 29 1 2021
pubmed: 30 1 2021
medline: 30 1 2021
Statut: ppublish

Résumé

Recent studies have emphasized the difficulty of early detection of chronic obstructive pulmonary disease (COPD) in symptomatic smokers with normal routine spirometry. This includes post-bronchodilator normal forced expiratory volume in 1 second (FEV Expiratory airflow at high and low lung volumes post-bronchodilator were measured and correlated with lung computed tomography (CT) and lung pathology (6 patients) in 16 symptomatic, treated smokers, and all with normal routine spirometry. Despite normal routine spirometry, all16 patients had isolated, abnormal forced expiratory flow at 75% of FVC (FEF This study confirms our earlier observations that detection of small airways obstruction and/or emphysema, in symptomatic smokers with normal routine spirometry, requires analysis of expiratory airflow at low lung volumes, including FEF

Sections du résumé

BACKGROUND BACKGROUND
Recent studies have emphasized the difficulty of early detection of chronic obstructive pulmonary disease (COPD) in symptomatic smokers with normal routine spirometry. This includes post-bronchodilator normal forced expiratory volume in 1 second (FEV
METHODS METHODS
Expiratory airflow at high and low lung volumes post-bronchodilator were measured and correlated with lung computed tomography (CT) and lung pathology (6 patients) in 16 symptomatic, treated smokers, and all with normal routine spirometry.
RESULTS RESULTS
Despite normal routine spirometry, all16 patients had isolated, abnormal forced expiratory flow at 75% of FVC (FEF
CONCLUSION CONCLUSIONS
This study confirms our earlier observations that detection of small airways obstruction and/or emphysema, in symptomatic smokers with normal routine spirometry, requires analysis of expiratory airflow at low lung volumes, including FEF

Identifiants

DOI: 10.15326/jcopdf.2020.0176 PMID: 33513660 PMC: PMC8047618
pubmed: 33513660
doi: 10.15326/jcopdf.2020.0176
pmc: PMC8047618
doi:

Types de publication

Journal Article

Langues

eng

Informations de copyright

JCOPDF © 2021.

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Auteurs

Arthur F Gelb (AF)

Pulmonary Division, Department of Medicine, Lakewood Regional Medical Center, Lakewood, California, United States and David Geffen School of Medicine at University of California-Los Angeles Health Sciences, Los Angeles, California, United States.

Alfred Yamamoto (A)

Department of Pathology, Lakewood Regional Medical Center, Lakewood, California, United States.

Eric K Verbeken (EK)

Department of Pathology, Katholieke Univeritair Ziekenhuis Gasthuisberg, Leuven, Belgium.

James C Hogg (JC)

University of British Columbia James Hogg Research Centre, St. Paul`s Hospital Vancouver, British Columbia, Canada.

Donald P Tashkin (DP)

Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California-Los Angeles Health Sciences, Los Angeles, California, United States.

Diem N T Tran (DNT)

Independent pulmonary function investigator, Lakewood, California, United States.

Roxanna M Moridzadeh (RM)

Independent pulmonary function investigator, Lakewood, California, United States.

Christine Fraser (C)

Independent pulmonary function investigator, Lakewood, California, United States.

Mark J Schein (MJ)

Department of Radiology, Lakewood Regional Medical Center, Lakewood, California, United States.

Marc Decramer (M)

Department of Clinical and Experimental Medicine, Katholieke Univeritair Leuven-University of Leuven and University Hospitals Leuven, Leuven, Belgium.

Eric F Glassy (EF)

Affiliated Pathologists Medical Group, Rancho Dominguez, California, United States.

Jay A Nadel (JA)

Cardiovascular Research Institute and Departments of Medicine, Physiology, and Radiology, School of Medicine, University of California San Francisco, San Francisco, California, United States.

Classifications MeSH