Zinc transporters and their functional integration in mammalian cells.
endoplasmic reticulum stress (ER stress)
enzyme processing
protein–protein interaction
proteomics
signal transduction
transport metal
transporter
zinc
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
Historique:
received:
30
09
2020
revised:
15
01
2021
accepted:
20
01
2021
pubmed:
25
1
2021
medline:
31
7
2021
entrez:
24
1
2021
Statut:
ppublish
Résumé
Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc dynamics in cells provide crucial cellular signaling opportunities, but also challenges for intracellular zinc homeostasis with broad disease implications. Zinc transporters play a central role in regulating cellular zinc balance and subcellular zinc distributions. The discoveries of two complementary families of mammalian zinc transporters (ZnTs and ZIPs) in the mid-1990s spurred much speculation on their metal selectivity and cellular functions. After two decades of research, we have arrived at a biochemical description of zinc transport. However, in vitro functions are fundamentally different from those in living cells, where mammalian zinc transporters are directed to specific subcellular locations, engaged in dedicated macromolecular machineries, and connected with diverse cellular processes. Hence, the molecular functions of individual zinc transporters are reshaped and deeply integrated in cells to promote the utilization of zinc chemistry to perform enzymatic reactions, tune cellular responsiveness to pathophysiologic signals, and safeguard cellular homeostasis. At present, the underlying mechanisms driving the functional integration of mammalian zinc transporters are largely unknown. This knowledge gap has motivated a shift of the research focus from in vitro studies of purified zinc transporters to in cell studies of mammalian zinc transporters in the context of their subcellular locations and protein interactions. In this review, we will outline how knowledge of zinc transporters has been accumulated from in-test-tube to in-cell studies, highlighting new insights and paradigm shifts in our understanding of the molecular and cellular basis of mammalian zinc transporter functions.
Identifiants
pubmed: 33485965
pii: S0021-9258(21)00090-9
doi: 10.1016/j.jbc.2021.100320
pmc: PMC7949119
pii:
doi:
Substances chimiques
Cation Transport Proteins
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100320Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK125746
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK123435
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.
Références
Genes (Basel). 2015 Mar 12;6(1):87-123
pubmed: 25774817
J Biol Chem. 2016 Dec 30;291(53):26950-26957
pubmed: 27875315
Nat Commun. 2018 Oct 9;9(1):4171
pubmed: 30301978
Science. 1991 Dec 20;254(5039):1776-9
pubmed: 1763327
Biochim Biophys Acta. 2003 Apr 1;1611(1-2):16-30
pubmed: 12659941
Cell Rep. 2020 Apr 28;31(4):107582
pubmed: 32348750
Nat Commun. 2016 Jun 20;7:11979
pubmed: 27321477
Gastroenterology. 2020 Feb;158(3):679-692.e1
pubmed: 31711924
Biosci Rep. 2020 Aug 28;40(8):
pubmed: 32744318
Mol Pharmacol. 2018 Sep;94(3):1092-1100
pubmed: 29980658
Biometals. 2005 Aug;18(4):295-303
pubmed: 16158220
Biochem Biophys Res Commun. 2002 Jul 5;295(1):102-6
pubmed: 12083774
Science. 1921 Jul 22;54(1386):59-67
pubmed: 17843674
Sci Signal. 2012 Feb 07;5(210):ra11
pubmed: 22317921
Nature. 2014 Aug 7;512(7512):101-4
pubmed: 25043033
Cell Mol Life Sci. 2014 Sep;71(17):3281-95
pubmed: 24710731
J Biol Chem. 2004 Jun 25;279(26):27807-15
pubmed: 15096503
J Biol Chem. 2012 Mar 16;287(12):9322-6
pubmed: 22275360
Chem Biol. 2002 Jun;9(6):673-7
pubmed: 12079778
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91
pubmed: 25074919
Annu Rev Biophys Biomol Struct. 2006;35:251-76
pubmed: 16689636
Mol Biol Cell. 2008 Apr;19(4):1295-303
pubmed: 18199682
Proc Natl Acad Sci U S A. 2012 May 8;109(19):7202-7
pubmed: 22529353
Diabetologia. 2010 Aug;53(8):1656-68
pubmed: 20424817
J Cell Sci. 1975 Jan;17(1):57-78
pubmed: 803510
ACS Chem Biol. 2014 Sep 19;9(9):2111-20
pubmed: 25011072
Am J Physiol Cell Physiol. 2011 Oct;301(4):C862-71
pubmed: 21653899
Biochemistry. 2018 Jul 3;57(26):3976-3986
pubmed: 29791142
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4237-42
pubmed: 19240214
Nature. 2019 Jun;570(7759):71-76
pubmed: 31118516
Endocrinology. 2008 Oct;149(10):4912-20
pubmed: 18583420
J Inorg Biochem. 2012 Jun;111:110-6
pubmed: 22196021
Biochem Biophys Res Commun. 2019 Jul 23;515(2):325-331
pubmed: 31151823
Gastroenterology. 2016 Oct;151(4):724-32
pubmed: 27492617
Nat Genet. 2014 Apr;46(4):357-63
pubmed: 24584071
Cell. 2010 Mar 19;140(6):900-17
pubmed: 20303879
Met Ions Life Sci. 2018 Feb 5;18:
pubmed: 29394036
Nat Rev Genet. 2005 Jun;6(6):451-64
pubmed: 15883588
J Biol Chem. 2004 Dec 3;279(49):51433-41
pubmed: 15322118
Cell Mol Life Sci. 2004 Jan;61(1):49-68
pubmed: 14704853
Am J Hum Genet. 2008 Jun;82(6):1290-305
pubmed: 18513683
Diabetes. 2017 May;66(5):1346-1358
pubmed: 28232492
J Biol Chem. 2011 Nov 18;286(46):40255-65
pubmed: 21917916
J Proteome Res. 2006 Jan;5(1):196-201
pubmed: 16396512
Cell Mol Life Sci. 2011 Jan;68(1):85-95
pubmed: 20812023
J Mol Neurosci. 2012 Jan;46(1):122-37
pubmed: 21603979
Mol Pharmacol. 2008 May;73(5):1413-23
pubmed: 18270315
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1892-6
pubmed: 6961
Nat Genet. 2002 Jul;31(3):239-40
pubmed: 12068297
EMBO J. 1995 Feb 15;14(4):639-49
pubmed: 7882967
Metallomics. 2019 Sep 1;11(9):1579-1592
pubmed: 31483418
Science. 2003 May 9;300(5621):931-6
pubmed: 12738850
J Cell Biol. 2017 Feb;216(2):317-330
pubmed: 28043970
PLoS One. 2013 Sep 06;8(9):e72446
pubmed: 24039764
Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14872-7
pubmed: 19706465
Cancer Biol Med. 2019 Aug;16(3):595-605
pubmed: 31565488
Nat Methods. 2009 Oct;6(10):737-40
pubmed: 19718032
PLoS Genet. 2018 Mar 12;14(3):e1007262
pubmed: 29529046
Biochem Biophys Res Commun. 2007 Nov 9;363(1):82-8
pubmed: 17825787
J Biol Chem. 2019 Nov 8;294(45):16992-17006
pubmed: 31591269
Science. 2007 Jun 1;316(5829):1341-5
pubmed: 17463248
J Biol Chem. 2007 Mar 9;282(10):6992-7000
pubmed: 17202136
PLoS Genet. 2016 Oct 13;12(10):e1006349
pubmed: 27736879
J Gen Physiol. 2011 May;137(5):415-26
pubmed: 21518830
PLoS One. 2010 Oct 04;5(10):
pubmed: 20957146
Cold Spring Harb Perspect Biol. 2013 Nov 01;5(11):a016790
pubmed: 24186068
Biochim Biophys Acta. 2006 Jul;1763(7):711-22
pubmed: 16675045
J Mol Biol. 2001 Dec 14;314(5):1209-25
pubmed: 11743735
Nature. 2004 Jan 8;427(6970):117-20
pubmed: 14712267
J Biol Chem. 2019 Oct 25;294(43):15686-15697
pubmed: 31471319
Cell Mol Gastroenterol Hepatol. 2016 Jan 08;2(3):369-383
pubmed: 28174721
J Biol Chem. 2005 Mar 11;280(10):8793-9
pubmed: 15613469
Am J Hum Genet. 2015 Dec 3;97(6):886-93
pubmed: 26637978
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9175-80
pubmed: 24927598
Int J Mol Sci. 2017 Oct 19;18(10):
pubmed: 29048339
J Biol Chem. 2015 Jul 17;290(29):17796-17805
pubmed: 25971965
Nature. 2010 Jun 3;465(7298):645-8
pubmed: 20463663
Biochemistry. 2012 Feb 7;51(5):963-73
pubmed: 22242765
Int J Mol Sci. 2018 Feb 01;19(2):
pubmed: 29389900
Expert Opin Ther Targets. 2016;20(3):255-67
pubmed: 26458049
Chem Rev. 2009 Oct;109(10):4682-707
pubmed: 19728700
J Biol Chem. 2016 Jul 8;291(28):14773-87
pubmed: 27226609
J Biol Chem. 2012 Aug 24;287(35):29348-61
pubmed: 22733820
J Membr Biol. 1997 Mar 15;156(2):99-103
pubmed: 9075641
BMC Microbiol. 2010 Dec 14;10:319
pubmed: 21156049
Biochemistry. 1990 Jun 19;29(24):5647-59
pubmed: 2200508
J Biol Chem. 2017 Dec 29;292(52):21598-21613
pubmed: 29114036
FASEB J. 2020 Jan;34(1):237-247
pubmed: 31914589
Nat Immunol. 2019 Mar;20(3):350-361
pubmed: 30718914
Am J Hum Genet. 2012 Mar 9;90(3):467-77
pubmed: 22341971
Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2264-76
pubmed: 20864672
J Biol Chem. 2012 Oct 5;287(41):34032-43
pubmed: 22898811
Oncogene. 2003 Sep 4;22(38):6005-12
pubmed: 12955079
J Cell Biol. 2007 May 21;177(4):637-45
pubmed: 17502426
J Neurosci. 2010 Feb 3;30(5):1631-6
pubmed: 20130173
J Cell Physiol. 2015 Oct;230(10):2345-50
pubmed: 25808614
Cancer Sci. 2007 May;98(5):692-7
pubmed: 17359283
Biochemistry. 1997 Mar 4;36(9):2669-78
pubmed: 9054574
Exp Diabetes Res. 2012;2012:190309
pubmed: 22536213
J Neurosci Res. 2015 Feb;93(2):370-9
pubmed: 25284286
J Biol Chem. 2004 Mar 19;279(12):11106-11
pubmed: 14715648
Nat Commun. 2016 May 27;7:11601
pubmed: 27231142
Science. 2004 Apr 2;304(5667):87-90
pubmed: 15066776
Biophys J. 1993 Feb;64(2):525-32
pubmed: 8457676
J Biol Chem. 2004 Mar 26;279(13):12043-50
pubmed: 14715669
Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3042-3047
pubmed: 29507252
Cell Death Differ. 2019 Jun;26(6):1138-1155
pubmed: 30237509
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5
pubmed: 25074913
J Am Chem Soc. 2007 Feb 7;129(5):1378-85
pubmed: 17263422
Traffic. 2018 Nov;19(11):813-822
pubmed: 29952128
Mol Cell Endocrinol. 2015 Oct 15;414:53-63
pubmed: 26213325
J Biol Chem. 2019 Sep 6;294(36):13327-13335
pubmed: 31320477
J Biol Chem. 2004 Sep 17;279(38):39251-9
pubmed: 15258151
J Biol Chem. 2017 Feb 10;292(6):2159-2173
pubmed: 28028180
Nat Struct Biol. 2000 Sep;7(9):766-71
pubmed: 10966647
J Biol Chem. 2010 Dec 10;285(50):39013-20
pubmed: 20876577
Commun Biol. 2018 Aug 22;1:113
pubmed: 30271993
Biochem J. 2016 Sep 1;473(17):2611-21
pubmed: 27303047
J Biol Chem. 2014 Aug 22;289(34):23653-61
pubmed: 25016022
PLoS One. 2009 Jun 12;4(6):e5896
pubmed: 19521526
Mol Cell Biol. 2009 Jan;29(1):129-39
pubmed: 18936158
J Biol Chem. 2009 Nov 20;284(47):32434-43
pubmed: 19767393
J Bacteriol. 2001 Aug;183(15):4664-7
pubmed: 11443104
IUBMB Life. 2010 Mar;62(3):176-82
pubmed: 20120011
Biochem J. 2016 Aug 15;473(16):2531-44
pubmed: 27274087
Diabetes. 2009 Sep;58(9):2070-83
pubmed: 19542200
Biochem J. 2019 Jun 28;476(12):1791-1803
pubmed: 31164399
Biochem J. 2009 Jul 15;421(3):371-6
pubmed: 19450229
J Biol Chem. 2020 Apr 24;295(17):5669-5684
pubmed: 32179649
Proc Natl Acad Sci U S A. 1988 Jun;85(11):3865-9
pubmed: 3287379
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18636-41
pubmed: 18003899
Nat Rev Mol Cell Biol. 2008 Dec;9(12):944-57
pubmed: 19002207
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5805-E5814
pubmed: 28673968
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2238-43
pubmed: 11226223
J Biol Chem. 2017 Mar 10;292(10):4034-4043
pubmed: 28130446
J Biol Chem. 2018 Jan 12;293(2):579-587
pubmed: 29184000
Inorg Chem. 2013 Oct 7;52(19):10983-91
pubmed: 24059258
J Biol Chem. 2011 May 6;286(18):16363-73
pubmed: 21402707
J Biol Chem. 2014 Mar 14;289(11):7275-92
pubmed: 24451381
J Biol Chem. 2003 Aug 29;278(35):33474-81
pubmed: 12801924
Mol Med. 2007 Jul-Aug;13(7-8):396-406
pubmed: 17673939
J Biol Chem. 2011 Jul 22;286(29):25778-89
pubmed: 21613223
J Biol Chem. 2015 Apr 3;290(14):9050-63
pubmed: 25657003
J Biol Chem. 2009 Nov 6;284(45):30798-806
pubmed: 19759014
Sci Rep. 2017 Nov 27;7(1):16381
pubmed: 29180655
Biochem J. 2013 Oct 15;455(2):229-37
pubmed: 23919497
Traffic. 2016 Mar;17(3):267-88
pubmed: 26728129
J Cell Biol. 2004 Aug 2;166(3):325-35
pubmed: 15277543
FEBS J. 2007 Aug;274(15):3986-97
pubmed: 17635580
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10567-72
pubmed: 20498051
Nat Commun. 2019 Feb 5;10(1):603
pubmed: 30723194
PLoS One. 2012;7(7):e40972
pubmed: 22829903
Trends Endocrinol Metab. 2014 Aug;25(8):415-24
pubmed: 24751356
J Biol Chem. 2020 May 8;295(19):6312-6329
pubmed: 32188696
Prion. 2012 Sep-Oct;6(4):317-21
pubmed: 22575750
Biol Chem. 2007 Dec;388(12):1301-12
pubmed: 18020946
J Am Chem Soc. 2008 Mar 26;130(12):3844-52
pubmed: 18303888
Curr Top Med Chem. 2007;7(4):391-403
pubmed: 17305581
FEBS J. 2015 May;282(10):1965-79
pubmed: 25732056
Diabetes. 2000 Mar;49(3):367-72
pubmed: 10868957
Metallomics. 2017 May 24;9(5):471-481
pubmed: 28205653
ACS Chem Biol. 2006 Mar 17;1(2):103-11
pubmed: 17163650
J Clin Invest. 2013 Oct;123(10):4513-24
pubmed: 24051378
Chem Rev. 2007 Aug;107(8):3514-43
pubmed: 17683160
Science. 2007 Jun 1;316(5829):1331-6
pubmed: 17463246
FEBS Lett. 1995 Nov 27;376(1-2):53-7
pubmed: 8521965
Metallomics. 2018 Dec 12;10(12):1755-1776
pubmed: 30358795
Pflugers Arch. 2004 Feb;447(5):744-51
pubmed: 12748859
J Immunol. 2000 Jun 1;164(11):5981-9
pubmed: 10820281
J Invest Dermatol. 2017 Aug;137(8):1682-1691
pubmed: 28545780
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2140-5
pubmed: 23341604
Science. 2001 Jun 29;292(5526):2488-92
pubmed: 11397910
Biochemistry. 1975 Jul 29;14(15):3439-44
pubmed: 807244
J Biol Chem. 2004 Feb 6;279(6):4523-30
pubmed: 14612438
J Neurochem. 1999 Aug;73(2):450-6
pubmed: 10428039
Endocrinology. 2009 Jun;150(6):2586-95
pubmed: 19213841
Nat Struct Mol Biol. 2009 Oct;16(10):1063-7
pubmed: 19749753
J Neurochem. 2000 Aug;75(2):594-605
pubmed: 10899934
Sci Rep. 2017 Jan 18;7:40313
pubmed: 28098160
Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C291-7
pubmed: 22621784
BMC Cancer. 2020 May 11;20(1):403
pubmed: 32393195
J Biol Chem. 2015 Jul 24;290(30):18757-69
pubmed: 25969539
Cancer Res. 1977 Jul;37(7 Pt 1):2050-6
pubmed: 861934
J Biol Chem. 2005 Apr 15;280(15):15456-63
pubmed: 15705588
J Biol Chem. 2004 Jun 4;279(23):24631-9
pubmed: 15054103
Genes Dev. 2004 Dec 15;18(24):3066-77
pubmed: 15601821
Nature. 2020 Apr;580(7803):402-408
pubmed: 32296183
Diabetes. 2016 Jun;65(6):1472-80
pubmed: 27222391
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15841-6
pubmed: 17898179
BMC Genomics. 2007 Apr 23;8:107
pubmed: 17448255
Diabetes. 2004 Sep;53(9):2330-7
pubmed: 15331542
Annu Rev Biochem. 2003;72:395-447
pubmed: 12651740
Science. 2007 Sep 21;317(5845):1746-8
pubmed: 17717154
Mol Pharmacol. 2016 Dec;90(6):726-737
pubmed: 27754899
Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12676-81
pubmed: 9356509
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9903-8
pubmed: 23716681
J Diabetes Investig. 2013 Nov 27;4(6):511-6
pubmed: 24843702
Am J Physiol Regul Integr Comp Physiol. 2016 Mar 1;310(5):R459-68
pubmed: 26702153
J Biol Chem. 2000 Aug 18;275(33):25057-60
pubmed: 10816601
J Biol Chem. 2004 Apr 23;279(17):17173-80
pubmed: 14960568
Nat Genet. 2019 Nov;51(11):1596-1606
pubmed: 31676859
Biochemistry. 2020 Jan 14;59(1):74-79
pubmed: 31718170
Nature. 2017 Feb 8;542(7640):177-185
pubmed: 28179656
Adv Nutr. 2011 Mar;2(2):101-11
pubmed: 22332039
Physiol Rev. 2015 Jul;95(3):749-84
pubmed: 26084690
Endocrinology. 2003 Mar;144(3):1032-44
pubmed: 12586780
J Proteome Res. 2014 Dec 5;13(12):5293-309
pubmed: 25337643
PLoS One. 2008;3(11):e3642
pubmed: 18985159
J Biol Chem. 2006 Dec 22;281(51):39699-707
pubmed: 17065149
Nat Rev Immunol. 2011 Feb;11(2):98-107
pubmed: 21233852
J Biol Chem. 2005 Sep 2;280(35):30956-62
pubmed: 15994300
Cell Metab. 2015 Mar 3;21(3):357-68
pubmed: 25640731
Nature. 1966 Aug 27;211(5052):969-70
pubmed: 5968307
Am J Hum Genet. 2015 Dec 3;97(6):894-903
pubmed: 26637979
Biosci Rep. 2020 Feb 28;40(2):
pubmed: 32109290
Cell. 2014 Feb 13;156(4):730-43
pubmed: 24529376
Biochem J. 2004 Jan 1;377(Pt 1):131-9
pubmed: 14525538
Nature. 2004 May 20;429(6989):298-302
pubmed: 15129296
Am J Hum Genet. 2012 Mar 9;90(3):457-66
pubmed: 22341972
Endocrinology. 2009 Jun;150(6):2577-85
pubmed: 19213833
J Physiol Sci. 2017 Mar;67(2):283-301
pubmed: 28130681
PLoS One. 2013 May 31;8(5):e64045
pubmed: 23741301
Vitam Horm. 2014;95:365-90
pubmed: 24559925
Nature. 2007 Feb 22;445(7130):881-5
pubmed: 17293876
EMBO J. 1999 Jun 1;18(11):2930-40
pubmed: 10357806
Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16876-81
pubmed: 23027977
Curr Opin Chem Biol. 2020 Apr;55:145-150
pubmed: 32114317
Pflugers Arch. 2004 Feb;447(5):796-800
pubmed: 12748861
J Cell Sci. 2006 Oct 15;119(Pt 20):4199-206
pubmed: 16984975
Proteomics. 2011 Mar;11(6):1153-9
pubmed: 21365760
J Biol Chem. 2016 Jul 29;291(31):15940-57
pubmed: 27307044
J Biol Chem. 2019 May 17;294(20):8046-8063
pubmed: 30914478
J Biol Chem. 2005 Aug 5;280(31):28811-8
pubmed: 15961382
J Biol Chem. 2005 Jan 7;280(1):637-43
pubmed: 15525635
J Biol Chem. 1992 May 15;267(14):10193-7
pubmed: 1577787
Endocr Rev. 2008 May;29(3):317-33
pubmed: 18436705
Cell Mol Life Sci. 2021 Feb;78(4):1781-1798
pubmed: 32797246
Biochemistry. 2019 Apr 2;58(13):1705-1708
pubmed: 30874431
Mol Cell. 2013 Oct 10;52(1):75-86
pubmed: 24076220
Mol Aspects Med. 2013 Apr-Jun;34(2-3):612-9
pubmed: 23506894
Annu Rev Nutr. 2011 Aug 21;31:139-53
pubmed: 21548772
Elife. 2020 Jul 29;9:
pubmed: 32723473
Biochem J. 2013 Apr 15;451(2):155-63
pubmed: 23368743
J Biol Chem. 2005 Oct 7;280(40):33716-24
pubmed: 16049012
J Biol Chem. 2009 Jun 26;284(26):17677-86
pubmed: 19366695
Cell Metab. 2016 Oct 11;24(4):593-607
pubmed: 27667667
Dalton Trans. 2007 Nov 14;(42):4751-9
pubmed: 17955125
J Biol Chem. 2006 Jun 30;281(26):17743-50
pubmed: 16636052
J Mol Biol. 2012 Sep 28;422(4):556-574
pubmed: 22687393
Nature. 2017 May 25;545(7655):505-509
pubmed: 28514442
Cell Metab. 2006 Sep;4(3):245-54
pubmed: 16950141
Arch Microbiol. 2005 Jan;183(1):9-18
pubmed: 15549269
Metallomics. 2015 Sep;7(9):1319-30
pubmed: 25882556
Biometals. 2012 Aug;25(4):643-55
pubmed: 22318508
J Exp Med. 2008 Jan 21;205(1):35-42
pubmed: 18158319
J Biol Chem. 2015 May 22;290(21):13064-78
pubmed: 25851903
Science. 1998 Apr 3;280(5360):69-77
pubmed: 9525859
Nutrients. 2019 Feb 15;11(2):
pubmed: 30781350
Am J Hum Genet. 2002 Jul;71(1):66-73
pubmed: 12032886
Sci Adv. 2017 Aug 25;3(8):e1700344
pubmed: 28875161
J Biol Chem. 2019 Feb 22;294(8):2815-2826
pubmed: 30593504
Biochim Biophys Acta. 2014 Dec;1838(12):3203-11
pubmed: 25242380
Hum Mol Genet. 2004 Mar 1;13(5):563-71
pubmed: 14709598
Structure. 2008 Sep 10;16(9):1378-88
pubmed: 18786400
FEBS Lett. 2010 Jun 18;584(12):2572-9
pubmed: 20420836
Curr Opin Struct Biol. 1998 Apr;8(2):189-94
pubmed: 9631292