Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model.
Animals
Animals, Newborn
/ growth & development
Body Weight
Female
Fetus
/ metabolism
Food Deprivation
Gestational Age
Hyperinsulinism
/ etiology
Hypertriglyceridemia
/ etiology
Insulin Resistance
Malnutrition
/ physiopathology
Placenta
/ pathology
Pregnancy
Pregnancy Complications
/ etiology
Rabbits
fetus
food restriction
liver
metabolism
mother
offspring
rabbit model
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
22 Jan 2021
22 Jan 2021
Historique:
received:
30
12
2020
revised:
15
01
2021
accepted:
18
01
2021
entrez:
27
1
2021
pubmed:
28
1
2021
medline:
10
9
2021
Statut:
epublish
Résumé
Nutritional status during gestation can influence mother and offspring metabolism. Undernutrition in pregnancy affects women in both western and developing countries, and it is associated with a high prevalence of chronic diseases in later life. The present work was conducted in the rabbit model, as a longitudinal study, to examine the effect of food restriction during early and mid-gestation, and re-feeding ad libitum until the end of pregnancy on metabolic status and body reserves of mother and, its association with development and metabolism of fetuses and female offspring to the juvenile stage. Little changes in live body weight (LBW), compensatory feed intake, similar body reserves, and metabolism were observed in dams. Placenta biometry and efficiency were slightly affected, but fetal BW and phenotype were not modified. However, hyperinsulinemia, insulin resistance, and hypertriglyceridemia were demonstrated in pre-term fetuses. In the juvenile period, these changes were not evidenced, and a similar pattern of growth and serum metabolic parameters in offspring of food-restricted mothers were found, except in serum aminotransferases levels, which increased. These were associated with higher liver fibrosis. Maternal food restriction in the early and mid-pregnancy followed by re-feeding in our rabbit model established a compensatory energy status in dams and alleviated potential long-term consequences in growth and metabolism in the offspring, even if fetal metabolism was altered.
Identifiants
pubmed: 33499108
pii: nu13020310
doi: 10.3390/nu13020310
pmc: PMC7912334
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : AGL2015-65572-C2-1-R and RTI2018-094404-B-C22
Organisme : RESEARCH GROUPS
ID : Group 920249
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