Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration.
Insulin sensitivity
Mathematical model
Oral glucose tolerance test
Pediatrics
Protocol dependence
Journal
Metabolism open
ISSN: 2589-9368
Titre abrégé: Metabol Open
Pays: England
ID NLM: 101767753
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
30
10
2020
revised:
01
01
2021
accepted:
02
01
2021
entrez:
29
1
2021
pubmed:
30
1
2021
medline:
30
1
2021
Statut:
epublish
Résumé
The Oral Minimal Model (OMM), a differential-equations based mathematical model of glucose-insulin dynamics, utilizes data from a frequently sampled oral glucose tolerance test (OGTT) to quantify insulin sensitivity ( A 6-h frequently sampled OGTT was performed in adolescent females with obesity. Two, 3-, and 4- hour implementations of OMM assuming an exponentially-decaying rate of glucose appearance beyond measured glucose concentrations were compared to the 6-h implementation. A 4- hour OMM implementation with truncated data (4h Tr) was also considered. Data from 68 participants were included (age 15.8 ± 1.2 years, BMI 35.4 ± 5.6 kg/m These results suggest that OGTT protocol duration should be considered when implementing OMM to estimate
Identifiants
pubmed: 33511337
doi: 10.1016/j.metop.2021.100078
pii: S2589-9368(21)00002-5
pmc: PMC7817496
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100078Subventions
Organisme : NHLBI NIH HHS
ID : K24 HL145076
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK116073
Pays : United States
Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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