A Tumor Suppressor Enhancer of
NOTCH1
PTEN
T-ALL
T-cell acute lymphoblastic leukemia
enhancer
Journal
Blood cancer discovery
ISSN: 2643-3249
Titre abrégé: Blood Cancer Discov
Pays: United States
ID NLM: 101764786
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
entrez:
18
1
2021
pubmed:
19
1
2021
medline:
19
1
2021
Statut:
ppublish
Résumé
Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the pathogenesis of various cancers, including T-cell leukemia (T-ALL). Here, we identify a highly conserved distal enhancer (PE) that interacts with the
Identifiants
pubmed: 33458694
doi: 10.1158/2643-3230.BCD-20-0201
pmc: PMC7810363
mid: NIHMS1647653
pii: 2643-3230.BCD-20-0201
doi:
Substances chimiques
Receptor, Notch1
0
PTEN Phosphohydrolase
EC 3.1.3.67
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
92-109Subventions
Organisme : NCI NIH HHS
ID : R00 CA197869
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA236936
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA072720
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA233662
Pays : United States
Organisme : NIH HHS
ID : S10 OD012346
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest disclosure: The authors declare no competing financial interests.
Références
Oncogene. 2016 Jul 28;35(30):3887-96
pubmed: 26616857
Oncogene. 2012 Sep 6;31(36):4034-44
pubmed: 22158038
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Oncogene. 2008 Sep 18;27(41):5443-53
pubmed: 18794879
Nat Rev Genet. 2011 Apr;12(4):283-93
pubmed: 21358745
Nat Immunol. 2019 Feb;20(2):163-172
pubmed: 30643263
Cancer Discov. 2020 May;10(5):724-745
pubmed: 32188707
J Clin Invest. 2010 Jul;120(7):2497-507
pubmed: 20516645
J Exp Med. 1996 May 1;183(5):2283-91
pubmed: 8642337
Science. 2004 Oct 8;306(5694):269-71
pubmed: 15472075
Nature. 2008 May 1;453(7191):110-4
pubmed: 18408710
Bioinformatics. 2016 Aug 15;32(16):2511-3
pubmed: 27153610
PLoS Biol. 2003 Dec;1(3):E59
pubmed: 14691534
Nature. 2014 Mar 27;507(7493):455-461
pubmed: 24670763
Cell. 2014 Dec 18;159(7):1665-80
pubmed: 25497547
Endocrinology. 2007 Aug;148(8):3987-97
pubmed: 17495001
Cell. 2015 Aug 13;162(4):900-10
pubmed: 26276636
Cancer Cell. 2013 Dec 9;24(6):766-76
pubmed: 24291004
Cell Syst. 2018 Feb 28;6(2):256-258.e1
pubmed: 29428417
Haematologica. 2012 Sep;97(9):1405-13
pubmed: 22491738
Epigenomics. 2016 Mar;8(3):389-99
pubmed: 26673039
Genome Biol. 2014;15(12):550
pubmed: 25516281
Nat Biotechnol. 2016 May;34(5):525-7
pubmed: 27043002
Nat Immunol. 2020 Oct;21(10):1280-1292
pubmed: 32719521
Genome Res. 2004 Apr;14(4):708-15
pubmed: 15060014
Cell Rep. 2016 Jun 28;16(1):48-55
pubmed: 27320916
Nat Genet. 2017 Aug;49(8):1211-1218
pubmed: 28671688
Nat Methods. 2019 Dec;16(12):1289-1296
pubmed: 31740819
Nature. 2008 May 22;453(7194):529-33
pubmed: 18463637
Nat Methods. 2009 Nov;6(11):837-42
pubmed: 19820713
Nature. 2006 May 25;441(7092):518-22
pubmed: 16633340
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2022-7
pubmed: 18250301
Bioinformatics. 2020 Feb 15;36(4):1150-1158
pubmed: 31501871
Nat Genet. 1998 Aug;19(4):348-55
pubmed: 9697695
Blood. 2015 Jan 29;125(5):852-5
pubmed: 25477498
Nat Med. 2017 Oct;23(10):1226-1233
pubmed: 28869610
Nat Med. 2014 Oct;20(10):1130-7
pubmed: 25194570
Cell. 2019 Feb 7;176(4):897-912.e20
pubmed: 30686579
Nat Rev Genet. 2014 Apr;15(4):272-86
pubmed: 24614317
Am J Hematol. 2019 Apr;94(4):E93-E96
pubmed: 30614545
Cell. 2016 Nov 17;167(5):1369-1384.e19
pubmed: 27863249
Nature. 2012 Sep 6;489(7414):57-74
pubmed: 22955616
Nat Genet. 2020 Apr;52(4):388-400
pubmed: 32203470
Nat Rev Cancer. 2016 Jul 25;16(8):494-507
pubmed: 27451956
Trends Cancer. 2018 Dec;4(12):810-822
pubmed: 30470303
Genome Biol. 2010;11(10):R106
pubmed: 20979621
Nat Genet. 2016 Jan;48(1):4-6
pubmed: 26711108
Nat Methods. 2013 Dec;10(12):1213-8
pubmed: 24097267
Science. 2013 Jul 26;341(6144):399-402
pubmed: 23744781
PLoS Comput Biol. 2016 Mar 03;12(3):e1004780
pubmed: 26938081
Nat Rev Cancer. 2016 Aug;16(8):483-93
pubmed: 27364481
Nature. 2014 Jun 12;510(7504):278-82
pubmed: 24759320
Mol Cancer Res. 2017 Aug;15(8):1051-1062
pubmed: 28483946
J Vis Exp. 2018 Apr 10;(134):
pubmed: 29708546
Cell Rep. 2020 Sep 29;32(13):108206
pubmed: 32997998
Cancer Cell. 2003 Sep;4(3):209-21
pubmed: 14522255
Br J Haematol. 2018 Sep;182(5):705-711
pubmed: 29938780
Nature. 2012 Apr 11;485(7398):376-80
pubmed: 22495300
Nature. 2018 Jan 25;553(7689):515-520
pubmed: 29342133
Nat Commun. 2019 Sep 20;10(1):4295
pubmed: 31541153
Nat Med. 2007 Oct;13(10):1203-10
pubmed: 17873882
Nature. 2006 May 25;441(7092):475-82
pubmed: 16598206
Cell Rep. 2015 Mar 3;10(8):1297-309
pubmed: 25732821
Genome Biol. 2011 Nov 14;12(11):R113
pubmed: 22082242
Cell. 2014 Mar 27;157(1):13-25
pubmed: 24679523
Nat Rev Mol Cell Biol. 2012 Apr 04;13(5):283-96
pubmed: 22473468
Science. 2012 Dec 7;338(6112):1360-3
pubmed: 23118011
Nature. 2015 Oct 22;526(7574):519-24
pubmed: 26200345
Nat Rev Mol Cell Biol. 2018 Sep;19(9):547-562
pubmed: 29858604
Annu Rev Biochem. 2014;83:641-69
pubmed: 24905788
Thyroid. 2019 Jun;29(6):809-823
pubmed: 30924726
Science. 2014 Dec 12;346(6215):1373-7
pubmed: 25394790
Cancer Discov. 2019 Dec;9(12):1774-1791
pubmed: 31519704
Nat Commun. 2017 Mar 23;8:14771
pubmed: 28332494
Nat Med. 2015 Oct;21(10):1182-9
pubmed: 26390244
Cell. 2016 Mar 10;164(6):1110-1121
pubmed: 26967279
Nature. 2012 Jan 11;481(7380):157-63
pubmed: 22237106