DNA Damage and the Aging Epigenome.

Aging / genetics Animals DNA Damage DNA Repair Epigenesis, Genetic Epigenome Genomic Instability Humans Models, Animal Telomere Shortening

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
04 2021
Historique:
received: 14 09 2020
revised: 28 09 2020
accepted: 01 10 2020
pubmed: 27 1 2021
medline: 28 10 2021
entrez: 26 1 2021
Statut: ppublish

Résumé

In mammals, genome instability and aging are intimately linked as illustrated by the growing list of patients with progeroid and animal models with inborn DNA repair defects. Until recently, DNA damage was thought to drive aging by compromising transcription or DNA replication, thereby leading to age-related cellular malfunction and somatic mutations triggering cancer. However, recent evidence suggests that DNA lesions also elicit widespread epigenetic alterations that threaten cell homeostasis as a function of age. In this review, we discuss the functional links of persistent DNA damage with the epigenome in the context of aging and age-related diseases.

Identifiants

DOI: 10.1016/j.jid.2020.10.006 PMID: 33494932
pubmed: 33494932
pii: S0022-202X(20)32192-8
doi: 10.1016/j.jid.2020.10.006
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

961-967

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Athanasios Siametis (A)

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Greece; Department of Biology, University of Crete, Heraklion, Greece.

George Niotis (G)

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Greece; Department of Biology, University of Crete, Heraklion, Greece.

George A Garinis (GA)

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Greece; Department of Biology, University of Crete, Heraklion, Greece. Electronic address: garinis@imbb.forth.gr.

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Classifications MeSH

Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Vieillissement › DNA Damage and the Aging Epigenome.
Recherchemedicale.com › Eucaryotes › Animaux › DNA Damage and the Aging Epigenome.
Recherchemedicale.com › Phénomènes génétiques › Altération de l'ADN › DNA Damage and the Aging Epigenome.
Recherchemedicale.com › Phénomènes génétiques › Réparation de l'ADN › DNA Damage and the Aging Epigenome.
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › DNA Damage and the Aging Epigenome.
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › DNA Damage and the Aging Epigenome.
Recherchemedicale.com › Phénomènes génétiques › Instabilité du génome › DNA Damage and the Aging Epigenome.
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DNA Damage and the Aging Epigenome.
Recherchemedicale.com › Techniques d'investigation › Modèles animaux › DNA Damage and the Aging Epigenome.
Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Raccourcissement des télomères › DNA Damage and the Aging Epigenome.