Second-to-Fourth Digit Ratio (2D:4D) in Psychiatric Disorders: A Systematic Review of Case-control Studies.

Attention deficit disorder with hyperactivity Autism spectrum disorder Mental disorders Meta-analysis Substance addiction Testosterone

Journal

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
ISSN: 1738-1088
Titre abrégé: Clin Psychopharmacol Neurosci
Pays: Korea (South)
ID NLM: 101207332

Informations de publication

Date de publication:
28 Feb 2021
Historique:
received: 07 05 2020
revised: 24 07 2020
accepted: 26 07 2020
entrez: 28 1 2021
pubmed: 29 1 2021
medline: 29 1 2021
Statut: ppublish

Résumé

The second-to-fourth digit ratio (2D:4D) is an indirect, retrospective, non-invasive measure that correlates negatively with intrauterine exposure to testosterone. The present meta-analysis aimed to evaluate if 2D:4D differs between patients with psychiatric disorders and controls. In September 2019, we searched in Web of Knowledge, PsycINFO, Embase, and CINHAL, and retrieved 619 papers. We finally included 43 case-control studies which compared the 2D:4D ratio of patients with autism spectrum disorder (ASD) (n = 16), schizophrenia (n = 8), gender non-conformity (n = 7), addictions (n = 5), attention deficit-hyperactivity disorder (ADHD) (n = 4), mood disorders (n = 2), and intellectual disability (n = 1) to non-clinical controls. Meta-analyses showed that, overall, psychiatric patients had lower 2D:4D than healthy controls (n = 43, overall sample = 9,484, mean difference = -0.0056, 95% confidence interval from -0.0093 to -0.002, I

Identifiants

pubmed: 33508786
pii: cpn.2021.19.1.26
doi: 10.9758/cpn.2021.19.1.26
pmc: PMC7851454
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

26-45

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Auteurs

Laura Fusar-Poli (L)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

Alessandro Rodolico (A)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

Serena Sturiale (S)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

Bianca Carotenuto (B)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

Antimo Natale (A)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

Davide Arillotta (D)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

Spyridon Siafis (S)

Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich, Germany.

Maria Salvina Signorelli (MS)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

Eugenio Aguglia (E)

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

Classifications MeSH