Live attenuated Bordetella pertussis vaccine candidate BPZE1 transiently protects against lethal pneumococcal disease in mice.
BPZE1
Bordetella pertussis
Heterologous protection
Invasive pneumococcal disease
Live vaccine
Streptococcus pneumonia
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
08 03 2022
08 03 2022
Historique:
received:
09
10
2020
revised:
03
12
2020
accepted:
08
01
2021
pubmed:
30
1
2021
medline:
11
3
2022
entrez:
29
1
2021
Statut:
ppublish
Résumé
BPZE1 is a live attenuated vaccine against infection by Bordetella pertussis, the causative agent of whooping cough. It was previously shown that BPZE1 provides heterologous protection in mouse models of disease caused by unrelated pathogens, such as influenza virus and respiratory syncytial virus. Protection was also observed in mouse models of asthma and contact dermatitis. In this study, we demonstrate that BPZE1 also displays protection against an unrelated bacterial pathogen in a mouse model of invasive pneumococcal disease mediated by Streptococcus pneumoniae. While a single administration of BPZE1 provided no protection, two doses of 10
Identifiants
pubmed: 33509692
pii: S0264-410X(21)00041-4
doi: 10.1016/j.vaccine.2021.01.025
pii:
doi:
Substances chimiques
Pertussis Vaccine
0
Vaccines, Attenuated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1555-1562Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.